Drug Design Development and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 201 - 218
Published: Jan. 1, 2025
Purpose:
Phytosome
technology,
an
advanced
lipid-based
delivery
system,
offers
a
promising
solution
for
enhancing
the
bioavailability
and
therapeutic
efficacy
of
secondary
metabolites,
particularly
in
cancer
treatment.
These
such
as
flavonoids,
terpenoids,
alkaloids,
possess
significant
anticancer
potential
but
are
often
limited
by
poor
solubility
low
absorption.
This
review
aims
to
investigate
how
phytosome
encapsulation
improves
pharmacokinetic
profiles
effectiveness
these
bioactive
compounds.
Patients
Methods:
comprehensive
is
based
on
analysis
recent
literature
retrieved
from
PubMed,
Scopus,
ScienceDirect
databases.
It
focuses
findings
preclinical
vitro
studies
that
examine
enhancements
provided
technology
when
applied
metabolites.
Results:
Phytosome-encapsulated
metabolites
exhibit
significantly
improved
solubility,
absorption,
distribution,
cellular
uptake
compared
non-encapsulated
forms.
enhanced
facilitates
more
effective
inhibition
pathways,
including
NF-κB
PI3K/AKT,
leading
increased
models.
Conclusion:
has
demonstrated
its
overcome
challenges,
resulting
safer
options
highlights
phytosome-based
formulations
novel
approach
therapy,
supporting
further
development
preclinical,
vitro,
clinical
applications.
Keywords:
phytosome,
cancer,
Critical Reviews in Food Science and Nutrition,
Journal Year:
2023,
Volume and Issue:
unknown, P. 1 - 22
Published: July 10, 2023
Flavonoid
compounds
exhibit
a
wide
range
of
health
benefits
as
plant-derived
dietary
components.
Typically,
co-consumed
with
the
food
matrix,they
must
be
released
from
matrix
and
converted
into
an
absorbable
form
(bioaccessibility)
before
reaching
small
intestine,
where
they
are
eventually
absorbed
transferred
bloodstream
(bioavailability)
to
exert
their
biological
activity.
However,
large
number
studies
have
revealed
functions
individual
flavonoid
in
different
experimental
models,
ignoring
more
complex
but
common
relationships
established
diet.
Besides,
it
has
been
appreciated
that
gut
microbiome
plays
crucial
role
metabolism
flavonoids
substrates,
thereby
having
significant
impact
on
interactions,
much
progress
still
needs
made
this
area.
Therefore,
review
intends
comprehensively
investigate
interactions
between
matrices,
including
lipids,
proteins,
carbohydrates
minerals,
effects
nutritional
properties
matrices
bioaccessibility
bioavailability
compounds.
Furthermore,
interaction
also
discussed.
HIGHLIGHTSFlavonoids
able
bind
nutrients
through
covalent
or
non-covalent
bonds.Flavonoids
affect
digestion
absorption
minerals
(bioaccessibility).Lipids,
proteins
may
favorably
flavonoids.Improved
intestinal
flora
improve
bioavailability.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(6), P. 636 - 636
Published: May 24, 2024
Legumes,
including
beans,
peas,
chickpeas,
and
lentils,
are
cultivated
worldwide
serve
as
important
components
of
a
balanced
nutritious
diet.
Each
legume
variety
contains
unique
levels
protein,
starch,
fiber,
lipids,
minerals,
vitamins,
with
potential
applications
in
various
industries.
By-products
such
hulls,
rich
bioactive
compounds,
offer
promise
for
value-added
utilization
health-focused
product
development.
Various
extraction
methods
employed
to
enhance
protein
rates
from
by-products,
finding
foods
meat
analogs,
breads,
desserts.
Moreover,
essential
fatty
acids,
carotenoids,
tocols,
polyphenols
abundant
several
residual
fractions
legumes.
These
classes
linked
reduced
incidence
cardiovascular
diseases,
chronic
inflammation,
some
cancers,
obesity,
type
2
diabetes,
among
other
relevant
health
conditions.
The
present
contribution
provides
comprehensive
review
the
nutritional
composition
major
legumes
their
by-products.
Additionally,
bioaccessibility
bioavailability
aspects
consumption,
well
vitro
vivo
evidence
effects
addressed.
Food Hydrocolloids,
Journal Year:
2024,
Volume and Issue:
156, P. 110262 - 110262
Published: June 5, 2024
Poor
aqueous
solubility
and
low
stability
are
major
problems
hindering
curcumin
exerting
potent
physiological
activity.
To
overcome
these
challenges,
this
study
fabricated
zein-succinic
acid
modified
cyclodextrin
(SACD)
nanofibers
using
the
electrospinning
technology.
By
optimising
proportion
of
SACD
in
nanofibers,
homogenous
cylindrical
fibers
with
a
uniform
size
distribution
could
be
observed.
The
maximum
loading
capacity
optimized
for
was
ca.
35.7
mg/g,
as
demonstrated
by
X-ray
diffraction
differential
scanning.
No
cytotoxicity
observed
any
Zein/SACD
curcumin-loaded
(Cur-Zein/SACD)
nanofibers.
Cur-Zein/SACD
significantly
improved
under
conditions
mimicking
gastrointestinal
environments
common
heat
sterilization
processes.
In
digestion
study,
less
than
18%
released
simulated
upper
digestive
tract
conditions,
suggesting
most
drug
cargo
is
able
to
reach
lower
utilized
gut
microbiota.
This
suggests
that
highly
effective
strategy
promoting
encapsulation,
stabilization
delivery
bioactive
compounds,
showing
potential
food,
pharmaceutical,
cosmetic
products.
Food Chemistry,
Journal Year:
2023,
Volume and Issue:
435, P. 137581 - 137581
Published: Sept. 23, 2023
Chestnut
(Castanea
sativa)
shells
(CS)
are
an
undervalued
antioxidant-rich
by-product.
This
study
explores
the
impact
of
in-vitro
digestion
on
bioaccessibility,
bioactivity,
and
metabolic
profile
CS
extract
prepared
by
Supercritical
Fluid
Extraction,
aiming
its
valorization
for
nutraceutical
applications.
The
results
demonstrated
significantly
(p
<
0.05)
lower
phenolic
concentrations
retained
after
(38.57
µg
gallic
acid
equivalents/mg
dry
weight
(DW)),
reaching
30%
bioaccessibility.
showed
antioxidant/antiradical,
hypoglycemic,
neuroprotective
properties
digestion,
along
with
upmodulating
effects
antioxidant
enzymes
activities
protection
against
lipid
peroxidation.
screened
LC-ESI-LTQ-Orbitrap-MS
proved
biotransformation
complex
acids,
flavonoids,
tannins
present
in
undigested
(45.78
µg/mg
DW
total
concentration)
into
hydroxybenzoic,
phenylpropanoic,
phenylacetic
acids
upon
(35.54
DW).
These
findings
sustain
as
a
promising
ingredient,
delivering
polyphenols
proven
bioactivity
even
digestion.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2023,
Volume and Issue:
64(33), P. 12702 - 12719
Published: Sept. 13, 2023
Novel,
innovative
approaches
like
edible
gels
(hydrogels
and
oleogels)
are
important
food
materials
with
great
scientific
interest
due
to
their
positive
impacts
on
structural
functional
foods
other
unique
properties.
Biopolymers
(protein,
starch
polysaccharides)
can
be
excellent
cost-effective
for
the
formed
gels.
Recently,
natural
gums,
although
also
as
biopolymers,
preferred
additives
further
improve
textural
properties
of
gels,
which
have
received
extensive
attention.
However,
these
studies
not
been
outlined
in
previous
reviews.
In
this
review,
we
highlighted
advantages
gums
construct
Moreover,
various
roles
(including
electrostatic
or
covalent
interactions)
regulation
gel
(solvent-holding
rheological
properties)
highlighted.
Finally,
use
stability
targeted
delivery
phytochemicals
application
systems
summarized.
The
information
covered
article
may
useful
design
that
better
meet
personalized
needs
people.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1712 - 1712
Published: Jan. 30, 2024
The
cutting-edge
field
of
nanomedicine
combines
the
power
medicinal
plants
with
nanotechnology
to
create
advanced
scaffolds
that
boast
improved
bioavailability,
biodistribution,
and
controlled
release.
In
an
innovative
approach
performant
herb
nanoproducts,
