Exposure to Microplastics Leads to a Decrease in Human Sperm Quality: Evidence from a Coculture System of Human Sperm and Microplastics DOI
Man Wu, Xin Ye, Zhicong Chen

et al.

Published: Jan. 1, 2023

Polystyrene microplastics (PS-MPs) have been shown to impair male fertility. However, most of the existing studies are based on animal models and exposure PS-MPs before sperm maturation. We investigated effects mature fertilization quality apoptosis. exposed human spermatozoa various concentrations (0, 0.1, 1, 10, 100, 1000 μg/mL) for 24h. Our findings revealed a decrease in progressive motility overall sperm, an increase DNA fragmentation. Furthermore, electron microscopy showed evidence mitochondrial shrinkage nuclear vacuoles following PS-MPs. Results from RNA sequencing bioinformatics analysis indicated that had significant impact metabolism, affecting mitochondrial-related pathways, metal ion metabolism apoptosis pathways. Subsequently, we confirmed led reactive oxygen species levels membrane potential. Additionally, observed elevated concentration intra-mitochondrial iron ions. demonstrated prior can result decreased even death, which may be associated with multiple mitochondrial-mediated death

Language: Английский

Microplastics and Oxidative Stress—Current Problems and Prospects DOI Creative Commons
Kornelia Kadac-Czapska, Justyna Ośko, Eliza Knez

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 579 - 579

Published: May 8, 2024

Microplastics (MPs) are plastic particles between 0.1 and 5000 µm in size that have attracted considerable attention from the scientific community general public, as they threaten environment. contribute to various harmful effects, including lipid peroxidation, DNA damage, activation of mitogen-activated protein kinase pathways, cell membrane breakages, mitochondrial dysfunction, lysosomal defects, inflammation, apoptosis. They affect cells, tissues, organs, overall health, potentially contributing conditions like cancer cardiovascular disease. pose a significant danger due their widespread occurrence food. In recent years, information has emerged indicating MPs can cause oxidative stress (OS), known factor accelerating aging organisms. This comprehensive evaluation exposed notable variability reported connection OS. work aims provide critical review whether harmfulness constitute environmental contaminants may result OS through analysis research existing literature, well an assessment characteristics causing Additionally, article covers analytical methodology used this field. The conclusions point necessity for further into effects on

Language: Английский

Citations

54
Acute Exposure to Microplastics Induced Changes in Behavior and Inflammation in Young and Old Mice DOI Open Access

Lauren Gaspar,

Sydney Bartman, Giuseppe Coppotelli

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12308 - 12308

Published: Aug. 1, 2023

Environmental pollutants have become quite ubiquitous over the past two centuries; of those, plastics, and in particular, microplastics (<5 mm), are among most pervasive pollutants. Microplastics (MPs) found their way into air, water system, food chain either purposely produced or derived from breakdown larger plastic materials. Despite societal advancements that plastics allowed, mismanagement waste has a pressing global issue. Pioneering studies on MPs toxicity shown exposure to induces oxidative stress, inflammation, decreased cell viability marine organisms. Current research suggests these transported throughout environment can accumulate human tissues; however, health effects MPs, especially mammals, is still very limited. This led our group explore biological cognitive consequences rodent model. Following three-week treated with fluorescently-labeled pristine polystyrene young old C57BL/6J mice were assessed using behavioral assays, such as open-field light-dark preference, followed by tissue analyses fluorescent immunohistochemistry, Western blot, qPCR. Data assays suggest short-term both changes well alterations immune markers liver brain tissues. Additionally, we noted differed depending age, indicating possible age-dependent effect. These findings need for further better understand mechanisms which may induce physiological changes.

Language: Английский

Citations

45
A Systematic Review of Biomonitoring Microplastics in Environmental Matrices: Emphasis on Airborne Particles, Dry Deposits, and Comparative Analysis with Traditional Methods DOI Creative Commons
Faezeh Jahedi,

Neamatollah Jaafarzadeh Haghighi Fard,

Andrew Turner

et al.

Environmental Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100609 - 100609

Published: Jan. 1, 2025

Language: Английский

Citations

5
Microplastics as vectors for antibiotic resistance genes and their implications for gut health DOI Creative Commons

Neamatollah Jaafarzadeh Haghighi Fard,

Behnam Ahmadi,

Faezeh Jahedi

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Jan. 14, 2025

Microplastic pollution contributes to the rise of antibiotic-resistance. Everyday items like food containers, water bottles, clothing, and cosmetics can increase people's resistance antibiotics. Microplastics in environment serve as a suitable substrate for production "antibiotic-resistant genes" (ARGs). These genes are protected by bacterial chromosomes, phages, plasmids, which biological vectors capable spreading transferring antibiotic-resistance humans, thereby reducing their ability fight infections. In this study, we reviewed several articles that evaluated abundance ARGs changes expression different environments. were observed upon exposure antibiotics such tetracycline, sulfamethoxazole, macrolides, others, well microplastics, nanoplastics, or combination both. To assess impact these stressors on ARG abundance, compiled data from various studies using heatmaps tables abundances tissues By synthesizing information, aimed identify upregulated downregulated response each stressor. Our findings provide insights into potential risks posed environmental pollutants underscore importance understanding dynamics stressors.

Language: Английский

Citations

2
Spatial mapping and risk assessment of microplastic contamination in drinking water catchments from north of the Persian Gulf DOI
Faezeh Jahedi,

Maryam Ravanbakhash,

Neamatollah Jaafarzadeh Haghighi Fard

et al.

Environmental Monitoring and Assessment, Journal Year: 2025, Volume and Issue: 197(4)

Published: March 21, 2025

Language: Английский

Citations

1
Polystyrene nanoplastics exposure triggers spermatogenic cell senescence via the Sirt1/ROS axis DOI Creative Commons

Yuehui Liang,

Yurui Yang,

Chunsheng Lu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116461 - 116461

Published: May 19, 2024

Polystyrene nanoplastics (PS-NPs) have been reported to accumulate in the testes and constitute a new threat reproductive health. However, exact effects of PS-NPs exposure on testicular cells underlying mechanisms remain largely unknown. The C57BL/6 male mice were orally administered with (80 nm) at different dosages (0, 10, 40 mg/kg/day) for 60 days, GC-1 treated this study. Enlarged seminiferous tubule lumens loose vacuolated layer spermatogenic observed PS-NPs-exposed mice. Spermatogenic which may be one target damage, decreased from group. caused undergo senescence, manifested as elevated SA-β-galactosidase activity activated senescence-related signaling p53-p21/Rb-p16 pathways, induced cell cycle arrest. Mechanistically, Gene Ontology (GO) enrichment suggested key role reactive oxygen species (ROS) PS-NPs-induced result was confirmed by measuring ROS levels. Moreover, inhibition partially attenuated senescence phenotype DNA damage. Using health atlas (MHA) database, Sirt1 filtrated critical molecule regulation senescence. overexpression main generator Nox2, downregulated Sirt1, increased p53 acetylated vivo vitro, whereas these disturbances restored pterostilbene. In addition, pterostilbene intervention significantly alleviated burst. Collectively, our study reveals that can trigger mediated regulating Sirt1/ROS axis. Importantly, promising strategy alleviate

Language: Английский

Citations

8
Adverse effects and potential mechanisms of polystyrene microplastics (PS-MPs) on the blood-testis barrier DOI
Jinchen Jiang,

Zhenhao Shu,

Lianglin Qiu

et al.

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(7)

Published: June 7, 2024

Language: Английский

Citations

7
Concerning influences of micro/nano plastics on female reproductive health: focusing on cellular and molecular pathways from animal models to human studies DOI Creative Commons

Hasti Balali,

Ali Morabbi,

Mohammad Karimian

et al.

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 11, 2024

The female reproductive system can face serious disorders and show abnormalities under the influence of environmental pollutants. Microplastics (MPs) nanoplastics (NPs) as emerging pollutants, by affecting different components this system, may make fertility a challenge. Animal studies have demonstrated that exposure to these substances weakens function ovaries causes decrease in ovarian reserve capacity. Also, continuous micro/nano plastics (MNPs) leads increased levels reactive oxygen species, induction oxidative stress, inflammatory responses, apoptosis granulosa cells, reduction number follicles. Furthermore, interfering with hypothalamic-pituitary-ovarian axis, particles disturb normal androgens endocrine balance delay growth gonads. Exposure MNPs accelerate carcinogenesis humans animal models. determined accumulate placenta, causing metabolic changes, disrupting development fetus, endangering health future generations. In humans, presence micro/nanoplastics placenta tissue, infant feces, breast milk has been reported. These directly affect mother increasing risk premature birth other pregnancy complications. This review aims outline hazardous effects on fetal discuss results experiments human research focusing cellular molecular pathways.

Language: Английский

Citations

5
Micro- and nano-plastics in food systems: Distribution, combined toxicity with environmental contaminants, and removal strategies DOI Open Access
Haopeng Wang, Xu-Hui Huang, Jianan Chen

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146430 - 146430

Published: Oct. 5, 2023

Language: Английский

Citations

10
Effects of microplastics on the immune system: How much should we worry? DOI Creative Commons
Claudia Vanetti,

Martina Broggiato,

Stefania Pezzana

et al.

Immunology Letters, Journal Year: 2025, Volume and Issue: 272, P. 106976 - 106976

Published: Feb. 1, 2025

Plastics are everywhere. It is widely recognized that they represent a global problem, the extent of which yet to be defined. Humans broadly exposed plastics, whose effects and consequences poorly characterized so far. The main route exposure via alimentary respiratory intake. pollutions may come from both: water food contamination itself, their packaging. smaller sizes (i.e. microplastics <150 µm - MPs) considered most pervasive living organisms and, therefore, potentially harmful. As humans occupy one apex positions chain, we bioaccumulation biomagnification MPs. In fact, MPs commonly found in human stools blood. However, there no data available on ability accumulate produce detrimental biological systems. Even though plastics pollution studied mammals, including humans, appear have inflammatory effects, rather concerning as many etiologies disease based pro-inflammatory status.

Language: Английский

Citations

0