Fruit waste: a current perspective for the sustainable production of pharmacological, nutraceutical, and bioactive resources

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 24, 2023

Fruits are crucial components of a balanced diet and good source natural antioxidants, that have proven efficacy in various chronic illnesses. Various kinds waste generated from fruit industries considered global concern. By utilizing this waste, the international goal “zero waste” can be achieved by sustainable utilization these materials as rich secondary metabolites. Moreover, to overcome burden, research focused on recovering bioactive compounds obtaining new strategy combat certain diseases. The separation high-value substances including phytochemicals, dietary fibers, polysaccharides which then used functional ingredients for long-term health benefits. Several novel extraction technologies like ultrasound-assisted (UAE), pressurized liquid (PLE), supercritical fluid (SFE) could provide an alternative approach successful valuable bioactives their nutraceuticals, therapeutics, value-added products. Most waste-derived metabolites comprise polyphenols, been reported anti-inflammatory, insulin resistance-treating, cardiovascular disease-maintaining, probiotics-enhancing, or even anti-microbial anti-viral capabilities. This review summarizes current knowledge by-products pharmacological, biological, probiotic applications highlights several methods identifying efficacious wastes.

Language: Английский

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Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: March 28, 2025

Curcumin, a natural active compound derived from plants, is widely used as pigment across the globe. Research has demonstrated that curcumin possesses neuroprotective properties in spinal cord injuries (SCIs); however, its specific mechanisms of action remain unclear. This study aimed to elucidate potential underlying curcumin's therapeutic effects SCI. We screened targets treatment injury using network pharmacology variety public databases. The interaction between and target was analyzed through bioinformatics analysis, molecular docking, dynamics simulation. Finally, prediction results were verified by simulating oxygen-glucose deprivation (OGD) PC12 cells. Initial screening indicated 13 core involved mitigating Curcumin may regulate HIF pathway, immune cells, inflammation, oxidative stress, other processes. Matrix metalloproteinase-9 (MMP9), tumor necrosis factor (TNF), interleukin-1β (IL-1β), signal transducer activator transcription 3 (STAT3), caspase (CASP3) identified key SCI regulation. Molecular docking exhibited favorable affinity with targets, MMP9 showing highest binding (-8.76 kcal/mol). Further studies confirmed stably binds MMP9, site located at residues 220-225. Cell counting kit-8 (CCK8) assay showed exerted good effect. Western blot inhibited expression protein but had no significant effect on TNF-α. exerts multiple pathways. Its involve inhibition prevention apoptosis ferroptosis, promotion neuronal repair. be mediating protective against These findings provide scientific evidence for further research development drugs.

Language: Английский

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Associations of non-essential metal/metalloids and their mixture with liver function in Chinese older adults: the mediating roles of lipid profiles

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126207 - 126207

Published: April 1, 2025

Language: Английский

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Inhalation of subway fine particles induces murine extrapulmonary organs damage

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 878, P. 163181 - 163181

Published: March 29, 2023

Language: Английский

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Anti-ischemic drug trimetazidine blocks mercury nephrotoxicity by suppressing renal redox imbalance, inflammatory stress and caspase-dependent apoptosis in rats

Drug and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 47(5), P. 674 - 681

Published: Aug. 2, 2023

Trimetazidine (TMZ) is a promising emerging therapeutic piperazine derivative for renal pathologies. However, the nephroprotective mechanism of TMZ against heavy metal-induced toxicity unknown. This study, therefore, aimed to explore whether could mitigate mercury-induced nephrotoxicity in rats. Rats were injected (3 mg/kg bw) and/or mercury chloride (HgCl

Language: Английский

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Anti-inflammatory effects of banana (Musa balbisiana) peel extract on acne vulgaris: In vivo and in silico study

Journal of Taibah University Medical Sciences, Journal Year: 2023, Volume and Issue: 18(6), P. 1586 - 1598

Published: July 29, 2023

Acne vulgaris (AV) is a common problem with relatively high incidence rate among Asian people. The potential antimicrobial and anti-inflammatory properties of banana peels have been demonstrated in previous studies but not studied cases AV. Therefore, this study was aimed at investigating the protective effects (Musa balbisiana) peel extract (MBPE) against AV.Thirty rats were divided into five groups (n = 6 per group): an AV group, group treated 0.15% MBPE, administered 0.30% 0.60% clindamycin (the standard drug treatment). We assessed nodule size, bacterial count, histopathology, cytokine levels (IL-1α, IFN-γ, tumor necrosis factor (TNF)-α, IL-8). Enzyme linked immunoassays used to measure levels. In addition, we performed molecular docking determine interactions between phytochemicals (trigonelline, vanillin, ferulic acid, isovanillic rutin, salsolinol) via Toll-like receptor 2 (TLR2) nuclear factor-kappa B (NF-κB) pathways.All MBPE treatment groups, compared showed suppression both growth proinflammatory production, as well resolved tissue inflammation. size significantly suppressed receiving two highest doses group. However, pharmacological action remained inferior that clindamycin. Docking rutin phytocompound most negative interaction energy TLR2 or NF-κB.Our results indicated has AV, by suppressing formation, inhibiting growth, decreasing production.حب الشباب الشائع مشكلة شائعة، مع معدل حدوث مرتفع نسبيا بين الآسيويين. بالمناسبة، تم إثبات الخصائص المحتملة المضادة للميكروبات والمضادة للالتهابات لقشور الموز في دراسات سابقة؛ ومع ذلك، لم يتم دراستها حالة حب الشباب. هدفت الدراسة الحالية إلى معرفة التأثيرات الوقائية لمستخلص قشر (موسى بالبسيانا) بسبب الشباب.تم تقسيم ثلاثين جرذا خمس مجموعات (عدد فئران كل مجموعة): مجموعة الشباب، المعالجة بـ 0.15 ٪ بالبيسيانا) ، بنسبة 0.30 بالبيسيانا)، 0.60 وحب المجموعة التي إعطاؤها الكليندامايسين كدواء قياسي. قمنا بتقييم حجم العقيدات وعدد البكتيريا وعلم الأنسجة ومستويات السيتوكين (انترليوكن-1، وانتر فيرون جاما، وعامل نخر العظم-ألفا، انترليوكن-8). استخدام المقايسات المناعية المرتبطة بالإنزيم لقياس مستويات السيتوكين. بالإضافة أجرينا الالتحام الجزيئي لتحديد التفاعلات المواد الكيميائية النباتية (تريغونيلين، الفانيلين، حمض الفيروليك، الأيزوفانيليك، الروتين، والسالسولينول) عبر مسارات المستقبل الشبيه بالتول-2 والعامل النووي – كابا ب.أدت جميع جرعات تثبيط نمو وإنتاج السيتوكينات المنشطة مقارنة بمجموعة علاج التهاب الأنسجة. قمع العقدة بشكل معنوي بأعلى جرعتين من يظل تأثيره الدوائي أدنى تأثير الكليندامايسين. أظهرت أن المركب النباتي ذو الطاقة التفاعلية الأكثر سلبية ب كان روتيني.تشير هذه النتائج مستخلص يعمل كعامل مضاد ضد الشائع، عن طريق تكوينات العقيدات، وتثبيط البكتيريا، وتقليل إنتاج المسببة للالتهابات.

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Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 895, P. 165181 - 165181

Published: June 28, 2023

Language: Английский

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Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino rats

Current Research in Toxicology, Journal Year: 2022, Volume and Issue: 4, P. 100098 - 100098

Published: Dec. 22, 2022

The thyroid is vital for the proper functioning of female reproductive system since it regulates metabolism and development ovary. This an evaluation essential trace elements ETE on heavy metals mixture HMM mediated oxido-inflammatory effects in ovary albino rats. Five groups (5 rats /group) were treated as follows 60 days: Group 1: Deionized water only; 2: (Pb, Hg, Mn Al); 3: + ZnCl2, 0.80 mg/kg; 4: Na2SeO3, 1.50 5: mg/kg combined. On day animals euthanized, harvested used for, MDA, NO, antioxidants, TNF-α, IL-6, HMOX-1, Caspase-3, NF-KB, NRF2, HM histopathology. There was significant bioaccumulation Pb, Al, Hg MN; elevated IL-6 MDA caspase-3 NFKB HMOX-1 with decrease antioxidants only group comparison to control. Co-treatment reversed most these effects. may ameliorate -induced ovarian thyrotoxicity by blunting activities.

Language: Английский

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Bioactivities and Applications of Fruit Byproducts and Their Phytochemicals: A Mini Review

Food Reviews International, Journal Year: 2024, Volume and Issue: 40(10), P. 3964 - 4004

Published: Aug. 8, 2024

The growing demand for essential nutrients provided by fruits has led to an increase in processed fruit products. However, this processing generates a significant amount of byproducts. Due lack awareness about their nutritional and health benefits, these byproducts are often treated as waste, negatively impacting the environment. To address this, review focuses on potential effects industrial reusability bioactive compounds from commonly consumed United States including apples, bananas, citrus, watermelon. reviewed studies showed that by-products, peels, seeds, pomace, skin, rinds, rich sources at higher concentrations than flesh, offering benefits antioxidant, antibacterial, antidiabetic, anti-obesity, immunomodulatory, anticancer, anti-inflammatory properties. Incorporation foods improved physicochemical nutrition properties they dietary fiber polyphenols. While many show promising results vitro animal models, further research is needed understand effectiveness humans sustainable food innovation.

Language: Английский

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2-ethylhexyl diphenyl phosphate exposure induces duodenal inflammatory injury through oxidative stress in chickens

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116784 - 116784

Published: July 31, 2024

2-ethylhexyl diphenyl phosphate (EHDPHP) is a widely used organophosphorus flame retardant and plasticizer, which commonly found in the environment. EHDPHP not only potentially harms environment but also causes different degrees of damage to organism. In this study, duodenum chicks was selected as potential toxic target organ explore mechanism duodenal injury induced by exposure. Ninety one-day-old healthy male were randomly divided into C1(control group), C2(solvent control L(800 mg/kg), M(1600 H(3200 mg/kg) according doses after one week environmental adaptation. The given continuous gavage for 14 d, 28 42 d. It that constant exposure caused an increase MDA content, decrease P-gp, SOD, GSH-Px activities, mucosal immune factor (sIgA, GSH-Px). expression sIgM link proteins (CLDN, OCLN, ZO-1, JAM) decreased, inflammatory protein (NF-κB, COX2) tissues up-regulated. results showed could cause oxidative stress, inflammation, barrier chicks, provided basis studying poultry.

Language: Английский

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