Association between heavy metal exposures and the prevalence of pelvic inflammatory disease: a cross-sectional study from the National Health and Nutrition Examination Survey 2013–2018 DOI

Panwei Hu,

Hui Hu,

Xiaomei Jiang

et al.

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(52), P. 112433 - 112444

Published: Oct. 13, 2023

Language: Английский

Effects of Various Heavy Metal Exposures on Insulin Resistance in Non-diabetic Populations: Interpretability Analysis from Machine Learning Modeling Perspective DOI
Jun Liu, Xingyu Li, Peng Zhu

et al.

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: 202(12), P. 5438 - 5452

Published: Feb. 26, 2024

Language: Английский

Citations

4
Impacts of elevated lead levels on oxidative stress, hemodynamic, and biochemical indicators in goats DOI Creative Commons
Magdy Elgioushy,

Seif E. Salem,

Abdullah M. Alsharif

et al.

Italian Journal of Animal Science, Journal Year: 2025, Volume and Issue: 24(1), P. 813 - 826

Published: March 18, 2025

Language: Английский

Citations

0
Associations of endocrine-disrupting chemicals mixtures with serum lipid and glucose metabolism among overweight/obese and normal-weight children: A panel study DOI
Yuanyuan Zhang, Biao Zhang, Huihua Yang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118077 - 118077

Published: March 20, 2025

Language: Английский

Citations

0
Assessment of carbohydrate and lipid metabolism in workers of lead-acid batteries recycling plant DOI
Kuz'mina Lp, А.Г. Хотулева, M. M. Kolyaskina

et al.

Russian Journal of Occupational Health and Industrial Ecology, Journal Year: 2025, Volume and Issue: 65(3), P. 142 - 149

Published: April 7, 2025

Introduction. Lead is one of the proven risk factors for developing cardiovascular diseases, which determined by its effect on vascular tone, lipid and carbohydrate metabolism, as well activity inflammatory process, therefore monitoring metabolic parameters an important component preventive measures workers in contact with lead compounds. The study aims to analyze changes metabolism employees a lead-acid battery processing plant select informative markers assessing risk. Materials methods. main group consisted 62 men working at recycling 8 (4; 10) years experience. control 30 who worked outside harmful industrial factors. laboratory examination included determination blood levels, ALA urine, (glucose, insulin) (cholesterol (HC), high-density lipoprotein (HDL) cholesterol, low-density (LDL) triglycerides, apolipoproteins A1 B, (a)) metabolism. Non-HDL atherogenicity index (IA), apo B/apo A1, TG/HDL (MI), HOMA-IR were calculated. Results. Compared group, individuals showed lower levels HDL higher insulin, HOMA-IR, MI. Correlations work experience revealed absence age dependence cholesterol (r=–0.35, p=0.006), IA (r=0.258, p=0.043), (r=–0.313, p=0.013), (r=0.287, p=0.024), MI (r=0.262, p=0.04). It has been shown that least 10 service, are lower, IA, TG/HDL-C, compared less There average degree relationship between indirect insulin resistance (r=0.525, p<0.001) (r=0.568, p<0.001). Limitations. limited sample surveyed single facility. Conclusion. influence exposure production development disorders shown, determines importance studying additional (HDL triglycerides) these enterprises objectify assessment processes. Ethics. was conducted compliance Ethical standards conducting medical research involving humans accordance requirements Helsinki Declaration World Medical Association. approved conclusion local Ethics Committee Izmerov Research Institute Occupational Health (protocol meeting No. 5 dated 08/02/2023).

Language: Английский

Citations

0
Metabolomic and microbiome profiling reveals the anti-Pb effect of Lactiplantibacillus plantarum DOI
Yuhang Gao, Leilei Yu, Hui Duan

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 58, P. 103740 - 103740

Published: Feb. 9, 2024

Language: Английский

Citations

3
Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis DOI Creative Commons

Meiqi Ren,

Liantong Wang,

Liqin Wen

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 29, 2023

This study aimed to evaluate the association between blood heavy metal (zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd)) concentrations spontaneous abortion (SA) recurrent pregnancy loss (RPL) explore possible endocrine dysfunction associated with it.A literature search was performed in PubMed, Embase, Cochrane Library, Web of Science databases up April 2023. The overall effects were expressed as standard mean difference (SMD). Subgroup analysis according type (SA or RPL). Stata 16.0 utilized for data analysis.Based on integrated findings, women showed significantly lower Zn (SMD = -1.05, 95% CI: -1.74 -0.36, p 0.003) Cu -1.42, -1.97 -0.87, <0.001) higher Pb 1.47, 0.89-2.05, Cd 1.15, 0.45-1.85, 0.001) than normal pregnant women. that deficiency exposure (p <0.05) RPL, whereas SA.Zn deficiencies abortion. Endocrine dysfunction, such insulin resistance, vitamin D insufficiency, abnormal thyroid sex hormone concentrations, is thought be involved metal-related

Language: Английский

Citations

8
Combined exposure to deoxynivalenol facilitates lipid metabolism disorder in high-fat-diet-induced obesity mice DOI Creative Commons
Jing Jin,

Bingxin Huangfu,

Fuguo Xing

et al.

Environment International, Journal Year: 2023, Volume and Issue: 182, P. 108345 - 108345

Published: Nov. 22, 2023

Deoxynivalenol (DON) is a trichothecene toxin that mainly produced by strains of Fusarium spp. DON contamination widely distributed and global food safety threat. Existing studies have expounded its harmful effects on growth inhibition, endocrine disruption, immune function impairment, reproductive toxicity. In energy metabolism, suppresses appetite, reduces body weight, triggers lipid oxidation, negatively affects cholesterol fatty acid homeostasis. this study, high-fat diet (HFD) induced obese C57BL/6J mice were orally treated with 0.1 mg/kg bw/d 1.0 for 4 weeks. The metabolism the molecular mechanisms explored. data showed although reduced weight fat mass in HFD mice, it significantly increased their serum triglyceride concentrations, disturbance metabolites, impaired glucose, resulted insulin intolerance mice. addition, transcriptional expression changes genes liver epididymis (EP) adipose indicate DON-mediated increase triglycerides caused lipoprotein lipase (LPL) inhibition EP adipose. Furthermore, down-regulates LPL through PPARγ signaling pathway These results are further confirmed lipidomics analysis. conclusion, acts white to inhibit LPL, mediate disturb homeostasis risk cardiovascular disease. This study reveals interference mechanism provides theoretical basis toxic effect individuals.

Language: Английский

Citations

8
Co-exposure to lead and high-fat diet aggravates systemic inflammation in mice by altering gut microbiota and the LPS/TLR4 Pathway DOI
Nana Wang, Changhao Li,

Xue Gao

et al.

Metallomics, Journal Year: 2024, Volume and Issue: 16(5)

Published: April 23, 2024

This study reports the toxicity of Pb exposure on systemic inflammation in high-fat-diet (HFD) mice and potential mechanisms. Results indicated that exacerbated intestinal barrier damage increased serum levels lipopolysaccharide (LPS) diamine oxidase HFD mice. Elevated LPS activates colonic ileal LPS-TLR4 inflammatory signaling pathway further induces hepatic adipose expression. The 16S rRNA gene sequencing results showed promoted abundance potentially harmful LPS-producing bacteria such as Coriobacteriaceae_UCG-002, Alloprevotella, Oscillibacter intestines mice, their was positively correlated with levels. Additionally, inhibited beneficial Akkermansia, resulting lower metabolite short-chain fatty acids (SCFAs). Meanwhile, adenosine 5'-monophosphate-activated protein kinase signaling-mediated lipid metabolism pathways, promoting accumulation. above suggest exacerbates disorders by altering gut microbiota, barrier, mediation metabolites SCFAs. Our provides novel mechanisms human health related to Pb-induced metabolic offers new evidence for a comprehensive assessment risk.

Language: Английский

Citations

2
Mitigating lead-induced osteoporosis: The role of butyrate in gut-bone axis restoration DOI Creative Commons

Yuqiu Ge,

Zhongtang Jia,

Shiting Zhao

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116943 - 116943

Published: Aug. 30, 2024

Lead (Pb) is an environmentally widespread bone toxic pollutant, contributes to the development of osteoporosis. Butyric acid, mainly produced by fermentation indigestible dietary fiber gut microbiota, plays a pivotal role in maintenance homeostasis. However, effects butyric acids on Pb induced osteoporosis have not yet been elucidated. In this study, our results showed that exposure was negatively related abundance Pb-exposed population and mice. caused microbiota disorders, resulting decline acid-producing bacteria, such as Butyrivibrio_crossotus, Clostridium_sp._JN9, butyrate-producing enzymes through acetyl-CoA pathway. Moreover, from NHANES data suggested intake butyrate associated with reduced risk lead-burdened populations, particularly among men or participants aged 18–60 years. addition, supplementation mice chronic improved microarchitectures, repaired intestinal damage, upregulated proportion Treg cells. Taken together, these demonstrated disturbs gut-bone axis, which can be restored acid supplement. Our suggest possible therapeutic strategy for lead-induced toxicity.

Language: Английский

Citations

2
Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice DOI

Nana Wang,

Xue Gao,

Yuan Huo

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2023, Volume and Issue: 104(5), P. 3057 - 3068

Published: Dec. 7, 2023

Lead (Pb) is an ancient toxic metal and still a major public health issue. Our previous study found that Pb exposure promotes metabolic disorders in obese mice, but the molecular mechanisms remain unclear. The present explored effects of on glucose homeostasis mice fed normal diet (ND) high-fat (HFD) from perspective gut microbiota.

Language: Английский

Citations

6