Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1845 - 1845

Published: Feb. 15, 2023

Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical medicinal sections to promote human health prevent cure different diseases. The most common found nature anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, other sub-classes. impacts of plant phenolics on promoting diseases curing preventing antioxidant effects, antibacterial impacts, cardioprotective anticancer immune system promoting, anti-inflammatory skin protective effects from UV radiation. This work aims provide an overview phenolic as important sources medical application according recently published studies, well some interesting directions future research. keyword searches flavonoids, phenolics, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, secoiridoids were performed by using Web Science, Scopus, Google scholar, PubMed. acids contain a carboxylic acid group addition the basic structure mainly divided into hydroxybenzoic hydroxycinnamic acids. Hydroxybenzoic based C6-C1 skeleton often bound small organic acids, glycosyl moieties, or cell structural components. Common include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, salicylic Hydroxycinnamic C6-C3 also molecules such quinic glucose. main caffeic, p-coumaric, ferulic, sinapic

Language: Английский

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Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling

Molecules, Journal Year: 2022, Volume and Issue: 27(21), P. 7653 - 7653

Published: Nov. 7, 2022

Despite the immense therapeutic advances in field of health sciences, cancer is still to be found among global leading causes morbidity and mortality. Ethnomedicinally, natural bioactive compounds isolated from various plant sources have been used for treatment several types gained notable attention. Ferulic acid, a compound derived seeds, nuts, leaves, fruits, exhibits variety pharmacological effects cancer, including its proapoptotic, cell-cycle-arresting, anti-metastatic, anti-inflammatory activities. This review study presents thorough overview molecular targets cellular signaling pathways modulated by ferulic acid diverse malignancies, showing high potential this phenolic developed as candidate agent novel anticancer therapeutics. In addition, current investigations develop promising synergistic formulations are also discussed.

Language: Английский

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Molecular mechanism of ferulic acid and its derivatives in tumor progression

Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(4), P. 891 - 906

Published: May 18, 2023

Abstract Cancer is a significant disease that poses major threat to human health. The main therapeutic methods for cancer include traditional surgery, radiotherapy, chemotherapy, and new such as targeted therapy immunotherapy, which have been developed rapidly in recent years. Recently, the tumor antitumor effects of active ingredients natural plants attracted extensive attention. Ferulic acid (FA), (3-methoxy-4-hydroxyl cinnamic), with molecular formula C 10 H O 4 , phenolic organic compound found ferulic, angelica, jujube kernel, other Chinese medicinal but also, abundant rice bran, wheat food raw materials. FA has anti-inflammatory, analgesic, anti-radiation, immune-enhancing also shows anticancer activity, it can inhibit occurrence development various malignant tumors, liver cancer, lung colon breast cancer. cause mitochondrial apoptosis by inducing generation intracellular reactive oxygen species (ROS). interfere cell cycle cells, arrest most cells G 0 /G 1 phase, exert an effect autophagy; inhibiting migration, invasion, angiogenesis; synergistically improving efficacy chemotherapy drugs reducing adverse reactions. acts on series extracellular targets involved regulation signaling pathways, including phosphatidylinositol 3 kinase (PI3K)/protein B (AKT), B-cell lymphoma-2 (Bcl-2), protein 53 (P53) pathways pathways. In addition, derivatives nanoliposomes, platforms drug delivery, important regulatory resistance. This paper reviews mechanisms therapies provide theoretical support insight clinical therapy.

Language: Английский

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Pharmacological Evaluation of Acacia nilotica Flower Extract against Helicobacter pylori and Human Hepatocellular Carcinoma In Vitro and In Silico

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(4), P. 237 - 237

Published: April 21, 2023

The resistance of cancer and Helicobacter pylori to several drugs reflects a worldwide problem, it has been the intention numerous researchers overcome this problem. Thus, in study, Acacia nilotica fruits were subjected HPLC analysis detect their phenolic compounds flavonoids. Moreover, A. nilotica‘s anti-H. activity its inhibitory against human hepatocellular carcinoma (HepG-2 cells) reported. Various with different concentrations, such as ferulic acid (5451.04 µg/mL), chlorogenic (4572.26 quercetin (3733.37 rutin (2393.13 gallic (2116.77 cinnamic (69.72 hesperetin (121.39 µg/mL) methyl gallate (140.45 detected. Strong at 31 mm was reported, compared positive control 21.67 inhibition zone. MIC MBC 7.8 µg/mL 15.62 µg/mL, respectively, while 31.25 µg/mL. concentration 25%, 50% 75% reflected H. pylori’s anti-biofilm 70.38%, 82.29% 94.22%, respectively. Good antioxidant properties flower extract documented 15.63, 62.50, 250 1000 causing DPPH scavenging percentages 42.3%, 52.6%, 65.5% 80.6%, IC50 36.74 HepG-2 cell proliferation inhibited (91.26%) using 500 an 176.15 395.30 used normal melanocytes. Molecular docking applied investigate (4HI0) crystal structure determine best binding mode that interacted most energetically sites. indicated proper inhibitor for 4HI0 protein enzyme pylori. A low energy score (−5.58 Kcal/mol) recorded result interaction residue’s SER 139 active site caused by O 29 atom, which important antibacterial activity.

Language: Английский

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Rabdosia rubescens (Hemsl.) H. Hara: A Potent Anti-Tumor Herbal Remedy - Botany, Phytochemistry, and Clinical Breakthroughs

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119200 - 119200

Published: Dec. 3, 2024

Language: Английский

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Natural products targeting macroautophagy signaling in hepatocellular carcinoma therapy: Recent evidence and perspectives

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(3), P. 1623 - 1650

Published: Feb. 1, 2024

Abstract Hepatocellular carcinoma (HCC), presently the second leading cause of global cancer‐related mortality, continues to pose significant challenges in realm medical oncology, impacting both clinical drug selection and mechanistic research. Recent investigations have unveiled autophagy‐related signaling as a promising avenue for HCC treatment. A growing body research has highlighted pivotal role autophagy‐modulating natural products inhibiting progression. In this context, we provide concise overview fundamental autophagy mechanism delineate involvement autophagic pathways development. Additionally, review pertinent studies demonstrating how regulate mitigate HCC. Our findings indicate that exhibit cytotoxic effects through induction excessive autophagy, simultaneously impeding cell proliferation by inhibition, thereby depriving cells essential energy. These been associated with various pathways, including PI3K/AKT, MAPK, AMPK, Wnt/β‐catenin, Beclin‐1, ferroautophagy. results underscore considerable therapeutic potential However, it is important note present study did not establish definitive thresholds or inhibition products. Further domain imperative gain comprehensive insights into dual equipping us better understanding double‐edged sword management.

Language: Английский

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Bioactive Molecules from the Invasive Blue Crab Callinectes sapidus Exoskeleton: Evaluation of Reducing, Radical Scavenging, and Antitumor Activities

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(1), P. 45 - 45

Published: Jan. 17, 2025

In recent years, the invasive Atlantic blue crab (Callinectes sapidus) has increased its spread throughout Mediterranean Sea, threatening native biodiversity and local economies. This study aimed to valorize C. sapidus sampled in Sicily by utilizing exoskeleton as a source of chitosan, astaxanthin, bio-phenolic compounds. These biomolecules were evaluated for their reducing, radical scavenging, antitumor activity. The ferric ion reducing antioxidant power (FRAP) free scavenging activity against 2,2-Diphenyl-1-picrylhydrazyl (DPPH) significantly higher chitosan (3.16 ± 0.10 mg AAE/g 8.1 µmol TE/g). No significant differences observed among tested 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). Both compounds astaxanthin exhibited dose-dependent cytotoxicity on CaCo-2 (IC50 = 12.47 18 µg/mL) HepG2 10.25 1.26 cell lines, while only bio-phenols showed no cytotoxic effect differentiated cells up 20 µg/mL. findings highlight value by-products supporting circular economy, offering sustainable approach managing this species providing bioactive with promising medical nutraceutical applications.

Language: Английский

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Rapid synthesis of ferulic acid-derived lignin coated silver nanoparticles with low cytotoxicity and high antibacterial activity

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134471 - 134471

Published: Aug. 3, 2024

Language: Английский

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Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 38(1), P. 280 - 304

Published: Oct. 23, 2023

Abstract This review focuses on the potential ameliorative effects of polyphenolic compounds derived from human diet hepatic diseases. It discusses molecular mechanisms and recent advancements in clinical applications. Edible polyphenols have been found to play a therapeutic role, particularly liver injury, fibrosis, NAFLD/NASH, HCC. In regulation exhibit anti‐inflammatory antioxidant effects, primarily targeting TGF‐β, NF‐κB/TLR4, PI3K/AKT, Nrf2/HO‐1 signaling pathways. effectively reverse fibrotic process by inhibiting activation stellate cells (HSC). Furthermore, show efficacy against NAFLD/NASH lipid oxidation accumulation, mediated through AMPK, SIRT, PPARγ Moreover, several anti‐HCC activity suppressing tumor cell proliferation metastasis. inhibition involves blocking Akt Wnt signaling, as well epithelial‐mesenchymal transition (EMT). Additionally, trials nutritional evidence support notion that certain can improve disease associated metabolic disorders. However, further fundamental research are warranted validate dietary polyphenols.

Language: Английский

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Growth inhibition and apoptosis induction in hepatocellular carcinoma cells by partially purified nutraceutical proteins from quinoa bran

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106252 - 106252

Published: Feb. 1, 2025

Language: Английский

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