Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 2, 2024

The increase in female reproductive disorders, such as polycystic ovary syndrome, endometriosis, and diminished ovarian reserve that lead to subfertility infertility, has encouraged researchers search discover their underlying causes risk factors. One of the crucial factors may influence increasing number issues is environmental pollution, particularly exposure man-made endocrine-disrupting chemicals (EDCs). EDCs can interfere with microenvironment, impacting not only granulosa cell function but also other surrounding cells follicular fluid (FF), which all play essential roles for oocyte development, maturation, overall function. FF surrounds developing oocytes within an follicle represents a dynamic milieu. are usually found biological fluids, therefore interest this respect. This narrative review examines current knowledge on specific classes EDCs, including industrial chemicals, pesticides, plasticizers, known effects hormonal signaling pathways, gene expression, mitochondrial function, oxidative stress induction, inflammation FF. We describe impact development quality, menstrual cycle regulation, effect assisted technique outcomes. potential transgenerational offspring through animal first-human studies been considered also. While significant progress made, understanding EDCs’ humans, remains limited, underscoring need further research clarify actions ovary.

Language: Английский