Cuproptosis scoring system to predict the clinical outcome and immune response in bladder cancer

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 4, 2022

Cuproptosis is a novel copper ion-dependent cell death type being regulated in cells, and this quite different from the common patterns such as apoptosis, pyroptosis, necroptosis, ferroptosis. Interestingly, like with patterns, cuproptosis-related genes have recently been reported to regulate occurrence progression of various tumors. However, bladder cancer, link between cuproptosis clinical outcome, tumor microenvironment (TME) modification, immunotherapy unknown. To determine role cuprotosis microenvironment, we systematically examined characteristic 10 cancer (BLCA). By analyzing principal component data, established score degree among patients. Finally, evaluated potential these values predicting BLCA prognosis treatment responses. A comprehensive study mutations specimens was conducted at genetic level, their expression survival were using The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). Two constructed based on transcription level genes, featuring differences infiltrating landscape immune cells (especially T dendritic cells) interactions TME. Our further demonstrated that may predict prognosis, immunophenotype sensitivity chemotherapy, response development are likely be influenced by cuproptosis, which involve diverse complex pattern our enhance understanding infiltrations guide more potent interventions.

Language: Английский

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COVID-19 and Selenium Deficiency: a Systematic Review

Biological Trace Element Research, Journal Year: 2021, Volume and Issue: 200(9), P. 3945 - 3956

Published: Nov. 5, 2021

Abstract Several studies have indicated that selenium deficiency may be detrimental in the context of various viral disorders, and case COVID-19, several reported heterogeneous results concerning association with severity disease. To summarize available data surrounding body levels outcomes a systematic search was performed Medline database (PubMed), Scopus, Cochrane Library, Embase, Web Science using keywords including “SARS-CoV-2,” “COVID-19,” “selenium,” Studies evaluating COVID-19 were included. Among 1,862 articles viewed search, 10 included after title, abstract, full-text review. One study further searching literature again for any newly published articles. Out 11 studies, measured serum level, one investigated urinary level. Three SELENOP level as well Glutathione peroxidase-3 also assessed study. The severity, mortality, risk COVID-19. Nine lower is associated worse outcomes. Two no significant between In study, to higher severe fatal cases compared non-severe recovered patients, respectively. most cases, outcomes, patients than healthy individuals. Thus, it could concluded cautious supplementation helpful prevent disease progression. However, randomized clinical trials are needed confirm this.

Language: Английский

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Selenium and immune function: a systematic review and meta-analysis of experimental human studies

American Journal of Clinical Nutrition, Journal Year: 2022, Volume and Issue: 117(1), P. 93 - 110

Published: Dec. 19, 2022

Language: Английский

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Comparative versatility and diverse biological applications of eco-friendly zinc oxide and cobalt oxide nanoparticles using Punica granatum L. peel extract

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 38, P. 101174 - 101174

Published: May 1, 2024

Language: Английский

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Inspirations of Cobalt Oxide Nanoparticle Based Anticancer Therapeutics

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(10), P. 1599 - 1599

Published: Oct. 2, 2021

Cobalt is essential to the metabolism of all animals due its key role in cobalamin, also known as vitamin B12, primary biological reservoir cobalt an ultra-trace element. Current cancer treatment strategies, including chemotherapy and radiotherapy, have been seriously restricted by their side effects low efficiency for a long time, which urges us develop new technologies more effective much safer anticancer therapies. Novel nanotechnologies, based on different kinds functional nanomaterials, proved act promising strategies treatment. Based important roles cobalt, oxide nanoparticles (NPs) widely developed attractive biomedical applications, especially potential treatments selective inhibition cells. Thus, attention has attracted preparation, characterization investigation recent years, expected introduce novel strategies. In this review, we summarize synthesis methods discuss advantages restrictions preparation. Moreover, emphatically functions well underlying mechanisms promote development treatments, might finally benefit current therapeutics nanoparticles.

Language: Английский

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Transmission of viruses and other pathogenic microorganisms via road dust: Emissions, characterization, health risks, and mitigation measures

Atmospheric Pollution Research, Journal Year: 2022, Volume and Issue: 14(1), P. 101642 - 101642

Published: Dec. 31, 2022

Language: Английский

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Essential metals, vitamins and antioxidant enzyme activities in COVID-19 patients and their potential associations with the disease severity

BioMetals, Journal Year: 2022, Volume and Issue: 35(1), P. 125 - 145

Published: Jan. 7, 2022

Language: Английский

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Assessment of the Ecotoxicity of Pollution by Potentially Toxic Elements by Biological Indicators of Haplic Chernozem of Southern Russia (Rostov region)

Water Air & Soil Pollution, Journal Year: 2022, Volume and Issue: 233(1)

Published: Jan. 1, 2022

Language: Английский

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Heavy Metal(oid)s Contamination and Potential Ecological Risk Assessment in Agricultural Soils

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(2), P. 634 - 650

Published: May 14, 2024

Soil pollution caused by heavy metal(oid)s has generated great concern worldwide due to their toxicity, persistence, and bio-accumulation properties. To assess the baseline data, metal(oid)s, including manganese (Mn), iron (Fe), Cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), lead (Pb), mercury (Hg), chromium (Cr), cadmium (Cd), were evaluated in surface soil samples collected from farmlands of Grand Forks County, North Dakota. Samples digested via acid mixture analyzed inductively coupled plasma mass spectrometry (ICP MS) analysis levels, ecological risks, possible sources. The metal(oid) median levels exhibited following decreasing trend: Fe > Mn Zn Ni Cr Cu Pb Co As Cd Hg. Principal component (PCA) hierarchical cluster (HCA) suggested main lithogenic source for studied metal(oid)s. Metal(oid) current investigation, except Mn, are lower than most guideline values set international agencies. contamination factor (Cf), geo accumulation index (Igeo) enrichment (EF) showed considerable contamination, moderate significant enrichment, respectively, on value basis. Ecological risk (Er) results low all Cd, which risk. potential (PERI) indicated Overall, indicate study area. high nutrients soils potentially affect crops impact consumers’ health. This drives impetus continued environmental monitoring programs.

Language: Английский

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The prognostic role of micronutrient status and supplements in COVID-19 outcomes: A systematic review

Food and Chemical Toxicology, Journal Year: 2022, Volume and Issue: 162, P. 112901 - 112901

Published: Feb. 25, 2022

Language: Английский

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