Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19

Antioxidants, Journal Year: 2020, Volume and Issue: 9(6), P. 518 - 518

Published: June 12, 2020

Nrf2 is a transcription factor that regulates cellular redox balance and the expression of wide array genes involved in immunity inflammation, including antiviral actions. activity declines with age, making elderly more susceptible to oxidative stress-mediated diseases, which include type 2 diabetes, chronic viral infections. Published evidence suggests may regulate important mechanisms affecting susceptibility replication. We examined gene levels by GeneChip microarray RNA-seq assays. found potent Nrf2-activating composition PB125® downregulates ACE2 TMPRSS2 mRNA human liver-derived HepG2 cells. surface receptor activates spike protein for SARS-CoV-2 entry into host Furthermore, endotoxin-stimulated primary pulmonary artery endothelial cells, we report marked downregulation PB125 36 encoding cytokines. These IL-1-beta, IL-6, TNF-α, cell adhesion molecules ICAM-1, VCAM-1, E-selectin, group IFN-γ-induced genes. Many these cytokines have been specifically identified “cytokine storm” observed fatal cases COVID-19, suggesting activation significantly decrease intensity storm.

Language: Английский

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Transcription factor NRF2 as a promising therapeutic target for Alzheimer’s disease

Free Radical Biology and Medicine, Journal Year: 2020, Volume and Issue: 159, P. 87 - 102

Published: July 28, 2020

Language: Английский

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Extra Virgin Olive Oil Polyphenols: Modulation of Cellular Pathways Related to Oxidant Species and Inflammation in Aging

Cells, Journal Year: 2020, Volume and Issue: 9(2), P. 478 - 478

Published: Feb. 19, 2020

The olive-oil-centered Mediterranean diet has been associated with extended life expectancy and a reduction in the risk of age-related degenerative diseases. Extra virgin olive oil (EVOO) itself proposed to promote “successful aging”, being able virtually modulate all features aging process, because its great monounsaturated fatty acids content minor bioactive compounds, polyphenols above all. Polyphenols are mostly antioxidant anti-inflammatory abnormal cellular signaling induced by pro-inflammatory stimuli oxidative stress, as that related NF-E2-related factor 2 (Nrf-2) nuclear kappa-light-chain-enhancer activated B cells (NF-κB), which have identified important modulators disorders itself. This review summarizes existing literature about interaction between EVOO NF-κB Nrf-2 pathways. Reported studies show ability phenolics, mainly hydroxytyrosol tyrosol, activate signaling, inducing defense response prevent activation, thus suppressing induction phenotype. Literature data, although not exhaustive, indicate whole may significantly help so tightly connected stress chronic inflammation.

Language: Английский

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Natural Products in Alzheimer’s Disease Therapy: Would Old Therapeutic Approaches Fix the Broken Promise of Modern Medicines?

Molecules, Journal Year: 2019, Volume and Issue: 24(8), P. 1519 - 1519

Published: April 17, 2019

Despite extensive progress in understanding the pathology of Alzheimer’s disease (AD) over last 50 years, clinical trials based on amyloid–beta (Aβ) hypothesis have kept failing late stage human trials. As a result, just four old drugs limited outcomes and numerous side effects are currently used for AD therapy. This article assesses common pharmacological targets therapeutic principles current future drugs. It also underlines merits natural products acting through polytherapeutic approach monotherapy option Multi-targeting approaches general antioxidant anti-inflammatory mechanisms coupled with specific receptor and/or enzyme-mediated neuroprotection, neuroregeneration, other rational perspectives novel drug discovery emphasized.

Language: Английский

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The role of natural products in revealing NRF2 function

Natural Product Reports, Journal Year: 2020, Volume and Issue: 37(6), P. 797 - 826

Published: Jan. 1, 2020

NRF2 is a transcription factor that activated by many natural products for chemoprevention, but aberrant activation can lead to disease and have been used inhibit the pathway.

Language: Английский

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