International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6348 - 6348
Published: June 8, 2024
Cancers
are
causing
millions
of
deaths
and
leaving
a
huge
clinical
economic
burden.
High
costs
cancer
drugs
limiting
their
access
to
the
growing
number
cases.
The
development
more
affordable
alternative
therapy
could
reach
patients.
As
gut
microbiota
plays
significant
role
in
treatment
cancer,
microbiome-targeted
has
gained
attention
recent
years.
Dietary
natural
compounds
can
modulate
composition
while
providing
broader
accessible
medicine.
Tea
have
been
shown
anti-cancer
properties
as
well
related
metabolites.
However,
there
is
no
comprehensive
review
that
focuses
on
modulatory
effects
tea
impact
reshaping
metabolic
profiles,
particularly
models.
In
this
review,
different
settings
discussed.
Furthermore,
relationship
between
these
modulated
bacteria
metabolites,
along
with
mechanisms
how
changes
led
intervention
summarized.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2023,
Volume and Issue:
64(31), P. 11321 - 11340
Published: Aug. 16, 2023
As
far
as
health
benefit
is
concerned,
dark
tea
one
of
the
best
beverages
in
world.
Theabrownins
are
major
ingredient
contributing
to
benefits
and
known
"the
soft
gold
tea."
A
growing
body
evidence
indicated
that
theabrownins
macromolecular
pigments
with
reddish-brown
color
mellow
taste,
mainly
derived
from
oxidative
polymerization
polyphenols.
main
active
ingredients
which
brings
multiple
health-promoting
effects
modulating
lipid
metabolism,
reducing
weight
gain,
attenuating
diabetes,
mitigating
NAFLD,
scavenging
ROS,
preventing
tumors.
More
importantly,
it's
their
substantial
generation
microbial
fermentation
endows
much
stronger
hypolipidemic
effect
compared
other
types
tea.
This
review
firstly
summarizes
most
recent
findings
on
preparation,
structural
characteristics,
theabrownins,
emphasizing
underlying
molecular
mechanism,
especially
different
mechanisms
behind
theabrownins-mediated
gut
microbiota
host's
benefits.
Furthermore,
this
points
out
limitations
current
research
potential
future
directions,
hoping
provide
updated
scientific
for
better
theoretical
industrial
utilization.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(15), P. 8506 - 8520
Published: April 3, 2024
The
dysregulation
of
lipid
metabolism
poses
a
significant
health
threat,
necessitating
immediate
dietary
intervention.
Our
previous
research
unveiled
the
prebiotic-like
properties
theabrownin.
This
study
aimed
to
further
investigate
theabrownin-gut
microbiota
interactions
and
their
downstream
effects
on
using
integrated
physiological,
genomic,
metabolomic,
transcriptomic
approaches.
results
demonstrated
that
theabrownin
significantly
ameliorated
dyslipidemia,
hepatic
steatosis,
systemic
inflammation
induced
by
high-fat/high-cholesterol
diet
(HFD).
Moreover,
improved
HFD-induced
gut
dysbiosis
alterations
in
microbiota-derived
metabolites.
Additionally,
detailed
interplay
between
was
revealed.
Analysis
transcriptome
indicated
FoxO
PPAR
signaling
pathways
played
pivotal
roles
response
interactions,
primarily
through
upregulating
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(8), P. 4421 - 4435
Published: Jan. 1, 2024
The
composition
and
metabolites
of
gut
microbiota
play
important
roles
in
improving
insulin
resistance,
hepatic
steatosis,
inflammation
by
theabrownin
from
Fu
Brick
tea.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(19), P. 9632 - 9661
Published: Jan. 1, 2024
Metabolic
syndrome
(MetS)
is
a
disease
condition
incorporating
the
abnormal
accumulation
of
various
metabolic
components,
including
obesity,
insulin
resistance
and
glucose
tolerance,
hypertension,
atherosclerosis,
or
dyslipidemia.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(18), P. 3903 - 3903
Published: Sept. 7, 2023
Tea
is
one
of
the
most
popular
drinks
in
world.
Dark
tea
a
kind
post-fermented
with
unique
sensory
characteristics
that
produced
by
special
fermentation
microorganisms.
It
contains
many
bioactive
substances,
such
as
polyphenols,
theabrownin,
polysaccharides,
etc.,
which
have
been
reported
to
be
beneficial
human
health.
This
paper
reviewed
latest
research
on
dark
tea’s
potential
preventing
and
managing
cancer,
mechanisms
mainly
involved
anti-oxidation,
anti-inflammation,
inhibiting
cancer
cell
proliferation,
inducing
apoptosis,
tumor
metastasis,
regulating
intestinal
flora.
The
purpose
this
review
accumulate
evidence
anti-cancer
effects
tea,
corresponding
limitations
for
prevention
management,
future
prospects,
demanding
questions
about
possible
contributions
an
adjuvant.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(5), P. e26923 - e26923
Published: Feb. 28, 2024
Feeding
on
a
high-fat
diet
(HFD)
results
in
obesity
and
chronic
inflammation,
which
may
have
long-term
effects
neuroinflammation
hippocampal
injury.
Theabrownin,
biologically
active
compound
derived
from
the
microbial
fermentation
of
Qingzhuan
dark
tea,
exhibits
anti-inflammatory
properties
lipid-lowering
effects.
Nevertheless,
its
potential
neuroprotection
has
yet
to
be
investigated.
Consequently,
this
study
aims
investigate
neuroprotective
Theabrownin
extracted
as
well
therapeutic
mechanisms.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
174, P. 116582 - 116582
Published: April 19, 2024
The
aim
of
this
study
was
to
investigate
whether
the
therapeutic
effect
theabrownin
extracted
from
Qingzhuan
tea
(QTB)
on
metabolic
dysfunction-associated
steatosis
liver
disease
(MASLD)
is
related
regulation
intestinal
microbiota
and
its
metabolite
short-chain
fatty
acids
(SCFAs).
Mice
were
divided
into
four
groups
received
normal
diet
(ND),
high-fat
(HFD)
HFD+QTB
(180,
360
mg/kg)
for
8
weeks.
results
showed
that
QTB
significantly
reduced
body
weight
HFD
mice,
ameliorated
lipid
dyslipidemia,
increased
level
SCFAs
in
mice.
16
S
rRNA
relative
abundance
Bacteroides,
Blautia
Lachnoclostridium
their
main
metabolites
acetate
propionate
after
intervention.
Colidextribacter,
Faecalibaculum
Lactobacillus
reduced.
can
also
up-regulate
expression
ATGL,
PPARα,
FFAR2
FFAR3,
inhibit
LXRα,
SREBP-1c,
FAS
HMGCR
genes.
This
makes
it
possible
act
as
a
prebiotic
prevent
MASLD.
