Pathological consequences, metabolism and toxic effects of trichothecene T-2 toxin in poultry

Poultry Science, Journal Year: 2024, Volume and Issue: 103(3), P. 103471 - 103471

Published: Jan. 17, 2024

Contamination of feed with mycotoxins has become a severe issue worldwide. Among the most prevalent trichothecene mycotoxins, T-2 toxin is particular importance for livestock production, including poultry posing significant threat to animal health and productivity. This review article aims comprehensively analyze pathological consequences, metabolism, toxic effects in poultry. Trichothecene primarily produced by Fusarium species, are notorious their potent toxicity. exhibits broad spectrum negative on leading substantial economic losses as well concerns about welfare food safety modern agriculture. exposure easily results consequences gastrointestinal tract, parenchymal tissues like liver (as key organ its metabolism), kidneys, or reproductive organs. In addition, it also intensely damages immune system-related such spleen, bursa Fabricius, thymus causing immunosuppression increasing susceptibility animals infectious diseases, making immunization programs less effective. The cellular processes transcriptional translational levels induces apoptosis through activation numerous signaling cascades. Furthermore, according recent studies, besides direct abovementioned processes, production reactive molecules free radicals resulting oxidative distress concomitantly occurring damage. conclusion, this provides complex detailed overview mechanism action immunomodulatory stress-related toxin. Understanding these crucial developing strategies mitigate impact avian future.

Language: Английский

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Review of neurotoxicity of T-2 toxin

Mycotoxin Research, Journal Year: 2024, Volume and Issue: 40(1), P. 85 - 95

Published: Jan. 13, 2024

Language: Английский

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T-2 Toxin Nephrotoxicity: Toxic Effects, Mechanisms, Mitigations, and Future Perspectives

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

T-2 toxin is a highly toxic fungal that threatens humans and animals' health. As major detoxifying metabolic organ, the kidney also target of toxin. This article reviews nephrotoxicity research progress, covering renal structure function damage, mechanisms, detoxification methods to future directions. damages structure, causing dysfunction. The mechanism involves multiple factors including oxidative stress, endoplasmic reticulum mitophagy, inflammatory responses, apoptosis, which are intertwined interdependent. Current strategies mainly involve reducing in feedstuff using antioxidant substances, but both have limits. Future should focus on cells sensitivity toxin, exploring key molecules toxin's nephrotoxicity, injury's impact other organs, better methods. review aims guide underpin toxin-induced prevention treatment.

Language: Английский

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New insights into the mechanism of T-2 toxin cytotoxicity: stress granules inhibit the mTORC2/AKT signaling pathway

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106806 - 106806

Published: May 1, 2025

Language: Английский

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Tibial Damage Caused by T-2 Toxin in Goslings: Bone Dysplasia, Poor Bone Quality, Hindered Chondrocyte Differentiation, and Imbalanced Bone Metabolism

Animals, Journal Year: 2024, Volume and Issue: 14(15), P. 2281 - 2281

Published: Aug. 5, 2024

T-2 toxin, the most toxic type A trichothecene, is widely present in grain and animal feed, causing growth retardation tissue damage poultry. Geese are more sensitive to toxin than chickens ducks. Although has been reported cause tibial plate (TGP) chondrodysplasia chickens, caused by geese not fully demonstrated. This study aims investigate adverse effects of on bone development, quality, chondrocyte differentiation, metabolism. Here, forty-eight one-day-old male Yangzhou goslings were randomly divided into four groups daily gavaged with at concentrations 0, 0.5, 1.0, 2.0 mg/kg body weight for 21 days, respectively. The development gosling size was determined weighing taking measurements after exposure different toxin. Changes characteristics radiographic examination, phenotypic measurements, quality composition analyses. Chondrocyte differentiation TGP metabolism characterized cell morphology, gene-specific expression, serum marker levels. Results showed that treatment resulted a lower weight, volume, length, middle width, circumference tibia dose-dependent manner (

Language: Английский

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Preparation of rabbit monoclonal antibody against T-2 toxin and development of enzyme-linked immunosorbent assay in milk, feed and pork samples

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111977 - 111977

Published: Oct. 1, 2024

Language: Английский

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New insight into mycotoxins and bacterial toxins: Toxicity assessment, molecular mechanism and food safety (preface to the special issue of food and chemical toxicology on the outcomes of Myco & bacterial toxin)

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 188, P. 114655 - 114655

Published: April 11, 2024

Language: Английский

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Rigidifying Aggregation-induced Emission Luminogens by Metal–Organic Framework Formation for Sensitive Lateral Flow Immunoassay

Talanta, Journal Year: 2024, Volume and Issue: 283, P. 127092 - 127092

Published: Oct. 22, 2024

Language: Английский

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