Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(22), P. 12340 - 12355

Published: May 22, 2024

Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function potentially triggering apoptosis or necrosis. This process is closely correlated with onset many diseases. Evidence suggests that phenolic hydroxyl groups food-borne plant polyphenols (FPPs) make them effective antioxidants capable preventing diseases triggered by membrane LP. Proper dietary intake FPPs can attenuate oxidative stress, especially damage phospholipids, activating Nrf2/GPx4 pathway. Nuclear factor E2-related 2 (Nrf2) an stress antagonist. The signaling pathway regulated Nrf2 a defense transduction organism against external stimuli such as reactive oxygen species exogenous chemicals. Glutathione peroxidase 4 (GPx4), under regulation Nrf2, only enzyme reduces lipid peroxides specificity, thus playing pivotal role regulating ferroptosis counteracting stress. study explored mechanism, antioxidant activity FPPs, mechanism It also highlighted bioprotective properties LP its associated mechanisms, including (i) activation pathway, GPx4 serving central target protein, (ii) activities, leading reduction production ROS other peroxides, (iii) effects on downstream phospholipid structure. In conclusion, play crucial natural However, further in-depth analysis coregulation multiple pathways required, combined these mechanisms need evaluation experimental models. Human trials could provide valuable insights into new directions for research application.

Language: Английский

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Structure information analysis and relative content determination of protein and chitin from yellow mealworm larvae using Raman spectroscopy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 272, P. 132787 - 132787

Published: June 1, 2024

Language: Английский

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Photocatalytic degradation of the pesticide pyridaben: Identification of degradation pathways using SERS and GC–MS

Food Research International, Journal Year: 2025, Volume and Issue: 202, P. 115738 - 115738

Published: Jan. 13, 2025

Language: Английский

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Alleviates Effects of γ-cyclodextrin/Genistein Inclusion Complex on Oxidative Stress Injury Induced by Organic Hydrogen Peroxide in PC12 Cells via Nrf2/GPx4 Signaling Pathway

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105631 - 105631

Published: Dec. 1, 2024

Language: Английский

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