Neurotoxic Cocktail of Low-Dose Metals: Investigating the Impact of Environmentally Relevant Lead, Cadmium, Mercury and Arsenic Mixture in Vivo and in Silico DOI
Katarina Živančević, Katarina Baralić, Dragana Vukelić

et al.

Published: Jan. 1, 2023

The assessment of neurotoxic effects lead, cadmium, mercury, and arsenic mixture (MIX) administered at environmentally relevant low doses, was conducted using both in vivo silico approaches. A subacute study on a rat model (number animals per group: 5), consisting control five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 5). Behavioral tests were the last day, brain tissue examined for oxidative stress, pathohistological changes acetylcholinesterase (AChE) activity. Low did not affect spontaneous locomotor activity (SLA), but highest dose showed tendency memory impairment (NORT). Dose-response analysis indicated that even concentrations toxic metals can cause damage (Benchmark methodology). 2 imbalance most narrow BMDI detected superoxide dismutase falling within range 1e-06 3.18e-05 mg As/kg b.w./day. Pathohistological alterations severe 5 group. In (Comparative Toxicogenomics Database) predicted reduction AChE by MIX. This prediction subsequently validated an experiment, demonstrating dose-dependent decrease. current highlights vulnerability mature minimal amounts investigated metal mixture, particularly context early onset cholinergic susceptibility higher doses.

Language: Английский

Early prediction of cognitive impairment in adults aged 20 years and older using Machine learning and biomarkers of heavy metal exposure DOI Creative Commons
Seyed Ali Nabavi, Farima Safari,

Mohammad Kashkooli

et al.

Current Research in Toxicology, Journal Year: 2024, Volume and Issue: 7, P. 100198 - 100198

Published: Jan. 1, 2024

Language: Английский

Citations

1
Maternal Iron Deficiency and Environmental Lead (Pb) Exposure Alter the Predictive Value of Blood Pb Levels on Brain Pb Burden in the Offspring in a Dietary Mouse Model: An Important Consideration for Cumulative Risk in Development DOI Open Access
Janine Cubello, Derick R. Peterson, Lu Wang

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4101 - 4101

Published: Sept. 22, 2023

Maternal iron deficiency (ID) and environmental lead (Pb) exposure are co-occurring insults that both affect the neurodevelopment of offspring. Few studies have investigated how ID affects brain-region-specific Pb accumulations using human-relevant concentrations. Furthermore, these exposures impact blood brain Fe levels remains unclear. Importantly, we also wanted to determine whether use as a surrogate for burden is affected by underlying status. We exposed virgin Swiss Webster female mice one six conditions differing diet water concentration (0 ppm, 19 or 50 ppm acetate) used Inductively Coupled Plasma Mass Spectrometry measure maternal offspring circulating, stored, levels. found rendered iron-deficient anemic led region-specific depletion was exacerbated in dose-specific manner. The postnatal anemia cortical hippocampal accumulation. Interestingly, BPb only correlated with pups but not IN conclude significantly increases alone insufficient clinical make extrapolations on burden.

Language: Английский

Citations

2
A single-cell transcriptomic landscape of cadmium-hindered brain development in mice DOI Creative Commons

Qinlong Ma,

Zhiqi Yang, Chuanyan Yang

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Aug. 15, 2024

The effects of neurotoxicant cadmium (Cd) exposure on brain development have not been well elucidated. To investigate this, we herein subjected pregnant mice to low-dose Cd throughout gestation. Using single-cell RNA sequencing (scRNA-seq), explored the cellular responses in embryonic exposure, and identified 18 distinct cell subpopulations that exhibited varied Cd. Typically, impeded maturation cells brain, especially progenitor such as neural (NPCs) oligodendrocyte (OPCs). It also caused significant subpopulation shifts almost all types brain. Additionally, reduced dendritic sophistication cortical neurons offspring. Importantly, these changes led aberrant Ca2+ activity cortex behavior mature These data contribute our understanding mechanisms highlight importance controlling environmental at population level. Prenatal induced shifts, which lead activities behavioral dysfunction

Language: Английский

Citations

0
Trophic Stoichiometry of Macroelements and Metals in a Terrestrial Food Web DOI
Junjie Cai, Ying Zeng, Yujing Zhu

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 124993 - 124993

Published: Sept. 1, 2024

Language: Английский

Citations

0
Contaminated Waters: A Comprehensive Review of Heavy Metal Pollution in Marine Fish and Its Health Risks DOI Creative Commons
Titin Kurniasih, Novita Panigoro,

Husain Panigoro

et al.

BIO Web of Conferences, Journal Year: 2024, Volume and Issue: 147, P. 01027 - 01027

Published: Jan. 1, 2024

Marine fish are crucial for the global food supply, providing essential nutrients to millions of people throughout world. However, presence high levels heavy metals in marine has become a significant risk both human health and sustainability fishing industry. This article is provide concise overview recent scientific studies on products potential consequences health. The examination encompasses range frequently encountered metals, along with factors that affect pollution. review also explores geographical distribution contaminated fish, pinpointing areas contamination necessitate focused attention. study utilizes an comprehensive literature search technique by searching databases inclusion criteria comprising relevant recently published studies. extracted data comprises information degrees contamination, species affected, arise from consuming infected fish. emphasizes necessity further research address existing knowledge gaps develop more efficient technologies policies managing metal environments.

Language: Английский

Citations

0
Lipoic acid abates testis lead accumulation, sperm-endocrine deficits, testicular oxidative inflammation and apoptosis and modulates gene expression of Bax and Bcl-2 in rats DOI Creative Commons
Ademola C. Famurewa, Hamida Hamdi,

Azza Sedky

et al.

Scientific African, Journal Year: 2023, Volume and Issue: 21, P. e01842 - e01842

Published: Aug. 5, 2023

The current study explored whether ALA could prevent testis Pb accumulation and Pb-induced oxidative testicular toxicity in rats. Adult male rats were randomly divided administered (25 mg/kg/day) and/or (Pb acetate, 20 Control group, + group for 4 weeks consecutively. exposure significantly increased the testes blood of Pb-exposed compared to control. caused marked deficits sperm count, motility along with elevated abnormal cells, while serum testosterone, follicle stimulating hormone (FSH) leutenizing (LH) levels reduced prominently comparison It remarkably depressed activities catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), as well interleukin-4 (IL-4) interleukin-10 (IL-10), whereas malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) caspase-3, capsase-9, PCR gene expression Bax Bcl2 adversely altered alterations histology. Interestingly, co-treatment blocks blood. inhibited reproductive indices reversed stress-mediated inflammatory stress, apoptotic signaling histopathological abrasions. findings reveal that abrogate through blocking inflammation apoptosis

Language: Английский

Citations

1
Neurotoxic Cocktail of Low-Dose Metals: Investigating the Impact of Environmentally Relevant Lead, Cadmium, Mercury and Arsenic Mixture in Vivo and in Silico DOI
Katarina Živančević, Katarina Baralić, Dragana Vukelić

et al.

Published: Jan. 1, 2023

The assessment of neurotoxic effects lead, cadmium, mercury, and arsenic mixture (MIX) administered at environmentally relevant low doses, was conducted using both in vivo silico approaches. A subacute study on a rat model (number animals per group: 5), consisting control five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 5). Behavioral tests were the last day, brain tissue examined for oxidative stress, pathohistological changes acetylcholinesterase (AChE) activity. Low did not affect spontaneous locomotor activity (SLA), but highest dose showed tendency memory impairment (NORT). Dose-response analysis indicated that even concentrations toxic metals can cause damage (Benchmark methodology). 2 imbalance most narrow BMDI detected superoxide dismutase falling within range 1e-06 3.18e-05 mg As/kg b.w./day. Pathohistological alterations severe 5 group. In (Comparative Toxicogenomics Database) predicted reduction AChE by MIX. This prediction subsequently validated an experiment, demonstrating dose-dependent decrease. current highlights vulnerability mature minimal amounts investigated metal mixture, particularly context early onset cholinergic susceptibility higher doses.

Language: Английский

Citations

0