Gender-Specific Behaviour in Obesity Stages I-II: Imbalance of Aminothiol Status and Adipomyokine Profile in Subjects with Different Insulin Resistance Severity

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

The hyperproduction of oxidative stress and inflammatory biomarkers, which is paralleled by decreased levels antioxidant anti‐inflammatory mediators, part cellular mechanisms that contribute to the disruption metabolic homeostasis in obesity. Whether gender‐specific alterations gender‐restricted associations these biomarkers underlie increased cardiometabolic risk men compared women unclear. We enrolled 31 29 men, aged ≥50 ≤70 years with body mass index ≥ 30 <40 kg/m 2 . assessed concentrations aminothiols (cysteine, homocysteine, glutathione), expression oxidant/antioxidant balance, adipomyokines (leptin, adiponectin, myostatin, interleukin‐6), markers chronic inflammation, vitamin D, an nutritional state, plasma serum samples using HPLC, ELISA, chemiluminescent immunoassay methods. measured insulin resistance (IR) model assessment (HOMA) index. Despite comparable visceral adiposity, IR, a similar dietary regimen, showed, respect women, higher oxidant lower levels, IR severity. Myostatin correlated prooxidant among only. Gender‐specific aminothiol status adipomyokine profile association between derangement are consistent age‐matched stage I‐II Strict control redox status, even addressing targets, may be useful prevent obesity‐related comorbidities.

Language: Английский

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Lipid peroxidation and sphingolipid alterations in the cerebral cortex and hypothalamus of rats fed a high-protein diet

Nutrition, Journal Year: 2022, Volume and Issue: 107, P. 111942 - 111942

Published: Dec. 13, 2022

High-protein diets (HPDs) are widely accepted to enhance satiety and energy expenditure thus have become a popular strategy lose weight facilitate muscle protein synthesis. However, long-term high-protein consumption could be linked with metabolic clinical problems such as renal liver dysfunctions. This study verified the effects of 8-wk ingestion on lipid peroxidation sphingolipid metabolism in plasma, cerebral cortex, hypothalamus rats.Immunoenzymatic spectrophotometric methods were applied assess oxidation-reduction (redox) biomarkers neutral sphingomyelinase activity, whereas gas-liquid chromatography high-performance liquid used examine levels.The vast majority HPD-related alterations was restricted hypothalamus. Specifically, an increased rate (increased hydroperoxides, 8-isoprostanes, thiobarbituric acid reactive substances) associated ceramide accumulation via activation de novo synthesis (decreased sphinganine), salvage pathway sphingosine), sphingomyelin hydrolysis activity) noted.This showed that HPD substantially affected hypothalamic pathways, which potentially alter output signals peripheral tissues.

Language: Английский

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Establishment of a novel weight reduction index after laparoscopic sleeve gastrectomy based on abdominal fat area

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Abstract Background: In light of ongoing research elucidating the intricacies obesity and metabolic syndrome, role abdominal fat (especially visceral fat) has been particularly prominent. Studies have revealed that adipose tissue can accelerate development syndrome by releasing various bioactive compounds hormones, such as lipocalin, leptin interleukin. Objectives The purpose this study was to ascertain reliability area other parameters valid predictors weight loss postoperatively. Method: A retrospective analysis performed on clinical data 167 patients with obesity. Among them, 105 who satisfied predefined inclusion exclusion criteria were included. evaluated included total area(TAFA), laboratory indicators anthropometric measurements. Weight reduction quantified through percent (%TWL) excess (%EWL) Binary logistic regression receiver operating characteristic (ROC) curve employed identify loss. Result: emphasized an independent predictor %EWL ≥ 75%(p < 0.001). Total area(p = 0.033) BMI(p 0.003) %TWL 30%. Conclusion: our cohort, at 1 year after surgery closely related preoperative third lumbar plane. Based these results, we formulated a novel P-index,exhibiting superior predictive value for excellent

Language: Английский

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Anti-inflammatory potentials of ethanolic leaf extract of Gongronema latifolium in streptozotocin induced diabetic rats

World Journal of Biology Pharmacy and Health Sciences, Journal Year: 2022, Volume and Issue: 11(1), P. 077 - 084

Published: July 30, 2022

Introduction: Inflammation due to diabetes mellitus has been understudied. Gongronema latifolium (GL) is reported have anti-inflammatory potentials. This work was designed evaluate the effect of ethanolic leaf extract on some inflammatory markers in Streptozotocin (STZ)-induced diabetic rats. Materials and methods: 40 Wistar rats both sexes (150 g-200 g) were divided into 5 groups eight (8) each. Group 1; control received normal saline placebo orally. 2; GL only 200 mg/kg 3 DM 65 bw STZ intraperitoneally for two days with an interval one day between. 4; + 200mg/kg GL. 5; Insulin 65mg/kgbw followed by 10 IU/kgbw insulin subcutaneously. For further study, paw oedema induced sub-plantar injection 2% formalin before after administration daily 7 days. Blood samples collected via cardiac puncture biochemical analysis. Results: Results from this study showed a significant (p<0.05) increase blood glucose group, compared control. Intervention significantly reduced level towards normal. Interleukin-6 concentration C-reactive proteins (p<0.01) higher group groups. Paw size increased treated Pretreatment post treatment size. Conclusion: In conclusion, (like insulin) hypoglycemic

Language: Английский

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