Public Health Threats Posed by Biofilms and Innovative Strategies for their Control DOI Open Access

Syed Hamza Abbas,

Shahzar Khan,

M.J. Shah

et al.

Discoveries, Journal Year: 2024, Volume and Issue: 12(4), P. e197 - e197

Published: Dec. 31, 2024

Biofilms are communities of microorganisms that adhere to surfaces within a self-produced protective matrix. The structural complexity biofilms and their inherent resistance conventional antimicrobial treatments make them significant public health challenge. These microbial communities, embedded extracellular matrix, associated with numerous persistent infections, especially those occurring in healthcare settings where they colonize medical devices chronic wounds. effects go beyond environments persist water treatment facilities, food processing plants, nature, which aid pollution transmission disease. This review article discusses multifaceted complications related the search for existing control strategies, process biofilm formation, mechanisms persistence, limitations traditional approaches. Additionally, this explores new innovative solutions, such as bacteriophage therapy, matrix-degrading enzymes, quorum sensing inhibitors. potential combination agents biofilm-disrupting compounds improvement efficacy is also paid special attention. seeks contribute these ongoing efforts by presenting an overview biology assessing variety possible strategies. Subsequently, insights derived from study may be used inform future research directions development more effective interventions biofilm-associated infections contamination various settings.

Language: Английский

A Comprehensive Review of Honey-Containing Hydrogel for Wound Healing Applications DOI Creative Commons
Azalina Zainuddin,

Nurul Nadhirah Mustakim,

Farah Alea Rosemanzailani

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 194 - 194

Published: March 12, 2025

Honey has long been recognized for its medicinal properties, particularly in wound healing. Recent advancements material science have led to the development of honey-containing hydrogels, combining natural healing properties honey with versatile characteristics hydrogel matrices. These hydrogels offer numerous advantages, including high moisture retention, biocompatibility, and controlled release bioactive compounds, making them highly effective applications. Hydrogels hold significant potential advancing medical applications, cutaneous injuries. The diverse honey, antimicrobial, anti-inflammatory, anti-eschar effects, shown promise accelerating tissue regeneration. According studies, they are maintaining a good swelling ratio index, Water Vapour Transmission Rate (WVTR), contact angle, tensile elongation at break, vitro biodegradation rate, viscosity porosity analysis, lowering bacterial infections, encouraging rapid regeneration notable FTIR peaks SEM average pore sizes. However, limitations such as low bioavailability inefficiencies direct application reduce their therapeutic effectiveness site. Integrating into can help preserve mechanisms while enhancing ability facilitate skin recovery. This review explores underlying management presents an extensive analysis reported literature over past eight years. It emphasizes physicochemical mechanical honey-incorporated promoting regeneration, supported by evidence from both vivo studies. While honey-based therapies demonstrated promising outcomes animal clinical studies remain limited. Despite that, honey’s incorporation systems, however, offers potent fusion contemporary technology qualities, marking substantial breakthrough treatment.

Language: Английский

Citations

1
Synergistic Antibiofilm Effects of Chestnut and Linden Honey with Lavender Essential Oil Against Multidrug-Resistant Otitis Media Pathogens DOI Creative Commons

Virág D. Ángyán,

Viktória Lilla Balázs, Marianna Kocsis

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 146 - 146

Published: Feb. 2, 2025

Background/Objectives: Bacterial resistance to antibiotics is a major problem in healthcare, complicated by the ability of bacteria form biofilms. Complementary therapy for infectious diseases can rely on natural substances with antibacterial activity, e.g., essential oils and honeys. The aim study was investigate effects linden chestnut honeys, lavender oil, their combinations against multidrug-resistant otitis media pathogens Haemophilus influenzae, H. parainfluenzae, Moraxella catarrhalis, Pseudomonas aeruginosa, Streptococcus pneumoniae. efficacy these compared each other used clinical practice. Methods: Microscopic pollen analysis physicochemical traits were confirm botanical origin honey samples. antibiotic sensitivity tested disk diffusion assay. Minimum inhibitory concentrations determined using microdilution A 24 h immature biofilm eradication test performed crystal violet checkerboard titration method. DNA release damaged bacterial cells measured membrane degradation Results: Lavender oil displayed more potent activity However, honey–essential showed higher inhibition rates eradication, P. aeruginosa being most resistant bacterium. combined use resulted degree shorter time, synergistic effect proven titration. Conclusions: combination or shown be effective formed M. S.

Language: Английский

Citations

0
Application of gamma irradiation and high‐pressure processing on physicochemical, antioxidant and microbiological properties of natural honey DOI Open Access

Nantarat Na Nakornpanom,

Arusa Chaovanalikit,

Jenjira Thongart

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract BACKGROUND Gamma irradiation (0, 2, 4, 8 kGy) and high‐pressure processing (HPP at 400 600 MPa for 10 20 min) were applied to improve the physicochemical antioxidant properties safety of natural polyfloral honey compared heat treatment (60 °C). RESULTS Although enhanced activities, it considerably changed color honey. In contrast, gamma HPP able retain Heat led a slight increase in hydroxymethylfurfural (22.3 19.7–23.0 mg kg −1 ), whereas was significantly reduced after (9.1–13 ). kGy found enhance phenolic content, flavonoid content 83.10 49.34 GAE 100 g , 4.78 2.53 QE 88.75% 82.56%, respectively. comparison, (600 MPa/20 exhibited less promotion these health benefits 40.81 1.80 65.40%. The study also that inoculated Salmonella spp. entirely controlled by treatment, doses above 4 min. CONCLUSION min are recommended due their efficiency improving qualities, microbial By comparing nonthermal methods with traditional this offers valuable insights into optimal preservation strategies maintaining quality while minimizing undesirable changes. © 2025 Society Chemical Industry.

Language: Английский

Citations

0
Brazilian Organic Honeydew Reduces In Vitro and In Vivo Periodontal Disease-Related Subgingival Biofilm DOI Creative Commons
Diego Romário Silva, Marcelo Franchin, Bruno Bueno‐Silva

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 997 - 997

Published: March 14, 2025

We investigated the antimicrobial properties and effects on bone resorption of Brazilian organic honeydew (OHD) from Bracatinga tree (Mimosa scabrella Benth.), a rare honey certified with Denomination Origin, using periodontal disease model. Antibiofilm activity was assessed subgingival biofilm adhered to Calgary device. Biofilms were treated OHD, chlorhexidine (0.12%), or vehicle twice daily for 1 min starting day 3, at concentrations 2× 10× minimum inhibitory concentration (MIC). employed ligature-induced chronic model challenged it Porphyromonas gingivalis in C57BL/6 mice. The chemical profile OHD analyzed LC-ESI-IT-MS/MS. Results evaluated by measuring loss microbial composition ligature through DNA-DNA hybridization. demonstrated significant against P. (MIC 4%, MBC 6%) reduced viability 80% vitro. In vivo, decreased populations associated disease. Chemical analysis identified seven compounds including five flavonoids two lignans. This Atlantic Forest exhibits strong potential as functional food oral health, offering promising alternative control prevention

Language: Английский

Citations

0
Health benefits of honey: A critical review on the homology of medicine and food in traditional and modern contexts DOI Creative Commons
Mohamed G. Sharaf El-Din, Abdelaziz F. S. Farrag, Liming Wu

et al.

Journal of Traditional Chinese Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Current State and Advances in Antimicrobial Strategies for Burn Wound Dressings: From Metal-Based Antimicrobials and Natural Bioactive Agents to Future Perspectives DOI Open Access
Andrea Osmokrović, Jasmina Stojkovska, Tanja Krunić

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4381 - 4381

Published: May 5, 2025

Burn wounds represent a complex clinical challenge, primarily due to their high susceptibility infections and the frequent formation of biofilm, which significantly hinder healing process. Therefore, effective infection prevention management are critical components burn wound care. This review provides comprehensive overview current emerging antimicrobial strategies in management, with particular focus on alternative approaches conventional antiseptics antibiotics. manuscript highlights role metals metal-based agents, including silver, zinc oxide, copper compounds, alongside plant-derived bioactive substances such as aloe vera, marigold, turmeric. Additionally, potential peptides probiotics innovative therapeutic options is explored, emphasizing antimicrobial, anti-inflammatory, pro-healing properties. Finally, this presents an analysis recent patents field care, offering insights into trends future directions development advanced dressings. By addressing both established novel strategies, aims provide valuable resource for clinicians, researchers, innovators seeking improve outcomes management.

Language: Английский

Citations

0
Honeydew Honey as a Reservoir of Bacteria with Antibacterial and Probiotic Properties DOI Creative Commons
Dorota Grabek-Lejko,

Mariusz Worek

Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 855 - 855

Published: Sept. 6, 2024

The purpose of this study was to isolate, identify, and evaluate the antibacterial probiotic potential bacteria from honeydew honey collected in Poland. Isolates (189 colonies 10 samples) were evaluated for their antimicrobial activity against

Language: Английский

Citations

2
Propolis extract and Hermetia illucens larval proteins synergistically inhibit the growth of Aspergillus niger DOI
Qingzhi Ding, Zheng Yuan, Yongqi Zhu

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104661 - 104661

Published: July 5, 2024

Language: Английский

Citations

1
HERBAL-INFUSED EGYPTIAN BEE HONEY: A BOON OR A CURSE? ITS IMPACT ON SENSORIAL, PHYSICOCHEMICAL, & ANTIBACTERIAL PROPERTIES DOI Open Access

Ghada M. El-Kherbawy,

Magda Hassan,

Asmaa Abd Alla

et al.

Uludağ Arıcılık Dergisi, Journal Year: 2024, Volume and Issue: 24(2), P. 337 - 355

Published: Oct. 11, 2024

Herbal honey mixture remedies are well known for their therapeutic benefits in traditional medicine. This research aspired to assess melissopalynological, sensorial, physicochemical, & antibacterial activity three types of (clover, citrus, and cucurbits) mixtures with black seed, date palm pollen, wheat germ at 1, 2.5, 5%. The best were chosen according overall acceptability. Consumer’s preference was given raw honey. However, some as acceptable Melissopalynological analysis lower glucose level compared fructose evidences that honeys natural. Infusing herbs different caused higher electrical conductivity, free acidity, ash, H2O2, HMF levels, pH. Type herb may affect the physicochemical characteristics ways. Honey whether used alone or combination herbs, demonstrated same significant effect Staphylococcus aureus MRSA. Inhibition zones its than control Pseudomonas aeruginosa. Most undiluted samples created larger bacterial inhibition 50% diluted counterparts. Depending on type honey, additive concentration, infusing could alter chemical, physical, qualities.

Language: Английский

Citations

0
Comparison of the Physicochemical Properties, Microbial Communities, and Hydrocarbon Composition of Honeys Produced by Different Apis Species DOI Creative Commons
Guozhi Zhang,

Yao Liu,

Yaling Luo

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3753 - 3753

Published: Nov. 23, 2024

The chemical composition and quality of honey are influenced by its botanical, geographic, entomological origins, as well climatic conditions. In this study, the physicochemical characteristics, microbial communities, hydrocarbon compounds produced Apis mellifera, cerana, laboriosa, dorsata, florea were elucidated. profile exhibited significant differences across species, including moisture content (18.27–23.66%), fructose (33.79–38.70%), maltose (1.10–1.93%), electrical conductivity (0.37–0.74 mS/cm), pH (3.36–3.72), diastase activity (4.50–29.97 number), color (37.90–102.47 mm). Microbial analysis revealed a abundance lactic acid bacteria, particularly Apilactobacillus genus in A. laboriosa Lactobacillus honey, indicating probiotic potential. Chemometric methods, principal component analysis, hierarchical cluster orthogonal partial least squares discriminant (OPLS-DA) used to classify samples based on 12 beeswax-derived hydrocarbons. OPLS-DA model demonstrated 100% accuracy predicting origin that specific hydrocarbons reliable markers for classification.

Language: Английский

Citations

0