Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Cells, Journal Year: 2023, Volume and Issue: 12(14), P. 1888 - 1888

Published: July 19, 2023

The intestinal barrier is a precisely regulated semi-permeable physiological structure that absorbs nutrients and protects the internal environment from infiltration of pathological molecules microorganisms. Bile acids are small synthesized cholesterol in liver, secreted into duodenum, transformed to secondary or tertiary bile by gut microbiota. interact with acid receptors (BARs) microbiota, which plays key role maintaining homeostasis barrier. In this review, we summarize discuss recent studies on disorder associated dysfunction related diseases. We focus roles acids, BARs, microbiota triggering dysfunction. Insights for future prevention treatment diseases provided.

Language: Английский

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Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106662 - 106662

Published: Jan. 13, 2025

Language: Английский

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TEC-mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 21, 2025

Tectorigenin (TEC) is a monomer of anthocyanin, which we found exhibits hepatoprotective effects. tRNA-derived fragments (tRFs) and ferroptosis play important roles in the pathogenesis non-alcoholic steatohepatitis (NASH). Recent discoveries have revealed that histone lactylation acetylation crucial role connecting cellular metabolism epigenetic regulation through post-translational modification histones. However, it unclear whether TEC improves NASH by regulating lactylation, hepatocyte tRFs. In this study, demonstrated significantly inhibits free fatty acids-induced both vitro vivo. We identified tRF-31R9J (tRF-31-R9JP9P9NH5HYD) involved steatosis hepatocytes. Overexpression suppressed enhanced cell viability HepG2 cells. Knockdown partially counteracted inhibitory effect on Mechanistically, recruited HDAC1 to reduce levels modifications pro-ferroptosis genes ATF3, ATF4, CHAC1, thereby inhibiting their gene expression. This study demonstrates TEC-mediated HDAC1-regulated delactylation deacetylation, improving NASH. These offer theoretical foundation new strategies for medical management

Language: Английский

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Chronic lead exposure exacerbates hepatic glucolipid metabolism disorder and gut microbiota dysbiosis in high-fat-diet mice

Food and Chemical Toxicology, Journal Year: 2022, Volume and Issue: 170, P. 113451 - 113451

Published: Oct. 2, 2022

Language: Английский

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Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics

Molecules, Journal Year: 2023, Volume and Issue: 28(15), P. 5904 - 5904

Published: Aug. 5, 2023

Tectorigenin is a well-known natural flavonoid aglycone and an active component that exists in numerous plants. Growing evidence suggests tectorigenin has multiple pharmacological effects, such as anticancer, antidiabetic, hepatoprotective, anti-inflammatory, antioxidative, antimicrobial, cardioprotective, neuroprotective. These properties provide the basis for treatment of many kinds illnesses, including several types cancer, diabetes, hepatic fibrosis, osteoarthritis, Alzheimer’s disease, etc. The purpose this paper to comprehensive summary review sources, extraction synthesis, toxicity, pharmacokinetics, delivery strategy aspects tectorigenin. may exert certain cytotoxicity, which related administration time concentration. Pharmacokinetic studies have demonstrated main metabolic pathways rats are glucuronidation, sulfation, demethylation methoxylation, but it exhibits poor bioavailability. From our perspective, further research on should cover: exploring targets mechanisms action; finding appropriate concentration balance effects toxicity; attempting diversified strategies improve bioavailability; structural modification obtain derivatives with higher activity.

Language: Английский

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Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(24), P. 9370 - 9380

Published: June 8, 2023

Non-alcoholic steatohepatitis (NASH) has become the most important reason of liver disease around world and is predisposed to further progression cirrhosis hepatocellular carcinoma. Ginsenoside Rk3 been reported have a plenty biological activities, including anti-apoptotic, anti-anemia, protective effects against acute kidney injury. However, whether ginsenoside can improve NASH not yet. Therefore, purpose this study investigate effect its mechanism action. C57BL/6 mice were treated with different dosages after being established as model. Our results showed that administration significantly improved inflammation, lipid deposition, fibrosis caused by high-fat-high-cholesterol (HFHC) diet CCl4 injection in mice. Notably, was discovered inhibit PI3K/AKT signaling pathway. Additionally, treatment remarkably amended abundance short-chain fatty acids. These changes associated beneficial variations variety composition intestinal microbiota. In conclusion, ameliorates hepatic non-alcoholic inflammation triggers flora, helping reveal host-microbe interactions. The outcomes indicate promising drug candidate for NASH.

Language: Английский

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Lead exposure exacerbates liver injury in high-fat diet-fed mice by disrupting the gut microbiota and related metabolites

Food & Function, Journal Year: 2024, Volume and Issue: 15(6), P. 3060 - 3075

Published: Jan. 1, 2024

Lead (Pb) is a widespread toxic endocrine disruptor that could cause liver damage and gut microbiota dysbiosis.

Language: Английский

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Oat-based postbiotics ameliorate high-sucrose induced liver injury and colitis susceptibility by modulating fatty acids metabolism and gut microbiota

The Journal of Nutritional Biochemistry, Journal Year: 2023, Volume and Issue: 125, P. 109553 - 109553

Published: Dec. 24, 2023

Language: Английский

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Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 1, 2023

Obesity is a health issue worldwide. This study aimed to evaluate the beneficial effects of Pediococcus pentococcus PR-1 on modulating gut microbiota, inflammation and lipid metabolism in high-fat-diet (HFD)-fed zebrafish.Adult zebrafish were fed commercial (C), high fat (H, 25% fat), probiotic (P, 106 CFU/g), or with (HP) diets twice daily for 5 weeks. Gut microbiota analysed using 16S rRNA gene sequencing. Gene expressions intestinal cytokine, TJ protein, liver by quantitative real-time polymerase chain reaction. Biochemical histological analysis also performed.P. pentosaceus reduced body weight BMI, indicating its anti-obesity effect. The sequencing results showed HFD induced distinct structure from C group, which was restored probiotic. P. improved decreasing abundance Ralstonia Aeromonas increased HFD. Moreover, Fusobacteria, Cetobacterium Plesiomonas, decreased HFD-fed zebrafish. reaction suppressed HFD-induced IL-1b IL-6. Levels hepatic TNF-α, IL-1ß, IL-6 Probiotic ameliorated barrier function increasing occludin, Claudin-1, ZO-1. exerted anti-adipogenic activity through regulating SREBP1, FAS LEPTIN. triglyceride, total cholesterol, low density lipoprotein Histological alleviated steatosis injury might be useful as dietary supplement, especially reducing obesity.

Language: Английский

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Effects of plant natural products on metabolic-associated fatty liver disease and the underlying mechanisms: a narrative review with a focus on the modulation of the gut microbiota

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 20, 2024

Metabolic-associated fatty liver disease (MAFLD) is a chronic characterized by the excessive accumulation of fat in hepatocytes. However, due to complex pathogenesis MAFLD, there are no officially approved drugs for treatment. Therefore, an urgent need find safe and effective anti-MAFLD drugs. Recently, relationship between gut microbiota MAFLD has been widely recognized, treating regulating may be new therapeutic strategy. Natural products, especially plant natural have attracted much attention treatment their multiple targets pathways few side effects. Moreover, structure function can influenced exposure products. effects products on through targeting underlying mechanisms poorly understood. Based above information address potential role we systematically summarize action prevention microbiota. This narrative review provides feasible ideas further exploration safer more MAFLD.

Language: Английский

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