Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: April 21, 2022
Abstract
Aging
has
become
a
concern
for
many
people,
especially
women.
Given
that
high-quality
anti-aging
products
are
of
high
cost;
it
imperative
to
search
other
economical
sources.
Essential
oils
frequently
used
in
cosmetics
due
wide
range
biological
activities
as
well
their
pleasant
odor.
The
current
study
aimed
investigate
the
biochemical
effect
cosmetic
potential
selected
Apiaceous
essential
oils,
traditionally
skincare,
by
evaluating
anti-wrinkle
activity.
It
is
worth
noting
that,
coriander
oil
showed
highest
collagenase,
elastase,
tyrosinase,
and
hyaluronidase
inhibitory
compared
(fennel,
anise,
cumin).
GC–MS
proved
very
level
oxygenated
monoterpenes,
with
linalool
(81.29%)
most
abundant
constituent.
Intriguingly,
cream
Coriander
Oil-loaded
Lipid
Nanoparticles
(CEOLNs)
formulations
attenuated
vivo
UV-induced
skin
photoaging
was
manifested
significantly
decreased
MDA,
COX-2,
PGE-2,
MMP-1,
JNK,
AP-1
levels.
Moreover,
these
pharmaceutical
dosage
forms
increased
collagen
content
UV-injured
group.
Also,
TGFβ,
TGFβII,
SMAD3
protein
expression
levels
In
conclusion,
possess
could
have
an
auspicious
role
amending
extrinsic
aging.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42479 - e42479
Published: Feb. 1, 2025
Cholinesterase
enzymes
(BuChE
and
AChE)
are
privileged
biological
targets
for
the
symptomatic
treatment
of
Alzheimer's
disease.
Indeed,
inhibition
cholinesterase
has
been
proven
to
improve
neurotransmission
mechanisms
in
disease
patients.
In
this
investigation,
we
attempt
highlight
new
inhibitors
from
natural
products.
For
purpose,
secondary
metabolites
(299
phytoconstituents)
twenty-eight
Medicinal
plants
were
virtually
screened
using
molecular
docking,
pharmacokinetic
toxicological
analysis.
Ten
phytoconstituents
(L82,
L86,
L92,
L121,
L148,
L187,
L211,
L221,
L228)
exhibited
their
high
binding
affinity
with
BuChE,
five
phytoconstituents,
namely
L119,
L147,
L149,
L192
L193,
strong
ability
AChE.
Subsequently,
these
evaluated
ADMET
properties.
As
result,
L221
is
predicted
be
highly
bioavailable
readily
absorbed
by
human
intestinal
tract
without
significant
toxicity
concerns,
making
it
suitable
oral
administration.
Crucially,
can
penetrate
blood-brain
barrier
(BBB),
allowing
effectively
reach
central
nervous
system.
Molecular
dynamics
simulations
MM-PBSA
analysis
revealed
that
best-screened
phytoconstituent
form
thermodynamically
favorable
stable
complex
BuChE
site.
The
conducted
investigations
highlighted
promising
outcomes
orient
towards
rational
development
effective
inhibitors.
Foods,
Journal Year:
2025,
Volume and Issue:
14(4), P. 673 - 673
Published: Feb. 17, 2025
Microbial
foods
include
microbial
biomass,
naturally
fermented
foods,
and
heterologously
synthesized
food
ingredients
derived
from
fermentation.
Terpenoids,
using
isoprene
as
the
basic
structure,
possess
various
skeletons
functional
groups.
They
exhibit
diverse
physicochemical
properties
physiological
activities,
such
unique
flavor,
anti-bacterial,
anti-oxidant,
anti-cancer,
hypolipemic,
making
them
extensively
used
in
industry,
fragrance,
preservatives,
dietary
supplements,
medicinal
health
food.
Compared
to
traditional
strategies
like
direct
extraction
natural
species
chemical
synthesis,
cell
factories
for
edible
terpenoids
have
higher
titers
yields.
can
utilize
low-cost
raw
materials
are
easily
scaling-up,
representing
a
novel
green
sustainable
production
mode.
In
this
review,
we
briefly
introduce
synthetic
pathway
of
applications
producing
terpenoids.
Secondly,
highlight
several
typical
non-typical
chassis
terpenoid-producing
factories.
addition,
reviewed
recent
advances
representative
terpenoid
with
gram-scale
titer
preservation,
nutritional
enhancers,
foods.
Finally,
predict
future
directions
their
commercialization
process.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(18), P. 10334 - 10334
Published: Sept. 7, 2022
Plants
produce
a
variety
of
high-value
chemicals
(e.g.,
secondary
metabolites)
which
have
plethora
biological
activities,
may
be
utilised
in
many
facets
industry
agrisciences,
cosmetics,
drugs,
neutraceuticals,
household
products,
etc.).
Exposure
to
various
different
environments,
as
well
their
treatment
exposure
chemicals),
can
influence
the
chemical
makeup
these
plants
and,
turn,
will
prevalent
within
them.
Essential
oils
(EOs)
usually
complex
compositions
(>300
organic
compounds,
e.g.,
alkaloids,
flavonoids,
phenolic
acids,
saponins
and
terpenes)
are
obtained
from
botanically
defined
plant
raw
materials
by
dry/steam
distillation
or
suitable
mechanical
process
(without
heating).
In
certain
cases,
an
antioxidant
added
EO
(EOs
produced
more
than
17,500
species
plants,
but
only
ca.
250
EOs
commercially
available).
The
interesting
bioactivity
renders
them
high
value,
motivating
investment
production,
extraction
analysis.
Traditional
methods
for
effectively
extracting
plant-derived
biomolecules
include
cold
pressing
hydro/steam
distillation;
newer
solvent/Soxhlet
extractions
sustainable
processes
that
reduce
waste,
decrease
processing
times
deliver
competitive
yields,
examples
microwave-assisted
(MAE),
ultrasound-assisted
(UAE),
subcritical
water
(SWE)
supercritical
CO2
(scCO2).
Once
extracted,
analytical
techniques
such
chromatography
mass
spectrometry
used
analyse
contents
extracts
given
feedstock.
bioactive
components,
formulations
products
displaying
anti-aging,
antibacterial,
anticancer,
anti-depressive,
antifungal,
anti-inflammatory,
antioxidant,
antiparasitic,
antiviral
anti-stress
properties),
biorenewable
chemicals.
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: April 21, 2022
Abstract
Aging
has
become
a
concern
for
many
people,
especially
women.
Given
that
high-quality
anti-aging
products
are
of
high
cost;
it
imperative
to
search
other
economical
sources.
Essential
oils
frequently
used
in
cosmetics
due
wide
range
biological
activities
as
well
their
pleasant
odor.
The
current
study
aimed
investigate
the
biochemical
effect
cosmetic
potential
selected
Apiaceous
essential
oils,
traditionally
skincare,
by
evaluating
anti-wrinkle
activity.
It
is
worth
noting
that,
coriander
oil
showed
highest
collagenase,
elastase,
tyrosinase,
and
hyaluronidase
inhibitory
compared
(fennel,
anise,
cumin).
GC–MS
proved
very
level
oxygenated
monoterpenes,
with
linalool
(81.29%)
most
abundant
constituent.
Intriguingly,
cream
Coriander
Oil-loaded
Lipid
Nanoparticles
(CEOLNs)
formulations
attenuated
vivo
UV-induced
skin
photoaging
was
manifested
significantly
decreased
MDA,
COX-2,
PGE-2,
MMP-1,
JNK,
AP-1
levels.
Moreover,
these
pharmaceutical
dosage
forms
increased
collagen
content
UV-injured
group.
Also,
TGFβ,
TGFβII,
SMAD3
protein
expression
levels
In
conclusion,
possess
could
have
an
auspicious
role
amending
extrinsic
aging.
