In
the
pursuit
of
optimal
delivery
hydrophobic
agents
such
as
curcumin,
role
lipid
composition
in
efficacy
nanostructured
carriers
is
gaining
significant
attention.
This
study
aimed
to
investigate
effects
cocoa
butter
(0–10
wt%)
and
medium
chain
triglycerides
mass
ratios
on
processing
stability,
crystallization,
polymorphism
transition,
supersaturation,
encapsulation,
vitro
digestion
curcumin-loaded
(Cur-NLCs).
TEM
analysis
showed
that
spherical
Cur-NLCs
exhibited
larger
average
particle
size
with
increase
content.
Differential
scanning
calorimetry
X-ray
diffraction
revealed
crystallinity
thickness
solid
shells
decreased
liquid
The
obtained
remained
stable
under
various
conditions:
thermal
treatments
(25,
37,
60,
121
°C),
varied
ionic
strengths
(50–500
mM),
pH
changes
(2.0–6.0),
centrifugation
at
15000
rpm/min,
60-days
storage.
Furthermore,
high
supersaturation
(1862.61–2328.45%)
than
nanoemulsion
(1488.56%)
nanoparticles
(1635.41%).
addition,
prepared
bioaccessibility
(79.42–91.77%)
along
a
controlled
release
curcumin.
provides
guidelines
prepare
tailored
physicochemical,
functional
properties
deliver
bioactive
substances,
nutraceuticals
pharmaceuticals.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(10), P. 5348 - 5357
Published: Feb. 27, 2024
Lutein
is
a
high-value
tetraterpenoid
carotenoid
that
widely
used
in
feed,
cosmetics,
food,
and
drugs.
Microbial
synthesis
of
lutein
an
important
method
for
green
sustainable
production,
serving
as
alternative
to
plant
extraction
methods.
However,
inadequate
precursor
supply
low
catalytic
efficiency
key
pathway
enzymes
are
the
main
reasons
efficacy
microbial
lutein.
In
this
study,
some
strategies,
such
enhancing
MVA
localizing
α-carotene
synthase
OluLCY
within
subcellular
organelles
Yarrowia
lipolytica,
were
adopted
enhance
α-carotene,
which
resulted
10.50-fold
increase
titer,
reaching
38.50
mg/L.
Subsequently,
by
improving
hydroxylase
activity
with
truncated
N-terminal
transport
peptide
locating
hydroxylases
organelles,
final
strain
L9
producing
75.25
mg/L
was
obtained.
Eventually,
titer
675.40
(6.13
mg/g
DCW)
achieved
5
L
bioreactor
adding
antioxidant
2,6-ditert-butyl-4-methylphenol.
This
study
realizes
de
novo
Y.
lipolytica
first
time
achieves
highest
reported
so
far.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
Abstract
The
complex
composition
of
traditional
Chinese
medicines
(TCMs)
has
posed
challenges
for
in‐depth
study
and
global
application,
despite
their
abundance
bioactive
compounds
that
make
them
valuable
resources
disease
treatment.
To
overcome
these
obstacles,
it
is
essential
to
modernize
TCMs
by
focusing
on
precise
This
involves
elucidating
the
structure‐activity
relationships
within
compositions,
ensuring
accurate
in
vivo
delivery,
monitoring
delivery
process.
review
discusses
research
progress
precision
treatment
from
three
perspectives:
spatial
multi‐omics
technology
therapeutic
activity,
carrier
systems
medical
imaging
visualizing
aim
establish
a
novel
paradigm
advances
therapy
TCMs.
LWT,
Journal Year:
2024,
Volume and Issue:
194, P. 115799 - 115799
Published: Jan. 30, 2024
Oil
phases
with
different
chain
lengths
and
saturations
were
used
to
make
mandarin
peel
pectin
(MPP)
emulsions
without
lutein
loading.
The
outcomes
demonstrated
that
the
emulsifying,
digesting
characteristics
bioaccessibility
of
MPP
emulsion
related
addition
also
oil
phase
species.
After
addition,
apparent
viscosity
interfacial
tension
dramatically
decreased.
made
from
medium-chain
triglyceride
(MCT)
displayed
higher
absolute
zeta
potential,
free
fatty
acid
release,
bioaccessibility,
while
those
long-chain
(LCT)
(palm
oil,
corn
olive
oil)
had
volume
average
particle
size
tension.
findings
offered
a
theoretical
foundation
for
effective
delivery
release
by
emulsion.
Foods,
Journal Year:
2023,
Volume and Issue:
12(16), P. 2999 - 2999
Published: Aug. 9, 2023
Bioactive
substances
exhibit
various
physiological
activities-such
as
antimicrobial,
antioxidant,
and
anticancer
activities-and
have
great
potential
for
application
in
food,
pharmaceuticals,
nutraceuticals.
However,
the
low
solubility,
chemical
instability,
bioavailability
of
bioactive
limit
their
food
industry.
Using
nanotechnology
to
prepare
protein
nanoparticles
encapsulate
deliver
active
is
a
promising
approach
due
abundance,
biocompatibility,
biodegradability
proteins.
Common
protein-based
nanocarriers
include
nano-emulsions,
nano-gels,
nanoparticles,
nano
complexes.
In
this
review,
we
give
an
overview
nanoparticle
fabrication
methods,
highlighting
pros
cons.
Additionally,
discuss
applications
current
issues
regarding
utilization
Finally,
provide
perspectives
on
future
development
directions,
with
focus
classifying
functional
properties.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2024,
Volume and Issue:
23(6)
Published: Oct. 22, 2024
Abstract
The
health
benefits
of
bioactive
compounds
are
dependent
on
the
amount
intake
as
well
these
that
become
bioavailable
and
bioaccessible.
Various
systems
have
been
developed
to
deliver
increase
bioaccessibility
compounds.
This
review
explores
impact
gelled
(oleogels,
bigels,
emulgels,
emulsions,
hydrogels,
hydrogel
beads),
micro‐
(gels,
particles,
spheres,
capsules,
solid
lipid
microparticles)
nanoencapsulated
(nanoparticles,
nanoparticles,
nanostructured
carriers,
nanoemulsions,
liposomes,
nanoliposomes)
digestibility
bioavailability
lipophilic
hydrophilic
bioactives.
Structurant
molecules,
oil
type,
antioxidants,
emulsifiers,
coatings
in
delivery
with
promising
potential
food
applications
critically
discussed.
release
bio‐accessibility
influenced
by
various
factors,
such
type
concentration
gelators,
gelator‐to‐oil
ratio,
antioxidant,
network
system,
its
hydrophobicity.
stability,
bioaccessibility,
controlled
bioactives
were
improved
structured
emulsions.
Several
variables,
including
wall
material,
oil/water
ratios,
encapsulation
process,
pH
conditions,
can
affect
microencapsulated
systems.
Factors
like
coating
core‐to‐wall
ratio
stability
core
components.
encapsulating
technology,
nature
nanomaterials
all
an
Nanoliposomes
provide
enhanced
absorption.
In
general,
encapsulated
shown
great
improving
distribution
availability
