Drug Design Development and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 201 - 218
Published: Jan. 1, 2025
Purpose:
Phytosome
technology,
an
advanced
lipid-based
delivery
system,
offers
a
promising
solution
for
enhancing
the
bioavailability
and
therapeutic
efficacy
of
secondary
metabolites,
particularly
in
cancer
treatment.
These
such
as
flavonoids,
terpenoids,
alkaloids,
possess
significant
anticancer
potential
but
are
often
limited
by
poor
solubility
low
absorption.
This
review
aims
to
investigate
how
phytosome
encapsulation
improves
pharmacokinetic
profiles
effectiveness
these
bioactive
compounds.
Patients
Methods:
comprehensive
is
based
on
analysis
recent
literature
retrieved
from
PubMed,
Scopus,
ScienceDirect
databases.
It
focuses
findings
preclinical
vitro
studies
that
examine
enhancements
provided
technology
when
applied
metabolites.
Results:
Phytosome-encapsulated
metabolites
exhibit
significantly
improved
solubility,
absorption,
distribution,
cellular
uptake
compared
non-encapsulated
forms.
enhanced
facilitates
more
effective
inhibition
pathways,
including
NF-κB
PI3K/AKT,
leading
increased
models.
Conclusion:
has
demonstrated
its
overcome
challenges,
resulting
safer
options
highlights
phytosome-based
formulations
novel
approach
therapy,
supporting
further
development
preclinical,
vitro,
clinical
applications.
Keywords:
phytosome,
cancer,
Foods,
Journal Year:
2024,
Volume and Issue:
13(8), P. 1223 - 1223
Published: April 17, 2024
Protein
is
composed
of
peptides,
essential
nutrients
for
human
survival
and
health,
the
easy
absorption
peptides
further
promotes
health.
According
to
source
protein,
it
can
be
divided
into
plants,
animals,
micro-organisms,
which
have
important
physiological
effects
on
health
body,
especially
in
enhancing
immunity.
The
most
widely
used
raw
materials
are
animal
protein
plant
composition
formed
by
two
a
certain
proportion
called
“double
protein”.
In
recent
years,
China’s
State
Administration
Market
Regulation
has
issued
an
announcement
“Implementation
Rules
Technical
Evaluation
New
Functions
Products
Health
Foods
(Trial)”,
provides
application
conditions
listing
protection
research
development
new
functions
foods.
At
present,
some
researchers
enterprises
begun
pay
attention
potential
proteins
functions.
this
article,
progress
Chinese
food
reviewed
detail,
suggestions
future
put
forward.
Foods,
Journal Year:
2024,
Volume and Issue:
13(15), P. 2453 - 2453
Published: Aug. 2, 2024
The
efficacy
of
many
edible
bioactive
agents
is
limited
by
their
low
water
dispersibility
and
chemical
instability
in
foods,
as
well
poor
bioaccessibility,
absorption,
metabolism
within
the
human
gastrointestinal
tract.
Whey
proteins
are
amphiphilic
molecules
that
can
be
used
to
construct
a
variety
carrier
systems
improve
performance
ingredients.
These
being
food
biomedical
industries
encapsulate,
protect,
deliver
agents.
In
this
article,
we
begin
providing
an
overview
molecular
functional
characteristics
whey
proteins,
then
discuss
interactions
with
various
kinds
ability
building
blocks
assemble
different
discussed,
including
nanoparticles,
hydrogels,
oleogels,
bigels,
nanofibers,
nanotubes,
nanoemulsions.
Moreover,
applications
these
highlighted.
Different
protein-based
carriers
Each
kind
has
its
own
characteristics,
which
make
them
suitable
for
application
needs
foods
other
products.
Previous
studies
suggest
particularly
protecting
chemically
labile
prolonging
release
profiles.
future,
it
likely
pharmaceutical
fields
will
expand.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 1, 2025
Abstract
Macauba
is
an
underexplored
palm
with
significant
potential
for
food‐grade
vegetable
oil
production.
Its
fruits
yield
two
distinct
sources
of
oil,
the
pulp
and
kernel,
each
its
unique
composition,
emerging
as
a
source
high
competitiveness
well‐established
conventional
sources.
Besides
macauba
are
rich
in
essential
nutrients,
including
proteins,
minerals,
vitamins,
dietary
fiber,
phytochemicals,
outstanding
health
benefits.
processing
generates
valuable
co‐products,
epicarp,
kernel
cakes,
endocarp,
which
have
considerable
enhancing
production
chain.
This
review
explores
nutritional
phytochemical
profile
macauba,
benefits,
exploiting
co‐products.
Innovative
extraction
methods
comprehensive
strategy
producing
multiple
products
from
co‐products
also
highlighted
opportunities
to
achieve
sustainable
development
goals
circular
economy
fruit
processing.
Drug Design Development and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 201 - 218
Published: Jan. 1, 2025
Purpose:
Phytosome
technology,
an
advanced
lipid-based
delivery
system,
offers
a
promising
solution
for
enhancing
the
bioavailability
and
therapeutic
efficacy
of
secondary
metabolites,
particularly
in
cancer
treatment.
These
such
as
flavonoids,
terpenoids,
alkaloids,
possess
significant
anticancer
potential
but
are
often
limited
by
poor
solubility
low
absorption.
This
review
aims
to
investigate
how
phytosome
encapsulation
improves
pharmacokinetic
profiles
effectiveness
these
bioactive
compounds.
Patients
Methods:
comprehensive
is
based
on
analysis
recent
literature
retrieved
from
PubMed,
Scopus,
ScienceDirect
databases.
It
focuses
findings
preclinical
vitro
studies
that
examine
enhancements
provided
technology
when
applied
metabolites.
Results:
Phytosome-encapsulated
metabolites
exhibit
significantly
improved
solubility,
absorption,
distribution,
cellular
uptake
compared
non-encapsulated
forms.
enhanced
facilitates
more
effective
inhibition
pathways,
including
NF-κB
PI3K/AKT,
leading
increased
models.
Conclusion:
has
demonstrated
its
overcome
challenges,
resulting
safer
options
highlights
phytosome-based
formulations
novel
approach
therapy,
supporting
further
development
preclinical,
vitro,
clinical
applications.
Keywords:
phytosome,
cancer,
