Journal of Advanced Research,
Journal Year:
2023,
Volume and Issue:
52, P. 59 - 72
Published: Jan. 11, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
with
obesity
seriously
threats
public
health.
Our
previous
studies
showed
that
dark
tea
had
more
potential
on
regulating
lipid
metabolism
than
other
teas,
and
theabrownin
(TB)
was
considered
to
be
a
main
contributor
the
bioactivity
of
tea.This
in
vivo
study
aims
reveal
effects
molecular
mechanisms
TB
NAFLD
obesity,
role
gut-liver
axis
is
explored.The
histopathological
examinations,
biochemical
tests,
nuclear
magnetic
resonance
were
applied
evaluate
obesity.
The
untargeted
metabolomics
used
find
key
molecule
for
further
exploration
mechanisms.
16S
rRNA
gene
sequencing
assess
changes
gut
microbiota.
antibiotic
cocktail
fecal
microbiota
transplant
clarify
microbiota.TB
markedly
reduced
body
weight
gain
(67.01%),
fat
rate
(62.81%),
hepatic
TG
level
(51.35%)
preventive
experiment.
Especially,
decreased
(32.16%),
(42.56%),
(42.86%)
therapeutic
action
could
improvement
acid
oxidation,
lipolysis,
oxidative
stress
via
regulation
serotonin-related
signaling
pathways.
Also,
increased
abundance
microbiota,
such
as
Akkermansia,
Bacteroides
Parabacteroides.
Antibiotics-induced
bacterial
dysbiosis
disrupted
pathways
liver,
whereas
beneficial
target
proteins
regained
restoration
microbiota.We
has
by
serotonin
related
through
Furthermore,
co-contribute
alleviating
promising
medicine
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(13), P. 3019 - 3019
Published: July 3, 2023
Dietary
plant
polysaccharides,
one
of
the
main
sources
natural
possess
significant
cancer
prevention
activity
and
potential
development
value
in
food
medicine
fields.
The
anti-tumor
mechanisms
polysaccharides
are
mainly
elaborated
from
three
perspectives:
enhancing
immunoregulation,
inhibiting
tumor
cell
growth
invasion
metastasis.
immune
system
plays
a
key
role
progression,
immunomodulation
is
considered
pathway
for
or
treatment.
Although
much
progress
has
been
made
revealing
relationship
between
huge
challenges
still
met
research
polysaccharides.
Results
suggest
that
certain
polysaccharide
types
glycosidic
linkage
forms
significantly
affect
biological
immunoregulation.
At
present,
vitro
effects
immunoregulation
dietary
widely
reported
articles;
however,
vivo
deserving
further
investigation.
In
this
paper,
aspects
behind
polysaccharides'
achieved
through
cells
mediatory
gut
microbiota
systematically
summarized,
with
aim
encouraging
future
on
use
prevention.
