Health Benefits of Quercetin in Age-Related Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(8), P. 2498 - 2498

Published: April 13, 2022

Polyphenols are the known group of phytochemicals that essentially consists phenolic rings. These plant product present in varied fruits and vegetables. secondary metabolites perform a protective function plants from environmental biological stress. When consumed as human diet these also to prevent various age-associated diseases. possess antioxidant properties protect against oxidative The literature survey was carried out using databases such PubMed, Science direct Springer. research articles last 10-12 years were selected for this review based on its relevancy with topic. mainly focused quercetin health benefits. highlights main functions flavonoid, quercetin. Quercetin is among widely occurring polyphenol, found abundantly nature. It commonly different products. Onion have highest quantity This compound possessed considered aging. be both free conjugated forms. has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, anti-viral properties. molecule lipophilic can easily cross BBB (Blood-Brain Barrier) hence protects neurodegenerative Various vivo vitro studies demonstrated role here detailed curative agent neurodegeneration, diabetes, cancer, inflammation been out. Studies proved plays crucial prevention age-related disorders. potent which currently being used pharmaceuticals. Properties further explored other Nanoformulations liposomal formulations made treat age associated

Language: Английский

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Potential Implications of Quercetin in Autoimmune Diseases

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: June 23, 2021

Autoimmune diseases are a worldwide health problem with growing rates of morbidity, and characterized by breakdown dysregulation the immune system. Although their etiology pathogenesis remain unclear, application dietary supplements is gradually increasing in patients autoimmune diseases, mainly due to positive effects, relatively safety, low cost. Quercetin natural flavonoid that widely present fruits, herbs, vegetables. It has been shown have wide range beneficial effects biological activities, including anti-inflammation, anti-oxidation, neuroprotection. In several recent studies quercetin reportedly attenuated rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus humans or animal models. This review summarizes evidence for pharmacological which supports view may be useful prevention treatment.

Language: Английский

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Multifaceted roles of flavonoids mediating plant-microbe interactions

Microbiome, Journal Year: 2022, Volume and Issue: 10(1)

Published: Dec. 16, 2022

Plant-microbe interactions dynamically affect plant growth, health, and development. The mechanisms underpinning these associations are-to a large extent-mediated by specialized host-derived secondary metabolites. Flavonoids are one of the most studied classes such metabolites, regulating both development interaction with commensal microbes. Here, we provide comprehensive review multiple roles flavonoids in mediating plant-microbe interactions. First, briefly summarize general aspects flavonoid synthesis, transport, exudation plants. Then, importance influencing overall community assembly plant-root microbiomes. Last, highlight potential knowledge gaps our understanding how determine between plants Collectively, advocate advancing research this area toward innovative strategies to effectively manipulate plant-microbiome composition, case, via production roots. Video Abstract.

Language: Английский

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Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 36(1), P. 189 - 213

Published: Oct. 25, 2021

Abstract Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor activity, which has shown significant efficacy in pre‐clinical and clinical studies. stimulates cell death, triggers cycle arrest, suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) DNA damage apoptosis chemotherapy. However, CP adverse effects on several organs of the body, drug resistance frequently observed. The purpose present review to show function curcumin decreasing CP's impacts improving its antitumor activity. administration reduces ROS levels prevent normal cells. Furthermore, can inhibit inflammation via down‐regulation NF‐κB maintain organs. nanoformulations reduce hepatoxicity, neurotoxicity, renal toxicity, ototoxicity, cardiotoxicity caused by CP. Notably, potentiates cytotoxicity mediating death arrest. Besides, STAT3 NF‐ĸB as tumor‐promoting enhance sensitivity resistance. targeted delivery tumor cells be mediated nanostructures. In addition, derivatives are also able CP‐mediated side effects, increase against various types.

Language: Английский

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Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 690 - 690

Published: Feb. 21, 2021

The gut microbiota (GM) represents a diverse and dynamic population of microorganisms about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest GM can influence health host, several factors modify composition, such as diet, drug intake, lifestyle, geographical locations. Gut dysbiosis affect brain immune homeostasis through microbiota-gut-brain axis play key role pathogenesis neurodegenerative diseases, including dementia Alzheimer's disease (AD). relationship between AD is still elusive, but emerging evidence suggests it enhance secretion lipopolysaccharides amyloids may disturb intestinal permeability blood-brain barrier. In addition, promote hallmarks AD, oxidative stress, neuroinflammation, amyloid-beta formation, insulin resistance, ultimately causation neural death. Poor dietary habits aging, along with inflammatory responses due to dysbiosis, contribute AD. Thus, modulation probiotics, or fecal transplantation could represent potential therapeutics this review, we discuss therapeutic strategies modulate

Language: Английский

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Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(7), P. 3715 - 3715

Published: April 2, 2021

The human intestine contains an intricate community of microorganisms, referred to as the gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple factors could interfere with this delicate balance, including genetics, age, medicines and environmental factors, particularly diet. Growing evidence supports involvement GM dysbiosis gastrointestinal (GI) extraintestinal metabolic diseases. beneficial effects dietary polyphenols preventing diseases have been subjected intense investigation over last twenty years. As our understanding advances knowledge antioxidant anti-inflammatory functions accumulates, there emerges need examine prebiotic polyphenols. This review firstly overviews importance health disease then reviews on modulation microbiota, their metabolites how they impact benefits. Inter-dependence between polyphenol vital balance two maintaining homeostasis are also discussed.

Language: Английский

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Nutraceuticals and Cancer: Potential for Natural Polyphenols

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 3834 - 3834

Published: Oct. 27, 2021

Cancer is one of the leading causes death globally, associated with multifactorial pathophysiological components. In particular, genetic mutations, infection or inflammation, unhealthy eating habits, exposition to radiation, work stress, and/or intake toxins have been found contribute development and progression cancer disease states. Early detection proper treatment enhance chances survival healing, but side effects anticancer drugs still produce detrimental responses that counteract benefits in terms hospitalization survival. Recently, several natural bioactive compounds were possess properties, capable killing transformed cancerous cells without being toxic their normal counterparts. This effect occurs when products are conventional treatments, thereby suggesting nutraceutical supplementation may successful therapy. review aims discuss current literature on four extracts mostly characterized by a specific polyphenolic profile. activities reported support treatment: (1) inhibition cell proliferation, (2) antioxidant activity, (3) anti-inflammatory activity. On other hand, owing attenuation therapies, antioxidants improving compliance patients undergoing treatment. Thus, supplementation, along drug treatment, be considered for better cancer. It should noted, however, data from studies plant preparations discussed, it appropriate ensure experiments conducted accordance accepted pharmacological research practices so as not disclose information only partially correct.

Language: Английский

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Polyphenols in Metabolic Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(19), P. 6280 - 6280

Published: Sept. 23, 2022

Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic effects, and possible health benefits in vivo vitro, as well reported clinical studies. Considering their free-radical scavenging anti-inflammatory these substances can be used to treat different kinds conditions associated metabolic disorders. Many symptoms syndrome (MtS), including obesity, dyslipidemia, atherosclerosis, elevated blood sugar, accelerating aging, liver intoxication, hypertension, cancer neurodegenerative disorders, substantially relieved by dietary PPs. The present study explores the bioprotective properties underlying mechanisms A detailed understanding natural compounds will open up new opportunities for producing unique PP-rich medicinal plans, ultimately affirming benefits.

Language: Английский

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Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients, Journal Year: 2022, Volume and Issue: 14(17), P. 3519 - 3519

Published: Aug. 26, 2022

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin received the most attention among these molecules due to their documented antioxidant effects. The review aims investigate effects of on bone metabolism role in several diseases such as osteopenia osteoporosis, tumours, periodontitis. PubMed/Medline, Web Science, Google Scholar, Scopus, Cochrane Library, Embase electronic databases were searched for papers line with study topic. According an English language restriction, screening period was from January 2012 3 July 2022, following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” (“quercetin” “bone”). A total 36 identified relevant purpose our investigation. studies positive investigated phenolic potential application adjuvant treatments Furthermore, use titanium surfaces orthopaedic prostheses could represent a possible improve osteogenic processes osseointegration. findings, resveratrol, wide variety beneficial supplement therapies. seem positively mediate osteoclast-related pathologies.

Language: Английский

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The roles of catechins in regulation of systemic inflammation

Food Science and Biotechnology, Journal Year: 2022, Volume and Issue: 31(8), P. 957 - 970

Published: March 24, 2022

Language: Английский

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