Polyphenols: A concise overview on the chemistry, occurrence, and human health

Phytotherapy Research, Journal Year: 2019, Volume and Issue: 33(9), P. 2221 - 2243

Published: July 29, 2019

This review gives an updated picture of each class phenolic compounds and their properties. The most common classification implies the subdivision phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, isoflavones) non‐flavonoids acids, xanthones, stilbens, lignans, tannins) polyphenols. great interest polyphenols is associated with high potential application for food preservation therapeutic beneficial use. relationship between polyphenol intake human health has been exploited special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, cancer. use current existing databases bioactive including described as key tools research.

Language: Английский

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Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)

Molecular Medicine Reports, Journal Year: 2020, Volume and Issue: 22(1), P. 9 - 19

Published: May 5, 2020

Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are a group of viruses that cause infections in the human respiratory tract, which can be characterized clinically from mild to fatal. The severe acute syndrome coronavirus 2 (SARS‑CoV‑2) is virus responsible. global spread COVID‑19 described as worst pandemic humanity last century. To date, has infected more than 3,000,000 people worldwide and killed 200,000 people. All age groups virus, but serious symptoms possibly result death observed older those with underlying medical conditions such cardiovascular pulmonary disease. Novel data report even negative prognosis for obese patients. A growing body evidence connects obesity number mechanisms immune system activity attenuation chronic inflammation implicated. Lipid peroxidation creates reactive lipid aldehydes patient metabolic disorder will affect its prognosis. Finally, pregnancy‑associated needs studied further connection this infection could pose high risk both pregnant women fetus.

Language: Английский

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The Akt pathway in oncology therapy and beyond (Review)

International Journal of Oncology, Journal Year: 2018, Volume and Issue: unknown

Published: Oct. 16, 2018

Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell death and survival, playing a pivotal role in multiple interconnected signaling mechanisms implicated metabolism, growth division, apoptosis suppression angiogenesis. Akt displays important metabolic effects, among which are glucose uptake muscle fat cells or neuronal death. Disruptions Akt‑regulated pathways associated with cancer, diabetes, cardiovascular neurological diseases. The regulation pathway renders valuable therapeutic target. discovery process inhibitors using various strategies has led identification great selectivity, low side‑effects toxicity. usefulness emerges beyond cancer therapy extends major diseases, such as heart neurodegeneration. This review presents key features structure functions, progress regards drug development, their preclinical clinical activity efficacy safety for patients.

Language: Английский

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Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis

Food and Chemical Toxicology, Journal Year: 2018, Volume and Issue: 113, P. 49 - 65

Published: Feb. 2, 2018

Language: Английский

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Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

Nutrients, Journal Year: 2021, Volume and Issue: 13(1), P. 206 - 206

Published: Jan. 12, 2021

Polyphenols (PPs) are the naturally occurring bioactive components in fruits and vegetables, they most abundant antioxidant human diet. Studies suggesting that ingestion of PPs might be helpful to ameliorate metabolic syndromes may contribute prevention several chronic disorders like diabetes, obesity, hypertension, colon cancer. have structural diversity which impacts their bioavailability as accumulate large intestine extensively metabolized through gut microbiota (GM). Intestinal transforms into metabolites make them bioactive. Interestingly, not only GM act on metabolize but also modulate composition GM. Thus, change from pathogenic beneficial ones health associated diseases. However, overcome low PPs, various approaches been developed improve solubility transportation gut. In this review, we present evidence supporting changes occur after reactions (curcumin, quercetin, catechins) effect leads improving overall helping disorders.

Language: Английский

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Bioactive and functional compounds in apple pomace from juice and cider manufacturing: Potential use in dermal formulations

Trends in Food Science & Technology, Journal Year: 2019, Volume and Issue: 90, P. 76 - 87

Published: May 31, 2019

Language: Английский

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Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 16, 2020

Gallic acid (GA) is a naturally occurring polyphenol compound present in fruits, vegetables, and herbal medicines. According to previous studies, GA has many biological properties, including antioxidant, anticancer, anti-inflammatory, antimicrobial properties. its derivatives have multiple industrial uses, such as food supplements or additives. Additionally, recent studies shown that not only enhance gut microbiome (GM) activities, but also modulate immune responses. Thus, great potential facilitate natural defense against microbial infections the response. However, exact mechanisms of acts on GM system remain unclear. In this review, first physicochemical bioavailability, absorption, metabolism are introduced, then we summarize findings concerning roles gastrointestinal health. Furthermore, review attempts explain how influences modulates response maintain intestinal

Language: Английский

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Antiviral activity of plants and their isolated bioactive compounds: An update

Phytotherapy Research, Journal Year: 2019, Volume and Issue: 34(4), P. 742 - 768

Published: Dec. 19, 2019

Viral infections represent one of the main causes disease worldwide, especially today due to increase migration, global travel, and urbanization. The several side effects conventional drugs growing phenomenon resistance have led researchers turn plant kingdom as a source potential new antiviral drugs. aim this work is summarize updated evidence for activity different plants their isolated bioactive compounds, evaluating also interactions, which can occur in cotreatment with complexes proved be usually more active than most abundant compounds by hypothesizing synergistic mechanisms. In addition cellular molecular investigations, docking studies essential highlighting interaction mechanisms target molecules. However, use nonstandardized extracts, or too high concentrations vitro, do not reproduce bioavailability vivo, are often limiting factors. Moreover, lack concerning safety profile extracts alone combination drugs, worrying aspect. light this, further needed validate possible therapeutic use.

Language: Английский

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Polyphenols in cancer prevention: New insights (Review)

International Journal of Functional Nutrition, Journal Year: 2020, Volume and Issue: 1(2)

Published: Oct. 5, 2020

A huge volume of literature data suggests that a diet rich in fruits and vegetables, mostly due to the contribution natural polyphenols, could reduce incidence specific cancers. Resveratrol, epigallocatechin gallate curcumin are among most extensively studied polyphenols: The majority effects attributed these compounds linked their antioxidant anti‑inflammatory properties. multiple mechanisms involved include modulation molecular events signaling pathways associated with cell survival, proliferation, differentiation, migration, angiogenesis, hormonal activities, detoxification enzymes immune responses. Notwithstanding promising role cancer prevention treatment, polyphenols often have poor bioavailability when administered as pure active principles, representing an important limit use. However, thus efficacy can be improved by administration combination other phytochemicals, anticancer drugs or polyphenol‑loaded nanotechnology‑based delivery systems. possibility combining conventional offers very valuable advantages, such building more efficient therapies less side‑effects on health patients. present review focuses current knowledge regarding interactions between development order gain clearer comprehension potential through which individual foods food components may exploited risk.

Language: Английский

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Polyphenols in Metabolic Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(19), P. 6280 - 6280

Published: Sept. 23, 2022

Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic effects, and possible health benefits in vivo vitro, as well reported clinical studies. Considering their free-radical scavenging anti-inflammatory these substances can be used to treat different kinds conditions associated metabolic disorders. Many symptoms syndrome (MtS), including obesity, dyslipidemia, atherosclerosis, elevated blood sugar, accelerating aging, liver intoxication, hypertension, cancer neurodegenerative disorders, substantially relieved by dietary PPs. The present study explores the bioprotective properties underlying mechanisms A detailed understanding natural compounds will open up new opportunities for producing unique PP-rich medicinal plans, ultimately affirming benefits.

Language: Английский

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