From environment to environmental adaptation: Environmental perspectives on the study of food and medicine homology

Food & medicine homology., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1852 - 1852

Published: Feb. 3, 2024

Obstructive sleep apnea (OSA), a respiratory disorder associated with cardiovascular diseases, is more prevalent in men. However, OSA occurrence pregnant women rises to level comparable men during late gestation, creating persistent effects on both maternal and offspring health. The exact mechanisms behind OSA-induced diseases remain unclear, but inflammation oxidative stress play key role. Animal models using intermittent hypoxia (IH), hallmark of OSA, reveal several pro-inflammatory signaling pathways at males, such as TLR4/MyD88/NF-κB/MAPK, miRNA/NLRP3, COX signaling, along shifts immune cell populations function. Limited evidence suggests similarities pregnancies offspring. In addition, suppressing these inflammatory molecules ameliorates IH-induced tissue injury, providing new potential targets treat OSA-associated diseases. This review will focus the linking IH dysfunction pregnancies, their goal inspire further investigations into understudied females offspring, which ultimately uncover underlying therapeutic interventions for

Language: Английский

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Neuromuscular Fatigue Induced by Cycling at a Fixed Level of Perceived Effort: Effects of Different Purported Hypoxic Methods

Scandinavian Journal of Medicine and Science in Sports, Journal Year: 2025, Volume and Issue: 35(2)

Published: Feb. 1, 2025

ABSTRACT We compared neuromuscular fatigue induced by cycling at a fixed perceived effort in normoxic condition (NOR) and three purported hypoxia modalities: systemic (SyH, FiO 2 = 0.13), blood flow restriction (BFR, 50% arterial occlusion pressure) airflow mask (ARM, calibrated to ~3500 m). Seventeen healthy young participants cycled for 20 min self‐selected power output corresponding hard (15/20, Borg scale) on an innovative cycle ergometer allowing immediate evaluation. Isometric maximum voluntary contraction of the knee extensors (IMVC), central (voluntary activation, VA) peripheral were measured before every 5 during cycling. Power output, oxygen saturation (SpO ), quadriceps oxygenation (near‐infrared spectroscopy, TSI) pain assessed throughout was lower BFR SyH NOR ARM SyH. SpO reduced only (mean 77% ± 4%). In all conditions, IMVC decreased from minute subsequently plateaued (~−10% −20%), except BFR, wherein it further declined −40% 14% presence lowered VA exacerbated muscle other conditions. Muscle TSI Our results confirm inability induce hypoxia. Compared showed greater reduction VA, higher no deoxygenation. These underline psychophysiological impact both maximal submaximal motor output.

Language: Английский

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The Role of Hypoxia in Longevity

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Aging is marked by a progressive decrease in physiological function and reserve capacity, which results increased susceptibility to diseases. Understanding the mechanisms of driving aging crucial for extending health span promoting human longevity. Hypoxia, reduced oxygen availability, has emerged as promising area study within research. This review explores recent findings on potential restriction promote healthy extend lifespan. While role hypoxia-inducible factor 1 (HIF-1) cellular responses hypoxia well-established, its impact lifespan remains complex context-dependent. Investigations invertebrate models suggest HIF-1 longevity, while evidence mammalian limited. Hypoxia extends independent dietary (DR), known intervention underlying However, both DR converge common downstream effectors, such forkhead box O (FOXO) flavin-containing monooxygenase (FMOs) modulate Further work required elucidate molecular hypoxia-induced longevity optimize clinical applications. crosstalk between other longevity-associated pathways developing interventions enhance healthspan. Future studies may uncover novel therapeutic strategies populations.

Language: Английский

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Sleep-Disordered Breathing and Central Respiratory Control in Children: A Comprehensive Review

Children, Journal Year: 2025, Volume and Issue: 12(3), P. 279 - 279

Published: Feb. 25, 2025

Background/Objectives: Sleep-disordered breathing (SDB) is a primary concern in children’s health. Research suggests that repeated oxygen drops during sleep—common SDB—may harm the brainstem’s control centres. This damage likely occurs through oxidative stress, inflammation, and cell death, which weaken brain’s ability to regulate breathing. Over time, these effects could lead functional changes (e.g., disrupted chemical signalling) physical critical brain regions, creating cycle of unstable However, much this evidence comes from animal or lab studies, leaving gaps our understanding how mechanisms work humans. review synthesises existing research on disruptions sleep—particularly episodes intermittent hypoxia—affect respiration children adolescents. Methods: We analysed studies medical databases PubMed, Scopus, Web Science, focusing SDB (obstructive central sleep apnoea) impacts respiratory centres young populations. Animal involving mechanical ventilation were excluded focus natural patterns. Results: After removing duplicates, 54 remained. Additionally, 43 record for various reasons. Ultimately, 11 articles selected final analysis, including three focused genetic conditions, such as Down syndrome, Prader–Willi Pierre Robin sequence. The findings suggest dips may areas, especially developmental stages. long-term issues, breathing, cardiovascular strain, neurological problems. most only captured immediate low oxygen, uncertainty about permanent due lack follow-up. Conclusions: Repeated deprivation appears brainstem disrupt regulation. small study sizes short observation periods limit strength conclusions. Future should use advanced imaging tools clarify risks, develop effective treatments, track over extended periods. More significantly, longer-term are urgently needed guide clinical care vulnerable

Language: Английский

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Individualized Algorithm-Based Intermittent Hypoxia Improves Quality of Life in Patients Suffering from Long-Term Sequelae After COVID-19 Infection

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1590 - 1590

Published: Feb. 26, 2025

Background/Objectives: Post-COVID-19 condition (PCC), also known as long COVID, has emerged a recognized syndrome affecting millions of people worldwide, significantly impairing their quality life. Currently, no effective therapeutic options are available to manage this condition. The objective the present study was evaluate long-term effects personalized, algorithm-based intermittent hypoxia–hyperoxia conditioning (IHHC) on life and pain in patients with PCC. Methods: This open-label cohort included 199 PCC patients, aged 11–87 years (female-to-male ratio: 67:33) experiencing moderate-to-severe fatigue, between 1 January 2020 31 December 2023. Each patient received an treatment plan tailored demographics, symptom duration, baseline (NRS) (SF-36) scores. Patients average six sessions (range: 2–21), each consisting hypoxic–hyperoxic cycles, hypoxia (9–13% O2) lasting 3–8 min hyperoxia (34–36% 1–3 min. primary outcomes were changes NRS SF-36 scores at 6-week 6-month follow-ups. Results: At follow-up after initiation, increased by 102 points (p < 0.001, 95% CI: 78.4–127), improvement persisted (Δ106, p 57.0–154). Pain reduced 28–32% both time points, exceeding clinically relevant threshold. Health transition indicated patient-perceived health status. Conclusions: In study, IHHC alleviated improved suffering from persistent sequelae COVID-19 infection. sustained for up months. Further research is warranted elucidate mechanisms underlying IHHC’s population.

Language: Английский

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Closing the loop: Autonomous intelligent control for hypoxia pre-acclimatization and high-altitude health management

National Science Review, Journal Year: 2025, Volume and Issue: 12(5)

Published: March 7, 2025

Hypobaric hypoxia at high altitudes threatens the health of high-altitude residents. The development effective methods to guarantee safety frequent human activities in locations is therefore needed. Pre-acclimatization sea level an approach mitigate subsequent altitude sickness for rapid ascent, which offers a viable substitute on-site acclimatization, minimizes associated risks that are linked prolonged exposure environments and can be personalized individual hypoxic responses. Another critical aspect prevent long-term physical damage management altitudes, enabled by emerging technologies wearable sensors, Internet Medical Things artificial intelligence. In this review, we outline progress pre-acclimatization management, as well understanding physiological mechanisms under hypoxia, highlighting important role played sensors closed-loop control systems developing intelligent solutions. We also discuss challenges prospects deploying autonomous monitoring management.

Language: Английский

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The Catabolic - Anabolic Cycling Hormesis Model of Health and Resilience

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102588 - 102588

Published: Nov. 1, 2024

Language: Английский

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Adaptive Effects of Intermittent Hypoxia Training on Oxygen-Dependent Processes as a Potential Therapeutic Strategy Tool

Cellular Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 58(3), P. 226 - 249

Published: June 10, 2024

Background/Aims: Important benefits of intermittent hypoxic training (IHT) have emerged as an effective tool for enhancing adaptive potential in different pathological states, among which acute hypoxia dominates. Therefore, the aim our study was to evaluate mechanisms related effects nitric oxide system (nitrites, nitrates, carbamide, and total polyamine content) on ADP-stimulated oxygen consumption oxidative phosphorylation heart liver mitochondria biomarkers stress blood, heart, rats exposed IHT method treated with amino acid L-arginine (600 mg/kg, 30 min) or NO synthase inhibitor L-NNA (35 prior each session. Methods: We analysed modulation oxygen-dependent processes (mitochondrial respiration oxygraphic method, microsomal oxidation, lipoperoxidation using biochemical methods) tissues during formation short-term long-term (30, 60, 180 days after last session) simultaneous administration L-arginine. In particular, we investigated how mitochondrial functions are modulated use oxidation substrates (succinate α-ketoglutarate) bioenergetic cellular stability adaptation. Results: The is associated a significant increase production endogenous measured by levels its stable metabolite, nitrite anion, both plasma (almost 7-fold) erythrocytes (more than rats. intensification oxide-dependent pathways metabolic transformations energy supply liver, accompanied oscillatory adaptation interval mode, causes probable decrease urea polyamines but not erythrocytes. sessions increased level nitrite-reducing component cycle, persisted up experiment. Conclusion: Thus, efficacy nitrite-dependent shown this responses preventing due pronounced changes main enzymes antioxidant defence stabilisation erythrocyte membranes, has protective effect regulation whole.

Language: Английский

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Effects of Intermittent Hypoxia Protocols on Cognitive Performance and Brain Health in Older Adults Across Cognitive States: A Systematic Literature Review

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 101(1), P. 13 - 30

Published: July 30, 2024

Background: The rise in the aging population highlights need to address cognitive decline and neurodegenerative diseases. Intermittent hypoxia (IH) protocols show promise enhancing abilities brain health. Objective: This review evaluates IH protocols’ benefits on cognition health older adults, regardless of status. Methods: A systematic search following PRISMA guidelines was conducted across four databases (PubMed, Scopus, Web Science, Cochrane Library) two registers, covering records from inception May 2024 (PROSPERO: CRD42023462177). Inclusion criteria were: 1) original research with quantitative details; 2) studies involving or without impairment; 3) including protocols; 4) articles analyzing adults. Results: Seven five registered trials met criteria. Findings indicate that Hypoxia Training (IHT) Hypoxia-Hyperoxia (IHHT) improved functions Hypoxic Exposure (IHE) cerebral tissue oxygen saturation, middle arterial flow velocity, vascular conductance, particularly cognitively impaired populations. IHT IHHT had no significant effect BDNF levels. There is a lack IHHE adults impairment. Conclusions: may benefit IHE positively affect outcomes, all having limited effects Future should standardize protocols, investigate long-term effects, explore neuroprotective biomarkers. Combining these physical exercise diverse populations could refine interventions guide targeted therapeutic strategies.

Language: Английский

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