Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117659 - 117659
Published: Nov. 1, 2024
Language: Английский
Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156436 - 156436
Published: Jan. 1, 2025
Language: Английский
Citations
7
Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 1, 2024
Over decades, the source-function relationships of bioactive polysaccharides have been progressively investigated, however, it is still unclear how a defined structure may conduce to bioactivities polysaccharides. To explore structure-function relationship fungus polysaccharides, we employed dextran sulfate sodium (DSS)‐induced colitis mouse model compare anti-inflammatory activity two from Dictyophora indusiata (DIP) and Tremella fuciformis (TFP), which exhibit distinct glycosidic linkages. The structures DIP TFP were characterized through molecular weight detection, morphology analysis, methylation NMR analysis. Subsequently, DSS-induced assess efficacy TFP. symptoms, histological morphology, intestinal inflammatory cytokines, composition function gut microbiota before after treatment in mice also investigated. DIP, l,3-β-D-glucan with 1,4-β 1,6-β-D-Glcp as branched chains, exhibited superior therapeutic effect than that consisted linear 1,3-α-D-mannose backbone D-xylose L-fucose side chains. Both relieved dependent manner. Furthermore, metagenomics showed could partially reverse bacterial mice. Glycoside Hydrolase 1 (GH1) GH3 shown cleave glucose linkages while GH92 GH29 likely active on α-1,3-linked mannose bonds residues Our findings highlight pivotal role activities would promote design discovery designated be used functional foods and/or therapeutics.
Language: Английский
Citations
16
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155492 - 155492
Published: Feb. 28, 2024
Language: Английский
Citations
16
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132807 - 132807
Published: May 31, 2024
Language: Английский
Citations
14
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: March 7, 2025
Recent studies have highlighted the prebiotic potential of natural plant polysaccharides, demonstrating their role in promoting beneficial gut microbiota and improving health. However, research on digestive properties activities Imperatae Rhizoma Polysaccharides (IRPs) remains limited. This study investigated fresh as object. After processing, dry carbonized were prepared. Three polysaccharides from fresh, dry, extracted with traditional hot water. And another polysaccharide was obtained by cold water extraction . Total four IRPs named: IRPs-F, IRPs-D, IRPs-C, IRPs-J. evaluated activity derived roots thatch, resistance to digestion, ability promote probiotic growth, enhancement short-chain fatty acid (SCFA) production. The final results show that exhibit strong digestion IRPs-F growth probiotics, making it a promising candidate for functional foods aimed at intestinal health, immune regulation, metabolic benefits. is highly relevant food microbiology holds significant application health sectors.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138855 - 138855
Published: Dec. 1, 2024
Plant-derived bioactive polysaccharides (PDBPs), versatile polymers originating from various botanical sources, exhibit a spectrum of biological functionalities crucial for human health. This review delves into the multifaceted roles these compounds, elucidating their immune-boosting properties, antioxidant prowess, anti-inflammatory capabilities, and contributions to gut Amidst pivotal roles, efficiency PDBPs delivery bioavailability in system stands as central determinant efficacy utilization. paper extensively systematically examines diverse activities, such immunomodulatory effects, mechanisms like microencapsulation, promising applications within realms both food (functional foods nutraceuticals) pharmaceutical (antimicrobial agents drugs) sectors. Additionally, it offers comprehensive overview classification, structural diversity polysaccharides, highlighting identification techniques rheological considerations. Moreover, addresses critical safety regulatory concerns alongside global legislation about plant envisaging broader landscape Through this synthesis, we aim underscore holistic significance potential revolutionize nutritional therapeutic paradigms.
Language: Английский
Citations
7
Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 7, P. 100526 - 100526
Published: June 1, 2024
Functional polysaccharides are characterized by functional and structural biomolecules, which play a dual role, both as nutrient molecules providing energy signalling involved in intercellular communications. There increasing evidences showing that possess beneficial effects for treating chronic diseases, such cancer, cardiovascular disease, etc, but its mechanism of action remains imprecision. Additionally, due to the limitations precision detection methods complexity their structures, metabolic kinetics behaviours or bioavailability polysaccharides, interaction between it entering systemic circulation target cells have been conundrum faced researcher. This review summarized latest advances efficacy diseases structure-activity relationship, absorption behaviours, specific cellular receptors so understand mechanisms bioactivities. is expected provide new insights paves way application.
Language: Английский
Citations
6
Oncogene, Journal Year: 2023, Volume and Issue: 43(2), P. 77 - 91
Published: Dec. 11, 2023
Gastrointestinal (GI) cancer is a formidable malignancy with significant morbidity and mortality rates. Recent studies have shed light on the complex interplay between nervous system GI system, influencing various aspects of tumorigenesis, such as malignance cells, conformation tumor microenvironment (TME), resistance to chemotherapies. The discussion in this review first focused exploring intricate details biological function development tract progression tumors within it. Meanwhile, cell-originated feedback regulation revealed play crucial role growth nerve cells tissues. This interaction vital for understanding relationship oncogenesis. Additionally, study identified components TME that possess influence occurrence cancer, including microbiota, immune fibroblasts. Moreover, we highlighted transformation non-neuronal neuronal during progression, inspiring strategies system-guided anti-tumor drugs. By further elucidating deep mechanism neuroregulatory signals intervention, underlined potential these targeted drugs translating into effective therapies treatment. In summary, provides an overview mechanisms neuromodulation explores therapeutic opportunities, providing insights management cancers.
Language: Английский
Citations
12
Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e31514 - e31514
Published: May 1, 2024
The gastrointestinal tract is an important part of the human immune system. gut microbiome, which constitutes a major component tract, plays crucial role in maintaining normal physiological functions and influences development, diagnosis, immunotherapy colorectal cancer (CRC). Natural polysaccharides can be extracted from animals, plants, traditional Chinese medicines. They serve as essential energy source for promoting probiotic proliferation regulating intestinal microecological balance. Moreover, exhibit anti-tumor effects due to their regulatory low toxicity. This review focuses on discussing these CRC, along with improving microbiome dysbiosis tumor microenvironment, providing evidence effective therapeutic strategies against CRC.
Language: Английский
Citations
4
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 23, 2024
Introduction Ephedra sinica polysaccharide (ESP) exerts substantial therapeutic effects on rheumatoid arthritis (RA). However, the mechanism through which ESP intervenes in RA remains unclear. A close correlation has been observed between enzymes and derivatives gut microbiota inflammatory immune response RA. Methods type II collagen-induced (CIA) mice model was treated with polysaccharide. The effect of evaluated. anti-inflammatory cartilage-protective were also Additionally, metagenomic sequencing performed to identify changes carbohydrate-active resistance genes ESP-treated CIA mice. Liquid chromatography-mass spectrometry gas observe levels serum metabolites short-chain fatty acids gut. Spearman’s correlational analysis revealed a among microbiota, antibiotic-resistance genes, microbiota-derived metabolites. Results treatment significantly reduced inflammation cartilage damage It decreased pro-inflammatory cytokines interleukin (IL)-6, IL-1-β protected intestinal mucosal epithelial barrier, inhibiting cell infiltration damage. Here, TLR4, MyD88, TRAF6 synovium, inhibited p65 expression pp65 phosphorylation NF-κB signaling pathway, blocked histone deacetylase (HDAC1 HDAC2) signals. influenced structure, microbial enzymes, related genes. increased L-tyrosine, sn-glycero-3-phosphocholine, octadecanoic acid, N-oleoyl taurine, N-palmitoyl taurine Conclusion exhibited an inhibitory Its action may be ability effectively reduce levels, protect regulate interaction systems abnormal local microbiota. Accordingly, homeostasis maintained inhibition fibroblast-like synoviocyte (FLS) proliferation HDAC/TLR4/NF-κB pathway mediated, thereby contributing its immune-modulating effects.
Language: Английский
Citations
4