Narrative Review: Advancing Dysbiosis Treatment in Onco-Hematology with Microbiome-Based Therapeutic Approach DOI Creative Commons

Salomé Biennier,

Mathieu Fontaine,

Aurore Duquenoy

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2256 - 2256

Published: Nov. 7, 2024

This review explores the complex relationship between gut dysbiosis and hematological malignancies, focusing on graft-versus-host disease (GvHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. We discuss how alterations microbial diversity composition can influence development, progression, treatment outcomes blood cancers. The mechanisms by which microbiota impacts these conditions are examined, including modulation of immune responses, production metabolites, effects intestinal barrier function. Recent advances microbiome-based therapies for treating preventing GvHD highlighted, with emphasis full ecosystem standardized donor-derived products. Overall, this underscores growing importance microbiome research hematology–oncology its potential to complement existing treatments improve thousands patients worldwide.

Language: Английский

Impact of Metabolites from Foodborne Pathogens on Cancer DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3886 - 3886

Published: Dec. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Language: Английский

Citations

11
Narrative Review: Advancing Dysbiosis Treatment in Onco-Hematology with Microbiome-Based Therapeutic Approach DOI Creative Commons

Salomé Biennier,

Mathieu Fontaine,

Aurore Duquenoy

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2256 - 2256

Published: Nov. 7, 2024

This review explores the complex relationship between gut dysbiosis and hematological malignancies, focusing on graft-versus-host disease (GvHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. We discuss how alterations microbial diversity composition can influence development, progression, treatment outcomes blood cancers. The mechanisms by which microbiota impacts these conditions are examined, including modulation of immune responses, production metabolites, effects intestinal barrier function. Recent advances microbiome-based therapies for treating preventing GvHD highlighted, with emphasis full ecosystem standardized donor-derived products. Overall, this underscores growing importance microbiome research hematology–oncology its potential to complement existing treatments improve thousands patients worldwide.

Language: Английский

Citations

2