Cited by Extraction, Structural Characterization, and Antioxidant Activity Of Polysaccharides from Three Microalgae

Extraction, structural characterization, and antioxidant activity of polysaccharides from three microalgae DOI

Yang Zhao,

Chun Han,

Yangyingdong Wu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 931, P. 172567 - 172567

Published: April 20, 2024

Language: Английский

Citations

Total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack prevents acetaminophen-induced liver injury by activating Keap1/Nrf2 and PI3K/AKT/mTOR signaling pathway DOI

Meiqi Guo,

Wenwen Fu,

Xiaoze Zhang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119562 - 119562

Published: Feb. 1, 2025

Language: Английский

Citations

6′-O-caffeoylarbutin attenuates D-galactose-induced brain and liver damage in aging mice via regulating SIRT1/NF-κB pathway DOI

Yongpeng Wang, Yongchao Wang,

Tianrui Zhao

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156710 - 156710

Published: March 1, 2025

Language: Английский

Citations

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway DOI

Yongchao Wang, Yongpeng Wang,

Tianrui Zhao

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1384 - 1384

Published: March 20, 2024

Que Zui tea (QT) is an important herbal in the diet of ‘Yi’ people, ethnic group China, and it has shown significant antioxidant, anti-inflammatory, hepatoprotective effects vitro. This study aims to explore protective aqueous-ethanol extract (QE) taken from QT against ᴅ-galactose (ᴅ-gal)-induced oxidative stress damage mice its potential mechanisms. QE was identified as UHPLC-HRMS/MS for chemical composition possible bioactive substances. Thus, rich phenolic flavonoid compounds. Twelve compounds were identified, main components which chlorogenic acid, quinic 6′-O-caffeoylarbutin. Histopathological biochemical analysis revealed that significantly alleviated brain, liver, kidney ᴅ-gal-treated mice. Moreover, remarkably attenuated by activating Nrf2/HO-1 pathway increase expression antioxidant indexes, including GSH, GSH-Px, CAT, SOD, T-AOC. In addition, administration could inhibit IL-1β IL-6 levels, suppress inflammatory response. noticeably alleviate apoptosis inhibiting expressions Caspase-3 Bax proteins brains, livers, kidneys The anti-apoptosis mechanism may be related upregulation SIRT1 protein downregulation p53 induced tissues Molecular docking demonstrated QE, 6′-O-caffeoylarbutin, robustaside A, had good binding ability with Nrf2 proteins. present indicated ᴅ-gal-induced liver cell apoptosis; additionally, associated SIRT1/Nrf2 signaling pathway.

Language: Английский

Citations

Acute, subacute, and sub‐chronic toxicity evaluation of Bletilla formosana tubers in rats DOI

Yongchao Wang, Jian Zhang,

Tianrui Zhao

et al.

Food Safety and Health, Journal Year: 2024, Volume and Issue: 2(1), P. 117 - 132

Published: Jan. 1, 2024

Abstract Bletilla formosana (Hayata) Schltr. is an important economic medicinal and edible plant in China. Its tubers (BFTs) are traditionally consumed as a beverage canned foods for promoting human health. In this paper, the nutrients, contents of total phenol, flavonoids, polysaccharides, safety toxicity BFT determined. The chemical analysis reported that rich proteins, polyphenols, trace elements. acute (14 days), subacute (28 sub‐chronic (90 days) toxicities were evaluated first time female male rats. An study showed rats by single oral administrations with 10,000 mg/kg body weight (BW) did not have behavioral changes mortality, indicating 50% lethal dose (LD50) was over BW. Similarly, at 5000 BW consecutive 28 90 days also toxic after physiological biochemical parameters. Additionally, there no significant differences on histopathological heart, liver, spleen, lung, kidney, ovary, or testis between control groups. Our findings revealed concentration less than safe rats, could be regarded food source.

Language: Английский

Citations

A novel approach combining network pharmacology and experimental validation to study the protective effect of ginsenoside Rb1 against cantharidin‐induced hepatotoxicity in mice DOI

Lijuan Xiong, Kexin Lin, Tianmu He

et al.

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2024, Volume and Issue: 134(5), P. 737 - 749

Published: March 13, 2024

Cantharidin (CTD) is a widely used anticancer compound, but its clinical use mainly limited due to hepatotoxicity. Ginsenoside Rb1 (GRb1) shows potential hepatoprotective effects. Nonetheless, the protective effect and underlying mechanism of GRb1 against CTD-induced hepatotoxicity in mice have not been investigated. This study aims elucidate on using network pharmacology vivo experiments. Network studies shown that 263 targets were main mechanisms by which alleviates KEGG enrichment analysis revealed 75 hub genes enriched TNF, IL-17 apoptosis signalling pathways. Molecular docking showed exhibited high affinity with Akt1, Tnf, Il6, Bcl2 Caspase3. In addition, results from animal demonstrated could ameliorate inhibiting protein expression Caspase-3, Caspase-8, Bcl-2/Bax, GRP78, ATF6, ATF4, CHOP, IRE1α PERK. research endoplasmic reticulum stress (ERS) it may provide scientific rationale for treatment induced CTD.

Language: Английский

Citations

Plant-Derived Nrf2 Activators to Enhance Liver Antioxidative and Regenerative Potentials DOI

Tong-Xuan Tee, Li Ting Kee, Tsun‐Thai Chai

et al.

Revista Brasileira de Farmacognosia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

Language: Английский

Citations

Extraction, Structural Characterization, and Antioxidant Activity Of Polysaccharides from Three Microalgae DOI

Yang Zhao,

Chun Han,

Yangyingdong Wu

et al.

Published: Jan. 1, 2024

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Language: Английский

Citations