Targeting TLR4/NF-κB signaling, oxidative stress, and apoptosis by farnesol mitigates cadmium-induced testicular toxicity in rats

Tissue and Cell, Journal Year: 2025, Volume and Issue: 94, P. 102813 - 102813

Published: Feb. 22, 2025

Language: Английский

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Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117587 - 117587

Published: Jan. 1, 2025

Chlorpyrifos (CPF) is a broad-spectrum organophosphate chloride (OP) insecticide widely used in domestic use and open field. However, there currently no relevant research revealing the toxic effects of CPF exposure on skin, then it necessary to comprehensively understand mechanisms. The results showed that skin tissue structure function mice were significantly disrupted after exposure. Furthermore, PPI network analysis molecular docking experiments pinpointed core targets such as Bcl2, EGFR, Caspase-3, TNF-α, IL-1β, VEGF. Additionally, through KEGG analysis, VEGF apoptosis signaling pathways identified pivotal implicated CPF-induced toxicity. These subsequently confirmed animal experimentation. In conclusion, our study suggests primarily induces damage by disrupting function, mediated proliferation processes cells, alongside aberrant angiogenesis heightened inflammatory response. insights are expected advance development preventive therapeutic strategies aimed at mitigating adverse skin.

Language: Английский

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Farnesol Improves Endoplasmic Reticulum Stress and Hepatic Metabolic Dysfunction Induced by Tunicamycin in Mice

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 213 - 213

Published: Feb. 18, 2025

Endoplasmic reticulum (ER) stress significantly affects liver metabolism, often leading to disorders such as hepatic steatosis. Tunicamycin (TM), a known ER inducer, is frequently used model metabolic stress, but its specific effects on energy homeostasis remain unclear. This study investigates how farnesol (FOH), natural compound with antioxidant and anti-inflammatory properties, counteracts TM-induced associated disruptions in the liver. Using both primary hepatocytes mouse model, this demonstrates that TM treatment caused upregulation of markers, including ATF4, disrupted genes related lipid metabolism gluconeogenesis. Co-treatment FOH reduced these markers restored expression genes. In vivo, alleviated oxidative accumulation, normal glycogen metabolism. Histological analysis further confirmed preserved architecture minimized cellular damage. also stabilized serum profiles modulated key biomarkers, suggesting protective role against injury. These findings suggest has therapeutic potential mitigating stress-related dysfunctions, offering promising insights for diseases linked stress.

Language: Английский

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ROS acted as an initial role in selenium nanoparticles alleviating insecticide chlorpyrifos-induced oxidative stress, pyroptosis, and intestinal barrier dysfunction in porcine intestinal epithelial cells

Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 106418 - 106418

Published: April 1, 2025

Language: Английский

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Farnesol attenuates cadmium-induced kidney injury by mitigating oxidative stress, inflammation and necroptosis and upregulating cytoglobin and PPARγ in rats

Tissue and Cell, Journal Year: 2024, Volume and Issue: 90, P. 102526 - 102526

Published: Aug. 17, 2024

Language: Английский

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Attenuation of inflammation, oxidative stress and TGF-β1/Smad3 signaling and upregulation of Nrf2/HO-1 signaling mediate the protective effect of diallyl disulfide against cadmium nephrotoxicity

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102576 - 102576

Published: Sept. 27, 2024

Language: Английский

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