Nutrients,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1298 - 1298
Published: April 26, 2024
Natural
products
from
mushrooms,
plants,
microalgae,
and
cyanobacteria
have
been
intensively
explored
studied
for
their
preventive
or
therapeutic
potential.
Among
age-related
pathologies,
neurodegenerative
diseases
(such
as
Alzheimer’s
Parkinson’s
diseases)
represent
a
worldwide
health
social
problem.
Since
several
pathological
mechanisms
are
associated
with
neurodegeneration,
promising
strategies
against
aimed
to
target
multiple
processes.
These
approaches
usually
avoid
premature
cell
death
the
loss
of
function
damaged
neurons.
This
review
focuses
attention
on
potential
compounds
derived
natural
sources,
which
could
be
exploited
neuroprotective
effect.
Curcumin,
resveratrol,
ergothioneine,
phycocyanin
presented
examples
successful
approaches,
special
focus
possible
improve
delivery
brain.
Processes,
Journal Year:
2024,
Volume and Issue:
12(7), P. 1456 - 1456
Published: July 12, 2024
Alzheimer’s
disease,
characterized
by
a
decline
in
cognitive
functions,
is
frequently
associated
with
decreased
levels
of
acetylcholine
due
to
the
overactivity
acetylcholinesterase
(AChE).
Inhibiting
AChE
has
been
key
therapeutic
strategy
treating
yet
search
for
effective
inhibitors,
particularly
from
natural
sources,
continues
their
potential
fewer
side
effects.
In
this
context,
three
new
alkaloids—oleracone
L,
portulacatone
B,
and
portulacatal—extracted
Portulaca
oleracea
L.,
have
recently
shown
promising
anticholinesterase
activity
vitro.
However,
no
experimental
or
computational
studies
explored
binding
potential.
This
study
represents
first
comprehensive
silico
analysis
these
compounds,
employing
ADME
prediction,
molecular
docking,
dynamics
simulations,
MM-PBSA
calculations
assess
The
drug-likeness
was
evaluated
based
on
Lipinski,
Pfizer,
Golden
Triangle,
GSK
rules,
all
alkaloids
meeting
criteria.
profiles
suggested
that
can
effectively
cross
blood–brain
barrier,
critical
requirement
treatment.
Molecular
docking
revealed
oleracone
L
had
highest
affinity
(−10.75
kcal/mol)
towards
AChE,
followed
portulacatal
demonstrating
significant
interactions
crucial
enzyme
residues.
simulations
over
200
ns
confirmed
stability
interactions,
RMSD
values
below
2
Å
complexes,
indicating
stable
throughout
simulation
period.
RMSF
radius
gyration
analyses
further
corroborated
minimal
impact
enzyme’s
overall
flexibility
compactness.
Moreover,
provided
additional
support
efficacy,
showing
most
favorable
energy,
could
be
superior
inhibitor,
potentially
its
stronger
more
consistent
hydrogen
bonding
electrostatic
compared
other
studied
alkaloids.
These
findings
highlight
efficiency
viability
as
suggesting
they
candidates
disease
underscores
importance
validation
through
vitro
vivo
experiments
confirm
predictions.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1058 - 1058
Published: March 24, 2023
In
the
past,
wounds
were
treated
with
natural
materials,
but
modern
wound
dressings
include
functional
elements
to
expedite
process
of
healing
and
improve
skin
recovery.
Due
their
exceptional
properties,
nanofibrous
are
now
most
cutting-edge
desirable
option.
Similar
in
structure
skin’s
own
extracellular
matrix
(ECM),
these
can
promote
tissue
regeneration,
fluid
transportation,
air
ductility
for
cellular
proliferation
regeneration
owing
nanostructured
fibrous
meshes
or
scaffolds.
Many
academic
search
engines
databases,
such
as
Google
Scholar,
PubMed,
Sciencedirect,
used
conduct
a
comprehensive
evaluation
literature
purposes
this
investigation.
Using
term
“nanofibrous
meshes”
keyword,
paper
focuses
on
importance
phytoconstituents.
This
review
article
summarizes
recent
developments
conclusions
from
studies
bioactive
infused
medicinal
plants.
Several
wound-healing
methods,
wound-dressing
components
derived
plants
also
discussed.
The
global
herbal
medicine
industry
is
rapidly
growing
due
to
increasing
consumer
demand
for
natural
and
alternative
healthcare
options.
Herbal
medicines
are
valued
their
antioxidant
anti-inflammatory
properties,
making
them
popular
choices
addressing
health-related
issues
promoting
overall
well-being.
market
includes
a
variety
of
products,
such
as
pharmaceuticals,
functional
foods,
dietary
supplements,
beauty
all
which
sought
after
nontoxic
nature,
fewer
side
effects,
affordability.
Despite
the
promising
opportunities,
faces
challenges
related
safety,
efficacy,
regulatory
considerations.
To
succeed
in
this
market,
players
must
focus
on
educating
consumers,
investing
research,
providing
evidence-based
products
that
meet
needs
health-conscious
individuals.
Quality
control
standardization
crucial
maintaining
consistent
quality
differentiating
competitive
market.
Collaborating
with
professionals
can
help
integrate
into
mainstream
healthcare,
gaining
acceptance
through
recommendations
prescriptions.
Personalization
customization
important
attract
consumers
seeking
targeted
solutions
specific
lifestyle-related
health
issues.
Leveraging
e-commerce
digital
marketing
broaden
reach
globally.
Sustainability
ethical
sourcing
resonate
environmentally
conscious
enhancing
appeal
products.
Exploring
international
markets,
especially
developing
countries
deep-rooted
culture,
presents
significant
growth
opportunities.
regulations,
has
vast
potential
solutions,
prevalence
lifestyle
diseases,
awareness,
research
validation,
integration
conventional
healthcare.
By
adhering
practices,
control,
shape
future
wellness,
contributing
healthier
more
sustainable
approach
Critical Reviews in Food Science and Nutrition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 37
Published: May 24, 2024
Neurodegenerative
diseases
encompass
a
wide
range
of
debilitating
and
incurable
brain
disorders
characterized
by
the
progressive
deterioration
nervous
system's
structure
function.
Isoflavones,
which
are
naturally
occurring
polyphenolic
phytochemicals,
have
been
found
to
regulate
various
cellular
signaling
pathways
associated
with
system.
The
main
objective
this
comprehensive
review
is
explore
neuroprotective
effects
isoflavones,
elucidate
underlying
mechanisms,
assess
their
potential
for
treating
neurodegenerative
disorders.
Relevant
data
regarding
isoflavones
impact
on
were
gathered
from
multiple
library
databases
electronic
sources,
including
PubMed,
Google
Scholar,
Web
Science,
Science
Direct.
Numerous
genistein,
daidzein,
biochanin
A,
formononetin,
exhibited
potent
properties
against
diseases.
These
compounds
modulate
neurotransmitters,
in
turn
contributes
ability
protect
neurodegeneration.
Both
vitro
vivo
experimental
studies
provided
evidence
neuroprotection
involve
interactions
estrogenic
receptors,
antioxidant
effects,
anti-inflammatory
properties,
anti-apoptotic
activity,
modulation
neural
plasticity.
This
aims
provide
current
insights
into
characteristics
shed
light
therapeutic
applications
future
clinical
scenarios.
Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
32(10), P. 1233 - 1246
Published: Aug. 12, 2024
Nanotechnology
has
significantly
impacted
human
life,
particularly
in
overcoming
the
limitations
associated
with
neurodegenerative
diseases
(NDs).
Various
nanostructures
and
vehicle
systems,
such
as
polymer
nanoparticles,
carbon
nanotubes
(CNTs),
nanoliposomes,
nano-micelles,
lipid
lactoferrin,
polybutylcyanoacrylate,
poly
lactic-co-glycolic
acid,
have
been
shown
to
enhance
drug
efficacy,
reduce
side
effects,
improve
pharmacokinetics.
NDs
affect
millions
worldwide
are
challenging
treat
due
blood-brain
barrier
(BBB),
which
hinders
delivery
central
nervous
system
(CNS).
Research
suggests
that
natural
ingredients
can
be
formulated
into
offering
a
promising
approach
for
ND
treatment.
This
review
examines
advantages
disadvantages
of
herbal-based
nanoformulations,
highlighting
their
potential
effectiveness
when
used
alone
or
combination
other
medications.
Herbal
nanoparticles
provide
benefits
over
synthetic
ones
biocompatibility,
reduced
toxicity,
synergistic
effects.
The
study's
findings
applied
develop
more
efficient
improving
treatment
by
enhancing
penetration
across
BBB
targeting
affected
CNS
areas
precisely.
