Targeting TLR4/NF-κB signaling, oxidative stress, and apoptosis by farnesol mitigates cadmium-induced testicular toxicity in rats

Tissue and Cell, Journal Year: 2025, Volume and Issue: 94, P. 102813 - 102813

Published: Feb. 22, 2025

Language: Английский

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Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice

Life Sciences, Journal Year: 2024, Volume and Issue: 348, P. 122688 - 122688

Published: May 4, 2024

Language: Английский

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The protective role of melatonin and agomelatine against oxidative stress following laparoscopic ovariectomy in dogs

BMC Veterinary Research, Journal Year: 2025, Volume and Issue: 21(1)

Published: March 31, 2025

The present study was carried out to compare biomarkers of oxidative stress and antioxidant activity agomelatine melatonin in bitches undergoing laparoscopic ovariectomy. Twenty-four healthy female dogs were randomly divided into four groups: Control (C), ovariectomy (LO), + (ALO), (MLO) consisting 6 animals each. Melatonin administered the MLO group (0.3 mg/kg/day, p.o) ALO consequently one day before LO 7 days post-intervention. Blood sampling performed on − 1, 0 (immediately after surgery), 3, 8 study. Total oxidant status (TOS), total capacity (TAC), malondialdehyde (MDA) sera superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) hemolyzed red blood cells (RBCs) measured. Among all indices analyzed over time, only MDA index showed a significant difference, being significantly lower 3 post-surgery compared 1 (p = 0.023). Significant differences observed between groups terms TOS, TAC, GPx, SOD levels. exhibited increase TOS other 0.008). TAC experienced most 0.005), this trend continued until comparison C 0.024). Agomelatine increased levels postoperative 0.009). GPx elevated 0.003). results demonstrate that melatonin, by increasing capacity, agomelatine, through enzymatic pathways, contributed reduction free radical dogs. revealed administering could decrease up 3.

Language: Английский

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Agomelatine Alleviates Depressive-like Behaviors by Suppressing Hippocampal Oxidative Stress in the Chronic Social Defeat Stress Model

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 410 - 410

Published: March 28, 2025

Major depressive disorder (MDD) is a common psychiatric characterized by significant mood disturbances and cognitive impairments. Chronic stress, particularly social defeat plays crucial role in the etiology of depression, with oxidative stress being pivotal factor its pathophysiology. Consequently, identifying effective strategies to mitigate prevent progression depression paramount importance. Agomelatine, an atypical antidepressant melatonergic serotonergic properties, has shown promise treating MDD due unique mechanisms action. In this study, we aimed investigate whether agomelatine could ameliorate behavioral deficits chronic (CSDS) mouse model. CSDS mice were administered (50 mg/kg, intraperitoneally) exhibited reductions both anxiety-like depressive-like behaviors tests. Further analysis revealed that treatment effectively reduced damage hippocampus mice. Additionally, attenuated mitochondrial dysfunction restored synaptic plasticity, as evidenced increased density excitatory synapses enhanced neuronal activity. These findings suggest may exert therapeutic effects reducing preserving function, enhancing providing new insights into potential for stress-induced depression.

Language: Английский

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β-Caryophyllene attenuates cadmium induced neurotoxicity in rats by modulating different cellular signaling pathways

NeuroToxicology, Journal Year: 2025, Volume and Issue: 108, P. 206 - 217

Published: April 14, 2025

Language: Английский

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Farnesol attenuates cadmium-induced kidney injury by mitigating oxidative stress, inflammation and necroptosis and upregulating cytoglobin and PPARγ in rats

Tissue and Cell, Journal Year: 2024, Volume and Issue: 90, P. 102526 - 102526

Published: Aug. 17, 2024

Language: Английский

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Epicatechin ameliorates glucose intolerance and hepatotoxicity in sodium arsenite-treated mice

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 192, P. 114950 - 114950

Published: Aug. 24, 2024

Language: Английский

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MELATONIN EFFECTS ON OXIDATIVE STRESS AND ON TLR4/NF-kβ INFLAMMATORY PATHWAY IN THE RIGHT VENTRICLE OF RATS WITH PULMONARY ARTERIAL HYPERTENSION

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 592, P. 112330 - 112330

Published: July 11, 2024

Language: Английский

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Adverse effects of cadmium on lymphoid organs, immune cells, and immunological responses

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Humans and animals possess robust immune systems to safeguard against foreign pathogens. However, recent reports suggest a greater incidence of immunity breakdown due exposure environmental pollutants, with heavy metals emerging as potential candidates in such immuno‐toxicological studies. While we have extensive data on the general toxicity resulting from metals, comprehensive documentation their role disruptors remains scarce. Cd (Cadmium) exerts immunomodulation by interfering organs cells, leading altered structure, physiology, function, thereby inducing symptoms deregulation, inflammation and/or autoimmunity. This review aims summarize link between dysfunction, drawing case studies exposed human subjects, well research conducted various model organisms in‐vitro culture systems.

Language: Английский

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Attenuation of inflammation, oxidative stress and TGF-β1/Smad3 signaling and upregulation of Nrf2/HO-1 signaling mediate the protective effect of diallyl disulfide against cadmium nephrotoxicity

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102576 - 102576

Published: Sept. 27, 2024

Language: Английский

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