Polysaccharides: The Sweet and Bitter Impacts on Cardiovascular Risk

Polymers, Journal Year: 2025, Volume and Issue: 17(3), P. 405 - 405

Published: Feb. 3, 2025

Cardiovascular risk is a clinical factor that represents the probability of developing cardiovascular diseases (CVDs). This shaped by non-modifiable and modifiable factors, including dietary patterns, which are main lifestyle influencing CVD. Dietary polysaccharides, integral to nutrition, have varying effects on health depending their type source. They include starches, non-starch prebiotic fibers, categorized further into soluble insoluble fibers. Soluble found in oats, legumes, fruits, dissolve water, forming gels help lower serum cholesterol modulate blood glucose levels. Insoluble present whole grains vegetables, aid bowel regularity. The benefits polysaccharides linked ability bind bile acids, reducing levels, production short-chain fatty acids gut microbiota, anti-inflammatory properties. However, not all beneficial; refined starches can lead adverse metabolic effects, chitosan mixed microbiota. review examines dualistic nature highlighting beneficial roles factors potential specific types.

Language: Английский

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Dietary Oligosaccharides Isolated from Coix Seed Mitigate Hyperuricemia through Modulation of Lipid Metabolites and Intestinal Homeostasis

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Hyperuricemia (HUA) is a prevalent metabolic disorder associated with chronic disease, posing significant global health challenges. Coix seed, traditional cereal, has shown therapeutic potential against HUA, oligosaccharides serving as its primary active components. However, the mechanisms of seed in HUA management remain underexplored. In this study, novel oligosaccharide was isolated from (CSO) through enzymatic hydrolysis and column chromatography. Structural analysis revealed that CSO primarily composed glucose, backbone →4)-β-Glcp-(1→ linkages. exhibited hypouricemic effects both adenosine-induced HK-2 cells mice by inhibiting XOD activity regulating urate transporter expression. Furthermore, restored lipid imbalances, particularly PS PC, modulated gut microbiota increasing Ruminococcus, Akkermansia, Lachnospiraceae abundance to alleviate HUA-related systemic disturbances. Importantly, alleviated HUA-induced renal injury downregulating IL-6/JAK2/STAT3 signaling pathway. This study provided meaningful evidence supporting effect on offered new directions for natural interventions health.

Language: Английский

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Sodium alginate improves lipid disruption and alters the composition of the gut microbiota in farnesoid X receptor-null mice

International Journal of Food Sciences and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 2, 2025

Seaweed-derived dietary fibre sodium alginate (SA) has been shown to present with health benefits in food-derived disease models. To determine whether SA improves the rather than merely suppressing its progression, we assessed effects using farnesoid X receptor (FXR)-deficient mice provide a model of advanced hyperlipidaemia. Fxr-null were fed 5% SA-supplemented diet for nine weeks and showed significant decreases levels liver triglycerides (p < 0.05), total cholesterol serum low-density lipoprotein-cholesterol 0.001). The expression fatty acid-synthesizing genes (Fas Scd1) cholesterol-metabolizing (Hmgcr, Hmgcs, Abca1), significantly reduced. Furthermore, supplementation altered gut microbiota increased abundance genus Oscillospira 0.001) Parabacteroides 0.01). These results suggest that lipid disruption influences composition mice.

Language: Английский

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Factors Affecting Gut Microbiota and Its Relationship with Cardiovascular Diseases: A Narrative Review

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 16, 2025

Context: The estimated population of microorganisms inhabiting the gastrointestinal tract is thought to exceed 1014, with a total weight approximately 2 kg. This accumulation microbiota indicates that number bacterial cells ten times greater than human cells, and gene content exceeds genome by more hundredfold. These are essential for maintaining health, having evolved over millions years. They influence vital processes in life, such as digestion regulation immune system. gut (GM) can be viewed dynamic environmental factor, its composition shaped host genetics, dietary patterns, hygiene practices, lifestyle choices. variability positions it potential therapeutic target cardiovascular disease (CVD) myocardial infarction (MI). Evidence Acquisition: present study review factors affecting intestinal relationship heart diseases. To ensure identification most relevant studies, common databases, including PubMed, Scopus, Web Science, were searched using terms "Gut dysbiosis", "Cardiovascular disease", "Probiotics", "prebiotics". articles abstracts obtained from search then reviewed. Results: Dysbiosis plays significant role onset progression atherosclerosis CVD. Microbiota-derived short-chain fatty acids (SCFAs) crucial development blood pressure. Alterations have been linked dysfunctions lipid metabolism, reduced levels high-density lipoprotein (HDL) plasma patients GM affect efficiency energy extraction sources, thereby impacting likelihood developing obesity through inflammation metabolism. Conclusions:

Language: Английский

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Alginate ameliorates hyperuricemia in mice by restoring hyperuricemia-induced renal and intestinal dysfunctions

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143422 - 143422

Published: April 1, 2025

Alginate, a bioactive polysaccharide fermentable by gut microbiota, has been shown to effectively reduce serum uric acid levels. However, its mechanisms and the role of microbiota remain unclear. In this study, we explored effects alginate with two different molecular weights on hyperuricemia mice. Both alginates exhibited potent hypouricemic through ABCG2 transporter upregulation, ameliorating hyperuricemia-induced renal intestinal dysfunctions, low-molecular-weight demonstrating enhanced bioavailability microbial biodegradation superior therapeutic efficacy in management. Additionally, found that alleviates dysbiosis induced enriching potentially beneficial bacteria. These include Limosilactobacillus Lactobacillus, which show significant negative correlation bacteria might regulate precursors during purine metabolism, thereby reducing accumulation. summary, study reveals protective damage mice highlights crucial microbiota. It provides valuable insights into mediate alginate.

Language: Английский

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Functional and Genomic Insights into the Biotechnological Potential of Vibrio spp. Isolated from Deeply Polluted and Pristine Environments

Current Microbiology, Journal Year: 2024, Volume and Issue: 82(1)

Published: Dec. 11, 2024

Language: Английский

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Bisphenol S impairs oocyte quality by inducing gut microbiota dysbiosis

mSystems, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

A good quality egg is essential for a successful pregnancy and early embryo development. Oocyte development vulnerable to environmental exposures. Bisphenol S (BPS) widely used as replacement its analog bisphenol A, but the reproductive toxicity of BPS has been great concern. In this study, we showed that exposure induces dysbiosis gut microbiota, which further leads intestinal permeability inflammation, ultimately impairs oocyte quality. More importantly, found alginate oligosaccharide reshapes microbiota improve homeostasis, thereby preventing deleterious effects on oocytes. Overall, study not only demonstrates intestine oocytes by inducing also develops preventive strategy.

Language: Английский

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