Surface plasmon resonance detection of anti-cancer drug flutamide by graphitic carbon nitride/chitosan nanocomposite

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

The g-C3N4/CS biosensor was designed, fabricated, and tested using compounds such as glucose, urine, lactose, flutamide at a molarity of 10 µM, which could demonstrate high sensitivity 200 μm-1 for flutamide. Powerful effective medium theory FDTD simulation were used to predict the most favorable mode plasmonic properties graphite carbon nitride chitosan nanocomposite. research also explores characteristics surface plasmon resonance exhibited by nanocomposite content is adjusted. Subsequent simulations are conducted on nanocomposites incorporating thin layer modified gold structure. intricate ultimately reveal optimal combination, under three different pH conditions (6.2, 7.2, 8). In acidic conditions, kinetic profile yielded KD= 3.45 × 10−7, surpassing KD value film. Au significantly outperformed alternative material. demonstrated linear behavior across wide concentration range from 1 150 achieving detection limit 120 nM with its sensitivity.

Language: Английский

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Valorization of grape pomace extracts against cranberry, elderberry, rose hip berry, goji berry and raisin extracts: Phytochemical profile and in vitro biological activity

Food Chemistry, Journal Year: 2024, Volume and Issue: 463, P. 141323 - 141323

Published: Sept. 19, 2024

Language: Английский

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Lycopene enriched extra virgin olive oil: Biological activities and assessment of security profile on cells

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104466 - 104466

Published: June 1, 2024

The production of tomato products is massive in Italy resulting a huge amount waste as seeds, peels and stems. aim our work to re-utilize these matrices through the extraction carotenoids, especially lycopene obtain enriched extra virgin olive oil (EVOO). has been obtained by ultrasound-assisted (UAE) technique using directly solvent, due its lipophilic nature. quantification done HPLC-DAD, good concentration per gram (0.9 mg/g oil). Then EVOO was evaluated vitro determine antioxidant enzyme inhibitory activity comparison with itself. These data were associated cytotoxicity assays vivo histological bioassays, aiming highlight safe healthy profile on human normal cells.

Language: Английский

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Phytochemical analysis and acute toxicity of Solanum elaeagnifolium extract in Swiss albino mice

Scientific African, Journal Year: 2024, Volume and Issue: 24, P. e02212 - e02212

Published: April 6, 2024

The curative effects of Solanum elaeagnifolium have aroused the interest botanical medicine researchers. However, no research has been carried out into its potential toxicity. aim this study was firstly to screen secondary metabolites contained in leaves and fruits S. their mineralogical composition, secondly assess acute oral toxicity Swiss albino mice. amount minerals plant powder assessed by inductively coupled plasma atomic emission spectrometry, phytochemical screening performed. hydroethanolic extracts were prepared using maceration method. Acute according OECD guideline 423. Mice given leaf (SEFE) fruit (SEFR) once at doses 500 mg/kg, 1000 mg/kg 2000 an study. animals then monitored for 14 days. To rule any toxicity, general behavior animals, clinical symptoms poisoning, body weight, biochemical hematological markers, liver, kidney, spleen histology examined. two different comprised very important elements such as Mg, Zn, k, well polyphenols flavonoids, these chemical shown biological activities. An administration a extract dose resulted death We found significant difference weight For less than markers kidneys, hematology did not differ significantly from those control group. Furthermore, there changes markers. architecture spleen, kidney normal histopathological analysis reveal adverse effects. These findings indicate that harbors array minerals. exhibited signs induced histological, hematological, alterations weight. comprehensive studies will help improve our understanding elaeagnifolium's safety utility, laying groundwork safe use variety settings.

Language: Английский

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Evaluation of Adaptive Responses of Juglans neotropica Diels Progenies Based on Dasometric Traits

International Journal of Plant Biology, Journal Year: 2025, Volume and Issue: 16(1), P. 26 - 26

Published: Feb. 24, 2025

(1) Background: Juglans neotropica Diels, native to the Andes, is highly valued for its quality wood, medicinal uses, edible fruits, and natural dyes. However, population has been greatly reduced due overexploitation, becoming threatened resulting in genetic stochasticity. Therefore, a prompt ex situ conservation effort needed restoration. (2) Methods: A total of 439 trees J. Diels were sampled from selected individuals across northern central regions Ecuador. These planted randomized complete block design assess their growth variability. (3) Results: Annual average tree varied significantly among progenies. Based on dasometric traits, two distinct groups identified as superior surveillance. Five demonstrated promising traits (TJ182, ChL2314, ChL142, TJ1310, BSM14), suggesting potential inclusion forest improvement programs. (4) Conclusions: Fifteen percent five studied provenances exhibited desirable characteristics high-quality wood. In addition, several within progenies exhibit resistance biotic agents, indicating disease.

Language: Английский

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Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1080 - 1080

Published: March 21, 2025

Insomnia affects one-third of the world’s population; negative effects insomnia are significant, and traditional medications have numerous side cause considerable suffering. This has aroused interest in obtaining sleep-improving substances from foods. study conducted a comprehensive literature review using Web Science PubMed with keywords like “sleep”, “insomnia”, “food”. A subsequent summary revealed that certain foods, including milk, Ziziphus jujuba, Lactuca sativa, ginseng, Schisandra chinensis, Juglans regia, etc., purported to enhance sleep quality by prolonging duration, reducing latency, alleviating anxiety. The mechanisms these foods’ mainly occur via central nervous system, particularly gamma-aminobutyric acid (GABA)ergic 5-hydroxytryptamine (5-HT)ergic systems. Although this supports fact they potential, further research is needed. There also issues such as more limited fewer mechanisms, pharmacokinetic studies, models being involved. These need be addressed future adequately address problem insomnia. It hoped will contribute into foods properties and, future, provide an effective natural alternative for those seeking medication.

Language: Английский

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Exploring the use of phytotherapy in benign prostatic hyperplasia [BPH]: a systematic review

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 412 - 412

Published: April 8, 2025

Background Benign prostatic hyperplasia [BPH] is a prevalent condition among aging men, characterized by prostate gland enlargement leading to lower urinary tract symptoms [LUTS]. Conventional treatments like alpha-blockers and 5-alpha-reductase inhibitors, though effective, often result in adverse effects. This has spurred interest phytotherapy, leveraging plant-derived compounds mitigate BPH due their safety, cost-effectiveness, patient preference. Method The review highlighted 84 studies involving diverse plants bioactive compounds. Prominent examples include Serenoa repens [saw palmetto], Urtica dioica [nettle root], Cucurbita pepo [pumpkin seed], Pygeum africanum [African cherry]. These exhibit mechanisms such as 5α-reductase inhibition, anti-inflammatory effects, modulation of oxidative stress. Clinical preclinical findings demonstrate improved flow, reduced volume, alleviated LUTS. However, variability methodologies, extract preparations, dosages poses challenges standardization. Results Serenoa repens Cucurbita pepo Pygeum africanum Conclusion Phytotherapy holds significant potential management, offering symptom relief with minimal side While promising, further robust clinical trials are essential validate efficacy, establish standardized protocols, ensure integration into mainstream therapeutic frameworks.

Language: Английский

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Phytochemical analysis and antioxidant potential of Mondia whitei and Guibourtia tessmannii against H ₂ O ₂ -induced cytotoxicity in PC3 cells

Journal of Biomolecular Structure and Dynamics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: April 23, 2024

The management of oxidative stress-related disorders has garnered significant interest, particularly in the exploration medicinal plants possessing potent antioxidant activities. This study was undertaken to evaluate activity Mondia whitei (MW) and Guibourtia tessmannii (GT) against H2O2-induced cytotoxicity PC3 cells. phytochemical composition MW GT determined by GC-MS analysis. Total phenolic (TP) total flavonoid (TF) contents were quantified Folin Ciocalteu AlCl3 methods, respectively. potential extracts using DPPH ABTS+ radicals scavenging method, as well cupric ferric reducing capacity assay. Moreover, all phytocompounds docked acetylcholinesterase (AChE) glutathione S-transferase (GST) ArgusLab, results analyzed BIOVIA Discovery Studio Visualizer 2021 client. comprised 20 22 compounds, exhibited higher TP TF (210.70 ± 12.7; 12.61 1.3 GAE/g DW) compared (132.59 12.59; 5.53 mg DW). Both demonstrated substantial activity, with proving be more effective preventing cytotoxicity. For instance, significantly (p < .001) increased DPPH, ABTS+, H2O2 group. All compounds identified a strong binding affinity AChE GST. Drug likeness toxicity under acceptable norms Lipinski's rule. In conclusion, these could candidates for management/treatment disorders.

Language: Английский

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Industrial importance seed kernel of Buchanania lanzan in contributing antioxidant, antidiabetic, and anticholinesterase activities

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 104135 - 104135

Published: April 17, 2024

Language: Английский

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Antiproliferative Effects of Ajuga orientalis Methanolic Extract: In Vitro and In Silico Insights

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(41)

Published: Oct. 28, 2024

Abstract Ajuga orientalis , a perennial herb from the Lamiaceae family, is traditionally used in Jordanian folk medicine for its therapeutic properties. This study evaluates phytochemical profile, cytotoxicity, drug‐likeness, and molecular docking of methanolic extract A. to explore potential as source novel agents. GC‐MS analysis identified 21 compounds, including oleic acid methyl ester (27.1%) palmitic (12.5%). The demonstrated significant concentration‐dependent cytotoxicity against RAW264.7 macrophage cells, with an IC 50 91.5 µg/mL. Molecular studies revealed fundamental interactions phytochemicals cancer‐related proteins, VEGFR2 TLR4/MD‐2, showing strong binding affinities. Notably, 1,7‐di(2,5‐dimethylphenyl)‐2,2,4,4,6,6‐hexamethyl‐1,3,5,7‐tetraoxa‐2,4,6‐trisilaheptane 2TBDMS derivative 4‐hydroxybenzeneacetic exhibited promising interactions, indicating inhibiting angiogenesis modulating immune responses. Drug‐likeness evaluation 18 compounds showed that 11 meet criteria oral bioavailability, though some challenges drug development remain. research underscores cancer treatment modulation, suggesting further experimental validation these bioactive compounds.

Language: Английский

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