Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(7), P. 1772 - 1772
Published: July 7, 2023
Desulfovibrio
(DSV)
are
sulfate-reducing
bacteria
(SRB)
that
ubiquitously
present
in
the
environment
and
as
resident
commensal
within
human
gastrointestinal
tract.
Though
they
minor
residents
of
healthy
gut,
DSV
opportunistic
pathobionts
may
overgrow
setting
various
intestinal
extra-intestinal
diseases.
An
increasing
number
studies
have
demonstrated
a
positive
correlation
between
overgrowth
(bloom)
While
relationship
bloom
disease
pathology
has
not
been
clearly
established,
mounting
evidence
suggests
causal
role
for
these
development.
As
most
predominant
genera
SRB
this
review
summarizes
current
knowledge
regarding
variety
In
study,
we
also
discuss
mechanisms
by
which
contribute
to
pathology.
Reviews in Endocrine and Metabolic Disorders,
Journal Year:
2023,
Volume and Issue:
24(5), P. 839 - 870
Published: April 29, 2023
Obesity
has
reached
epidemic
proportion
worldwide
and
in
all
ages.
Available
evidence
points
to
a
multifactorial
pathogenesis
involving
gene
predisposition
environmental
factors.
Gut
microbiota
plays
critical
role
as
major
interface
between
external
factors,
i.e.,
diet,
lifestyle,
toxic
chemicals,
internal
mechanisms
regulating
energy
metabolic
homeostasis,
fat
production
storage.
A
shift
composition
is
linked
with
overweight
obesity,
pathogenic
bacterial
products
metabolites
(mainly
endocannabinoid-related
mediators,
short-chain
fatty
acids,
bile
catabolites
of
tryptophan,
lipopolysaccharides)
subsequent
alterations
gut
barrier,
altered
insulin
resistance
chronic,
low-grade
inflammation.
Although
animal
studies
point
the
links
an
"obesogenic"
development
different
obesity
phenotypes,
translational
value
these
results
humans
still
limited
by
heterogeneity
among
studies,
high
variation
over
time
lack
robust
longitudinal
adequately
considering
inter-individual
confounders.
Nevertheless,
available
underscores
existence
several
genera
predisposing
or,
conversely,
lean
metabolically
health
phenotype
(e.g.,
Akkermansia
muciniphila,
species
from
Faecalibacterium,
Alistipes,
Roseburia).
Further
using
metagenomics,
transcriptomics,
proteomics,
metabolomics
exact
characterization
confounders
are
needed
this
field.
Results
must
confirm
that
distinct
specific
microbial-derived
represent
effective
precision
interventions
against
long-term.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(34), P. 18971 - 18985
Published: Aug. 15, 2024
Our
previous
study
showed
that
heavy
metal
lead
(Pb)
exposure
exacerbates
high-fat-diet
(HFD)-induced
metabolic
damage
and
significantly
depletes
the
gut
microbiota-derived
metabolite
short-chain
fatty
acid
(SCFA)
levels.
However,
it
remains
unclear
whether
SCFA
is
a
key
involved
in
accelerating
adverse
consequences
after
Pb
exposure.
In
this
study,
we
explored
effects
of
exogenous
supplementation
acetate,
propionate,
butyrate
on
disorder
model
Pb-exposed
HFD
mice.
We
found
three
interventions
attenuated
glycolipid
metabolism
disorders
liver
damage,
with
performing
best
improving
obesity-related
symptoms.
All
promoted
abundance
Toxics,
Journal Year:
2023,
Volume and Issue:
11(8), P. 670 - 670
Published: Aug. 3, 2023
Metabolic
syndrome
(MetS)
is
an
important
public
health
issue
that
affects
millions
of
people
around
the
world
and
growing
to
pandemic-like
proportions.
This
defined
by
World
Health
Organization
(WHO)
as
a
pathologic
condition
characterized
abdominal
obesity,
insulin
resistance,
hypertension,
hyperlipidemia.
Moreover,
etiology
MetS
multifactorial,
involving
many
environmental
factors,
including
toxicant
exposures.
Several
studies
have
associated
with
heavy
metals
exposure,
which
focus
this
review.
Environmental
and/or
occupational
exposure
are
major
risk,
contributing
development
chronic
diseases.
Of
particular
note,
toxic
such
mercury,
lead,
cadmium
may
contribute
altering
oxidative
stress,
IL-6
signaling,
apoptosis,
altered
lipoprotein
metabolism,
fluid
shear
stress
atherosclerosis,
other
mechanisms.
In
review,
we
discuss
known
potential
roles
in
well
targeted
pathways
MetS.
Furthermore,
describe
how
new
approaches
proteomic
transcriptome
analysis,
bioinformatic
tools,
help
bring
about
understanding
involvement
metalloids
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2333 - 2333
Published: Nov. 15, 2024
The
human
gut
is
a
complex
ecosystem
that
supports
billions
of
living
species,
including
bacteria,
viruses,
archaea,
phages,
fungi,
and
unicellular
eukaryotes.
Bacteria
give
genes
enzymes
for
microbial
host-produced
compounds,
establishing
symbiotic
link
between
the
external
environment
host
at
both
systemic
levels.
microbiome,
which
primarily
made
up
commensal
critical
maintaining
healthy
host's
immune
system,
aiding
digestion,
synthesizing
essential
nutrients,
protecting
against
pathogenic
as
well
influencing
endocrine,
neural,
humoral,
immunological
functions
metabolic
pathways.
Qualitative,
quantitative,
and/or
topographic
shifts
can
alter
resulting
in
dysbiosis
dysfunction,
contribute
to
variety
noncommunicable
illnesses,
hypertension,
cardiovascular
disease,
obesity,
diabetes,
inflammatory
bowel
cancer,
irritable
syndrome.
While
most
evidence
date
observational
does
not
establish
direct
causation,
ongoing
clinical
trials
advanced
genomic
techniques
are
steadily
enhancing
our
understanding
these
intricate
interactions.
This
review
will
explore
key
aspects
relationship
microbiota,
eubiosis,
health
highlighting
emerging
strategies
microbiome
engineering
potential
therapeutic
approaches
various
conditions.
