Analysis and applications of respiratory surface EMG: report of a round table meeting

Critical Care, Journal Year: 2024, Volume and Issue: 28(1)

Published: Jan. 2, 2024

Abstract Surface electromyography (sEMG) can be used to measure the electrical activity of respiratory muscles. The possible applications sEMG span from patients suffering acute failure receiving chronic home mechanical ventilation, evaluate muscle function, titrate ventilatory support and guide treatment. However, is mainly as a monitoring tool for research its use in clinical practice still limited—in part due lack standardization transparent reporting. During this round table meeting, recommendations on data acquisition, processing, interpretation, potential were discussed. This paper informs researcher interested about current state art sEMG, knowledge gaps future with failure.

Language: Английский

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Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease

Experimental Neurology, Journal Year: 2021, Volume and Issue: 347, P. 113891 - 113891

Published: Oct. 11, 2021

We review progress towards greater mechanistic understanding and clinical translation of a strategy to improve respiratory non-respiratory motor function in people with neuromuscular disorders, therapeutic acute intermittent hypoxia (tAIH). In 2016 2020, workshops create update "road map translation" were held help guide future research development tAIH restore movement living chronic, incomplete spinal cord injuries. After briefly discussing the pioneering, non-targeted basic inspiring this novel approach, we then summarize workshop recommendations, emphasizing critical knowledge gaps, priorities for effort, steps needed accelerate as evaluate potential routine use. Highlighted areas include: 1) understanding, particularly systems; 2) optimization protocols maximize benefits; 3) identification combinatorial treatments that amplify plasticity or remove constraints, including task-specific training; 4) biomarkers individuals most/least likely benefit from tAIH; 5) assessment long-term safety; 6) simple, safe effective device administer home settings. Finally, ongoing trials recent investigations SCI other disorders compromise function, ALS, multiple sclerosis, stroke.

Language: Английский

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Intermittent Hypoxia Conditioning: A Potential Multi-Organ Protective Therapeutic Strategy

International Journal of Medical Sciences, Journal Year: 2023, Volume and Issue: 20(12), P. 1551 - 1561

Published: Jan. 1, 2023

Severe hypoxia can induce a range of systemic disorders; however, surprising resilience be obtained through sublethal adaptation to hypoxia, process termed as hypoxic conditioning.A particular form this strategy, known intermittent conditioning hormesis, alternates exposure and normoxic conditions, facilitating reduced oxygen availability.This technique, originally employed in sports high-altitude medicine, has shown promise multiple pathologies when applied with calibrated mild moderate appropriate cycles.Recent studies have extensively investigated the protective role its underlying mechanisms using animal models, demonstrating potential organ protection.This involves processes such reduction oxidative stress, inflammation, apoptosis, along enhancement gene expression, among others.Given that fosters beneficial physiological responses across organs systems, review presents comprehensive analysis existing on advantages various organs.It aims draw attention possibility clinically applying multi-organ strategy.This comprehensively discusses effects outlines procedures for implementing provides brief overview hypoxia.

Language: Английский

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Respiratory neuroplasticity: Mechanisms and translational implications of phrenic motor plasticity

Handbook of clinical neurology, Journal Year: 2022, Volume and Issue: unknown, P. 409 - 432

Published: Jan. 1, 2022

Language: Английский

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Respiratory therapies for Amyotrophic Lateral Sclerosis: A state of the art review

Chronic Respiratory Disease, Journal Year: 2023, Volume and Issue: 20

Published: May 23, 2023

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition noteworthy for upper and lower motor neuron death. Involvement of respiratory pools leads to progressive pathology. These impairments include decreases in neural activation muscle coordination, airway obstruction, weakened defenses, restrictive lung disease, increased risk pulmonary infections, weakness atrophy muscles. neural, airway, pulmonary, neuromuscular changes deteriorate integrated respiratory-related functions including sleep, cough, swallowing, breathing. Ultimately, complications account large portion morbidity mortality ALS. This state-of-the-art review highlights applications therapies ALS, volume recruitment, mechanical insufflation-exsufflation, non-invasive ventilation, strength training. Therapeutic acute intermittent hypoxia, an emerging therapeutic tool inducing plasticity will also be introduced. A focus on evidence future work underscores the common goal continue improve survival patients living with

Language: Английский

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Randomized controlled trial of intermittent hypoxia in Parkinson’s disease: study rationale and protocol

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 22, 2024

Parkinson's disease (PD) is a neurodegenerative for which no disease-modifying therapies exist. Preclinical and clinical evidence suggest that repeated exposure to intermittent hypoxia might have short- long-term benefits in PD. In previous exploratory phase I trial, we demonstrated in-clinic safe feasible with short-term symptomatic effects on PD symptoms. The current study aims explore the safety, tolerability, feasibility, net of four-week protocol, administered at home, individuals

Language: Английский

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Response of Circulating Inflammatory Markers to Intermittent Hypoxia-Hyperoxia Training in Healthy Elderly People and Patients with Mild Cognitive Impairment

Life, Journal Year: 2022, Volume and Issue: 12(3), P. 432 - 432

Published: March 16, 2022

Intermittent hypoxia-hyperoxia training (IHHT) is a non-pharmacological therapeutic modality for management of some chronic- and age-related pathologies, such as Alzheimer’s disease (AD). Our previous studies demonstrated significant improvement cognitive function after IHHT in the patients with mild impairment (MCI). The present study further investigated effects on pro-inflammatory factors healthy elderly individuals early signs AD. Twenty-nine subjects (13 without syndrome 16 diagnosed MCI; age 52 to 76 years) were divided into four groups: Healthy+Sham (n = 7), Healthy+IHHT 6), MCI+Sham MCI+IHHT 10). was carried out 5 days per week 3 weeks (total 15 sessions), each daily session included 4 cycles 5-min hypoxia (12% FIO2) 3-min hyperoxia (33% FIO2). Decline indices observed initially both groups. sham did not alter any parameters, whereas resulted latency evoked potentials, along elevation APP110, GDF15 expression, MMP9 activity those MCI. Increased MMP2 activity, HMGB1, P-selectin expression decreased NETs formation Aβ also group. There negative correlation between MoCA score plasma (R −0.5799, p < 0.05) before initiation IHHT. enhanced associated longer event-related potentials P330 N200 0.6263, 0.05 R 0.5715, 0.05, respectively). In conclusion, upregulated circulating levels inflammatory markers, which may represent potential triggers cellular adaptive reprogramming, leading against dysfunction neuropathological changes during progression Further investigation needed clarify if there causative relationship improved elevated markers following

Language: Английский

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Amplification of the therapeutic potential of AMPA receptor potentiators from the nootropic era to today

Pharmacology Biochemistry and Behavior, Journal Year: 2025, Volume and Issue: 248, P. 173967 - 173967

Published: Jan. 31, 2025

Language: Английский

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Individualized Algorithm-Based Intermittent Hypoxia Improves Quality of Life in Patients Suffering from Long-Term Sequelae After COVID-19 Infection

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1590 - 1590

Published: Feb. 26, 2025

Background/Objectives: Post-COVID-19 condition (PCC), also known as long COVID, has emerged a recognized syndrome affecting millions of people worldwide, significantly impairing their quality life. Currently, no effective therapeutic options are available to manage this condition. The objective the present study was evaluate long-term effects personalized, algorithm-based intermittent hypoxia–hyperoxia conditioning (IHHC) on life and pain in patients with PCC. Methods: This open-label cohort included 199 PCC patients, aged 11–87 years (female-to-male ratio: 67:33) experiencing moderate-to-severe fatigue, between 1 January 2020 31 December 2023. Each patient received an treatment plan tailored demographics, symptom duration, baseline (NRS) (SF-36) scores. Patients average six sessions (range: 2–21), each consisting hypoxic–hyperoxic cycles, hypoxia (9–13% O2) lasting 3–8 min hyperoxia (34–36% 1–3 min. primary outcomes were changes NRS SF-36 scores at 6-week 6-month follow-ups. Results: At follow-up after initiation, increased by 102 points (p < 0.001, 95% CI: 78.4–127), improvement persisted (Δ106, p 57.0–154). Pain reduced 28–32% both time points, exceeding clinically relevant threshold. Health transition indicated patient-perceived health status. Conclusions: In study, IHHC alleviated improved suffering from persistent sequelae COVID-19 infection. sustained for up months. Further research is warranted elucidate mechanisms underlying IHHC’s population.

Language: Английский

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Acute adenosine receptor antagonism in combination with acute intermittent hypoxia (AIH) to promote breathing plasticity in Amyotrophic lateral sclerosis: study protocol for a randomized, double-blinded, placebo-controlled trial (Preprint)

Published: April 17, 2025

Respiratory impairment is a major concern in amyotrophic lateral sclerosis (ALS), shortening survival and lowering quality of life. One therapy with promise to delay respiratory decline ALS acute intermittent hypoxia (AIH) consisting alternating periods breathing mildly hypoxic (~9-12% O2) normoxic (21% gas. AIH stimulates spinal, serotonin-dependent neuroplasticity rodent models, conferring functional benefits diverse physiological systems without detectable pathology. However, AIH-induced constrained by distinct signaling cascades initiated spinal adenosine. We propose investigate therapeutic strategy compromise those living combining selective adenosine 2A receptor (A2A) inhibitor (istradefylline) AIH. The fundamental hypothesis guiding this proposal that single trial after pretreatment istradefylline (IST) enhances versus or sham intervention. evaluate resting breathing, strength, participant-reported symptoms, adults combined plus A mixed within between subject study design incorporates 4 test sessions, separated ~2 weeks (+/- 5 days). Testing conditions include sessions of: + IST, placebo, (i.e., normoxia) IST. Safety feasibility will be characterized using the rate adverse events, changes vital signs, sensations (Aim 1). Neuroplasticity motor function evaluated as voluntary control, maximal pinch force 2). As January 2025, 10/16 subjects 5/16 control completed procedures. Recruiting ongoing, final complete December 2025. Publication results expected end 2026. These aims provide crucial data regarding preliminary safety paired intervention, help optimize rehabilitation strategy, thereby further research concerning novel treatment for ALS. This was registered ClinicalTrials.gov database on 22 April, 2022 (registration number: NCT05377424).

Language: Английский

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