Contamination Status and Health Risk Assessment of 73 Mycotoxins in Four Edible and Medicinal Plants Using an Optimized QuEChERS Pretreatment Coupled with LC-MS/MS

Toxins, Journal Year: 2025, Volume and Issue: 17(2), P. 52 - 52

Published: Jan. 23, 2025

The current status of multi-mycotoxin contamination in edible and medicinal plants demands urgent development high-throughput analytical methods for mycotoxin detection. In this study, a reliable sensitive method the simultaneous analysis 73 mycotoxins was established successfully applied to detect 260 samples four dual-purpose (lotus seed, coix licorice root, dried tangerine peel). Sample preparation involved optimized QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) extraction combined with liquid–liquid purification, an enhanced ion pair library reduce matrix interference improve method’s universality. Method validation demonstrated recovery rates ranging from 61.6% 118.6% all compounds, relative standard deviations (RSDs) below 15%. limits detection (LODs) quantification (LOQs) ranged 0.25–12.25 μg/kg 0.5–25 μg/kg, respectively. Based on health risk assessment using Margin Exposure (MOE) Hazard Index (HI) methods, we found that is highly prevalent plants, different components being susceptible invasion by distinct fungal genera. Seed-type showed high susceptibility Aspergillus (53.3%) Fusarium (22.2%) contamination, MOE values 10,000 aflatoxins indicating potential risks. Physical state good storage conditions significantly influenced levels, fragmented showing substantially higher levels. Additionally, associated biosynthetic metabolic pathways were frequently detected simultaneously contaminated samples. these findings, recommend implementing strict moisture control during storage, maintaining intact product form where possible, establishing comprehensive supplier qualification systems. This study provides valuable reference monitoring similar plants.

Language: Английский

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Mycotoxins and consumers’ awareness: Recent progress and future challenges

Toxicon, Journal Year: 2023, Volume and Issue: 232, P. 107227 - 107227

Published: July 14, 2023

Language: Английский

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Recent Progress of Mycotoxin in Various Food Products—Human Exposure and Health Risk Assessment

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 865 - 865

Published: March 3, 2025

Mycotoxins, as prevalent contaminants in the food chain, exhibit diverse toxicological effects on both animals and humans. Chronic dietary exposure to mycotoxin-contaminated foods may result bioaccumulation of these toxins, posing substantial public health risks. This review systematically examines contamination patterns mycotoxins across major categories, including cereals related products, animal-derived foods, fruits, medical materials. Furthermore, we critically evaluated two methodological frameworks for assessing mycotoxin risks: (1) models integrating levels consumption data (2) human biomonitoring approaches quantifying biomarkers biological samples. A key contribution lies stratified analysis disparities among population subgroups (adults, teenagers, children, infants). Additionally, summarize current research relationship between associated impacts, with a particular emphasis vulnerable groups such pregnant women infants. By elucidating challenges inherent existing studies, this synthesis provides roadmap advancing risk characterization evidence-based safety interventions.

Language: Английский

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Nitrogen-doped carbon dot and DNA tetrahedron nanostructure based electrochemiluminescence aptasensor for AFB1 detection

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 401, P. 135024 - 135024

Published: Nov. 20, 2023

Language: Английский

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Studies of Mycotoxins in Medicinal Plants Conducted Worldwide over the Last Decade: A Systematic Review, Meta-Analysis, and Exposure Risk Assessment

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155367 - 155367

Published: Jan. 21, 2024

Language: Английский

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Signal-enhanced electrochemical sensor employing MWCNTs/CMK-3/AuNPs and Au@Pd core–shell structure for sensitive determination of AFB1 in complex matrix

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(10)

Published: Sept. 12, 2024

Language: Английский

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Cellular and molecular mechanisms of aflatoxin B1-mediated neurotoxicity: The therapeutic role of natural bioactive compounds

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116869 - 116869

Published: Aug. 9, 2023

Language: Английский

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Development of a sensitive simultaneous analytical method for 26 targeted mycotoxins in coix seed and Monte Carlo simulation-based exposure risk assessment for local population

Food Chemistry, Journal Year: 2023, Volume and Issue: 435, P. 137563 - 137563

Published: Oct. 5, 2023

Language: Английский

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Monte Carlo Simulation-Based Risk Assessment of Human Exposure to Multi-Mycotoxins In Platycladi Semen

Published: Jan. 1, 2025

Language: Английский

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Simultaneous determination of 202 pesticide residues and 19 mycotoxins in coix seed by QuEChERS coupled with LC-Q-TOF/MS and subsequent assessment of dietary exposure risk

Food Control, Journal Year: 2025, Volume and Issue: unknown, P. 111301 - 111301

Published: March 1, 2025

Language: Английский

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