Current Opinion in Biotechnology,
Journal Year:
2024,
Volume and Issue:
87, P. 103112 - 103112
Published: March 22, 2024
Curcumin,
a
potent
plant
polyketide
in
turmeric,
has
gained
recognition
for
its
outstanding
health
benefits,
including
anti-inflammatory,
antioxidant,
and
anticancer
effects.
Classical
turmeric
farming,
which
is
widely
used
to
produce
curcumin,
linked
deforestation,
soil
degradation,
excessive
water
use,
reduced
biodiversity.
In
recent
years,
the
microbial
synthesis
of
curcumin
been
achieved
optimized
through
novel
strategies,
offering
increased
safety,
improved
sustainability,
potential
revolutionize
production.
Here,
we
discuss
breakthroughs
engineering
fermentation
techniques,
as
well
their
capacity
increase
yield,
purity,
cost-effectiveness
The
utilization
systems
not
only
addresses
supply
chain
limitations
but
also
helps
meet
growing
demand
various
industries,
pharmaceuticals,
foods,
cosmetics.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(22)
Published: May 7, 2024
Curcumin
is
a
natural
product
found
in
the
rhizome
of
Curcuma
longa
(L.)
and
other
spp.
As
lipophilic
molecule,
it
has
greater
affinity
for
polar,
non-polar,
alkaline,
or
extremely
acidic
organic
solvents.
Several
studies
indicate
that
curcumin
several
benefits
human
health,
example,
against
degenerative
diseases,
cancer,
infectious
diseases.
To
obtain
quality
with
nutraceutical
properties,
necessary
to
know
its
physicochemical
characteristics
preserve
from
cultivation
until
ingestion
by
human.
However,
low
solubility
leads
absorption;
this
context,
nanotechnological
systems
can
contribute
increase
bioavailability.
This
review
aims
highlight
important
issues
all
stages
goes
through:
aspects
related
extraction
association
nanotechnology.
Although
process
already
well
established,
possible
observe
more
research
focused
on
increasing
yield
being
environmentally
friendly.
Further,
curcumin's
absorption
notable
due
characteristics,
mainly
aqueous
solubility.
nanotechnology
shows
be
promising
an
increasingly
growing
trend
because
use
"Indian
solid
gold"
hope
many
patients.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(22), P. 7963 - 7963
Published: Nov. 17, 2022
Ischemic
stroke
(IS)
is
an
acute
cerebrovascular
disease
caused
by
sudden
arterial
occlusion,
which
characterized
a
high
morbidity,
mortality,
and
disability
rate.
It
one
of
the
most
important
causes
nervous
system
morbidity
mortality
in
world.
In
recent
years,
search
for
new
medicine
treatment
IS
has
become
attractive
research
focus.
Due
to
extremely
limited
time
window
traditional
treatment,
some
side
effects
may
occur,
accompanied
occurrence
adverse
reactions,
frequency
exploration
with
natural
significantly
increased.
Phosphatidylinositol-3-kinase/Protein
kinase
B
(PI3K/Akt)
signaling
pathway
classical
cell
metabolism,
growth,
apoptosis,
other
physiological
activities.
There
considerable
on
that
treats
various
diseases
through
this
pathway.
This
review
focuses
how
medicines
(including
herbs
insects)
regulate
pathophysiological
processes
such
as
inflammation,
oxidative
stress,
autophagy
PI3K/Akt
pathway,
role
it
plays
improving
IS.
We
found
many
kinds
herbal
insect
can
alleviate
damage
Moreover,
prescription
after
their
combination
also
achieve
certain
results.
Therefore,
provides
candidate
category
development
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 7, 2022
Central
nervous
system
(CNS)
disorders
and
diseases
are
expected
to
rise
sharply
in
the
coming
years,
partly
because
of
world’s
aging
population.
Medicines
for
treatment
CNS
have
not
been
successfully
made.
Inadequate
knowledge
about
brain,
pharmacokinetic
dynamic
errors
preclinical
studies,
challenges
with
clinical
trial
design,
complexity
variety
human
brain
illnesses,
variations
species
some
potential
scenarios.
Neurodegenerative
(NDDs)
multifaceted
lack
identifiable
etiological
components,
drugs
developed
treat
them
did
meet
requirements
those
who
anticipated
treatments.
Therefore,
there
is
a
great
demand
safe
effective
natural
therapeutic
adjuvants.
For
NDDs
other
memory-related
problems,
many
herbal
items
used
Ayurvedic
medical
system.
Anxiety,
depression,
Parkinson’s,
Alzheimer’s
(AD),
as
well
plethora
neuropsychiatric
disorders,
may
benefit
from
use
plant
food-derived
chemicals
that
antidepressant
or
antiepileptic
properties.
We
summarized
present
level
products
based
on
topological
evidence,
bioinformatics
analysis,
translational
research
this
review.
also
highlighted
investigation
will
help
us
select
neurological
conditions.
In
review,
we
explored
efficacy
phytoconstituents
against
diseases.
Various
evidence-based
studies
extensive
recent
investigations
included,
which
pharmacologists
reduce
progression
neuronal
disease.
AMB Express,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Nov. 28, 2023
Abstract
Brain-Derived
Neurotrophic
Factor
(
BDNF
)
is
a
neurotrophin
gene
family
that
encodes
proteins
vital
for
the
growth,
maintenance,
and
survival
of
neurons
in
nervous
system.
The
study
aimed
to
screen
natural
compounds
against
variant
(V66M),
which
affects
memory,
cognition,
mood
regulation.
(V66M)
as
target
structure
was
selected,
Vitamin
D,
Curcumin,
C,
Quercetin
ligands
structures
were
taken
from
PubChem
database.
Multiple
tools
like
AUTODOCK
VINA,
BIOVIA
discovery
studio,
PyMOL,
CB-dock,
IMOD
server,
Swiss
ADEMT,
predict
used
analyze
binding
energy,
interaction,
stability,
toxicity,
visualize
-ligand
complexes.
Compounds
D3,
with
energies
values
−
5.5,
6.1,
4.5,
6.7
kj/mol,
respectively,
selected.
bind
active
sites
via
hydrophobic
bonds,
hydrogen
electrostatic
interactions.
Furthermore,
ADMET
analysis
revealed
they
exhibited
sound
pharmacokinetic
toxicity
profiles.
In
addition,
an
MD
simulation
showed
most
ligand
bound
favorably
dynamically
protein,
protein–ligand
complex
stability
determined.
finding
this
research
could
provide
excellent
platform
discovering
rationalizing
novel
drugs
stress
related
(V66M).
Docking,
preclinical
drug
testing
results
suggest
more
potent
inhibitor
forming
structurally
stable
complex.
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(3), P. 512 - 518
Published: July 20, 2023
Abstract
CD36
is
a
highly
glycosylated
integral
membrane
protein
that
belongs
to
the
scavenger
receptor
class
B
family
and
regulates
pathological
progress
of
metabolic
diseases.
was
recently
found
be
widely
expressed
in
various
cell
types
nervous
system,
including
endothelial
cells,
pericytes,
astrocytes,
microglia.
mediates
number
regulatory
processes,
such
as
dysfunction,
oxidative
stress,
mitochondrial
inflammatory
responses,
which
are
involved
many
central
system
diseases,
stroke,
Alzheimer’s
disease,
Parkinson’s
spinal
cord
injury.
antagonists
can
suppress
expression
or
prevent
binding
its
ligand,
thereby
achieving
inhibition
CD36-mediated
pathways
functions.
Here,
we
reviewed
mechanisms
action
antagonists,
Salvianolic
acid
B,
tanshinone
IIA,
curcumin,
sulfosuccinimidyl
oleate,
antioxidants,
small-molecule
compounds.
Moreover,
predicted
structures
sites
between
antagonists.
These
provide
targets
for
more
efficient
safer
treatment
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 2869 - 2881
Published: July 1, 2024
Parkinson's
disease
(PD)
is
the
most
prevalent
movement
disorder.
Curcumin,
a
polyphenol
with
hydrophobic
properties,
has
been
proved
against
Parkinson.
Our
previous
study
suggested
that
curcumin's
effectiveness
in
treating
may
be
linked
to
gut-brain
axis,
although
specific
mechanism
by
which
curcumin
exerts
neuroprotective
effects
brain
remains
unknown.
