Materialia, Journal Year: 2023, Volume and Issue: 32, P. 101923 - 101923
Published: Oct. 7, 2023
Language: Английский
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 319, P. 121193 - 121193
Published: July 11, 2023
Language: Английский
Citations
52
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 492, P. 152288 - 152288
Published: May 20, 2024
Language: Английский
Citations
23
Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 2099 - 2126
Published: Jan. 1, 2024
Exosomes, which are small vesicles enclosed by a lipid bilayer and released many cell types, widely dispersed have garnered increased attention in the field of regenerative medicine due to their ability serve as indicators diseases agents with therapeutic potential. Exosomes play crucial role mediating intercellular communication through transfer biomolecules, including proteins, lipids, RNA, other molecular constituents, between cells. The targeted transport proteins nucleic acids specific cells has potential enhance or impair biological functions. applications, they can be used alone combination approaches. examination unique attributes functions these factors emerged prominent study realm biomedical research. This manuscript summarizes origins properties exosomes, structural, biological, physical, chemical aspects. paper offers complete recent progress tissue repair medicine, emphasizing possible implications methods forthcoming regeneration attempts.
Language: Английский
Citations
20
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 327, P. 121673 - 121673
Published: Dec. 9, 2023
Language: Английский
Citations
41
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: Aug. 13, 2024
Abstract The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as blood-retinal barrier and corneal impermeability. Conventional administration methods often fail sustain therapeutic levels may compromise patient safety compliance. Polysaccharide-based microneedles (PSMNs) have emerged transformative solution for ophthalmic delivery. However, comprehensive review of PSMNs in ophthalmology has not been published date. In this review, we critically examine synergy between polysaccharide chemistry microneedle technology enhancing ocular We provide thorough analysis PSMNs, summarizing design principles, fabrication processes, addressed during fabrication, including improving comfort also describe recent advances performance various both research clinical scenarios. Finally, current regulatory frameworks market barriers that are relevant commercial advancement final perspective on area.
Language: Английский
Citations
10
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129961 - 129961
Published: Feb. 3, 2024
Language: Английский
Citations
9
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136276 - 136276
Published: Oct. 9, 2024
Language: Английский
Citations
8
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 8, 2024
Abstract Photothermal therapy (PTT) is widely used in wound healing because it produces heat under near‐infrared irradiation, eliminating bacterial infections. However, excessive production of reactive oxygen species (ROS) occurs during PTT, which causes oxidative stress damage. In this study, a nanozyme, PDA‐MnO 2 (PM), synthesized and encapsulated the needle tip layer bi‐layer GelMA microneedle patch (PbMP), has excellent mechanical properties can easily penetrate skin. study involving an SD rat model infected with S. aureus , PbMP significantly accelerated process bacterially challenged wounds, resulting better blood vessel growth, cell proliferation, collagen biosynthesis than other dressings. The experiment shows that PM nanoparticles improve photothermal conversion efficiency activate SOD CAT, efficient cascade enzyme reaction system to eliminate ROS PTT process. This describes highly effective nanozyme hydrogel platform synergistic antibacterial effects on healing.
Language: Английский
Citations
4
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Reactive oxygen species (ROS) play a dual role in wound healing. They act as crucial signaling molecules and antimicrobial agents when present at moderate levels. However, excessive levels of ROS can hinder the healing process for individuals with diabetes. As result, targeting to maintain redox balance has become promising strategy improving recovery. Currently, no biomaterials have been reported simultaneously up-regulate down-regulate achieve broad-spectrum antibacterial antioxidant properties. Inspired by site-dependent effect nanomaterials, micron-sized ferroferric oxide (Fe3O4)/MXene (FM) heterojunction is synthesized using hydrothermal method. The FM could scavenge extracellular activating catalase (CAT)-like superoxide dismutase (SOD)-like nanozyme activities. Meanwhile, release ferric ions ferrous defect engineering induce bacterial ferroptosis, up-regulating intercellular ROS, lipid peroxidation. For applications vivo, incorporated into tips gelatin methacryloyl (GelMA)-based microneedle (termed GFM microneedle) two-step casting technique. results showed that combined photothermal therapy improve S. aureus-infected skin regeneration diabetic rats. effectiveness safety are not less favorable than commercial dressing. This study provides proof-of-concept heterojunction-mediated regenerative medicine via ROS-targeting strategy.
Language: Английский
Citations
0
Fundamental Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Citations
0