Effect of Tannic Acid on Antioxidant Function, Immunity, and Intestinal Barrier of Broilers Co-Infected with Coccidia and Clostridium perfringens DOI Creative Commons
Zhengfan Zhang, Pengtao Xu,

Chengao Liu

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(6), P. 955 - 955

Published: March 19, 2024

The purpose of this study was to determine the efficacy tannic acid on antioxidative function, immunity, and intestinal barrier broilers co-infected with coccidia Clostridium perfringens (CCP). A total 294 1-day-old arbor acres(AA) were divided into three groups: control group (CON), CCP (CCP), 1000 mg/kg TA + (CTA). This trial lasted for 28 days. results showed that decreased activity glutathione peroxidase (GSH-Px), superoxide dismutase (T-SOD), catalase (CAT), antioxidant capacity (T-AOC) levels increased contents hydrogen peroxide (H2O2) malondialdehyde (MDA) in jejunum (p < 0.05). mRNA GSH-Px3 CAT liver jejunum, GSH-Px3, SOD, HO-1, NAD(P)H quinone oxidoreductase I (NQO1) down-regulated by challenge In addition, Keap1 Nrf2 jejunal S-transferase (GST), heme-oxygenase-1 (HO-1) upregulated compared CON interleukin 8 (IL-8), IL-1β, inducible nitric oxide synthase (iNOS), interferon γ (IFN-γ) elevated, IL-10, zonula occludens protein1 (ZO-1), claudin-1, claudin-2, occludin treatment Dietary supplementation GSH-Px, T-SOD, CAT, T-AOC H2O2 MDA Compared group, level liver, alleviated rise IL-8, iNOS, IFN-γ decrease gene expression conclusion, addition diet improved barrier, mitigated inflammation, through activation transcription factor downstream Nrf2-Keap1 pathway NE condition.

Language: Английский

Lead induced genotoxicity and hepatotoxicity in zebrafish (Danio rerio) at environmentally relevant concentration: Nrf2-Keap1 regulated stress response and expression of biomarker genes DOI

Koushik Kumar Dey,

Sreejata Kamila,

Tanmoy Das

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 107, P. 104396 - 104396

Published: Feb. 22, 2024

Language: Английский

Citations

13
Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases DOI Creative Commons
Klaudia Leszto, Laura Biskup,

Klaudia Korona

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 688 - 688

Published: June 3, 2024

Cardiovascular diseases stand as the predominant global cause of mortality, exerting a profound impact on both life expectancy and its quality. Given their immense public health burden, extensive efforts have been dedicated to comprehending underlying mechanisms developing strategies for prevention treatment. Selenium, crucial participant in redox reactions, emerges notable factor maintaining myocardial cell homeostasis influencing progression cardiovascular disorders. Some disorders, such Keshan disease, are directly linked with environmental deficiency. Nevertheless, precise extent system remains unclear, marked by contradictory findings existing literature. High selenium levels associated an increased risk hypertension, while lower concentrations heart failure atrial fibrillation. Although some trials shown potential effectiveness specific groups patients, large cohort supplementation attempts generally yielded unsatisfactory outcomes. Consequently, there persists significant need further research aimed at delineating patient cohorts that would benefit from supplementation.

Language: Английский

Citations

12
Mechanisms of chondrocyte regulated cell death in osteoarthritis: Focus on ROS-triggered ferroptosis, parthanatos, and oxeiptosis DOI

Fangyang Fan,

Cheng Yang,

Enran Piao

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 705, P. 149733 - 149733

Published: Feb. 28, 2024

Language: Английский

Citations

10
The multifaceted role of mitochondria in autism spectrum disorder DOI Creative Commons
Igor Khaliulin,

Wajeha Hamoudi,

Haitham Amal

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Normal brain functioning relies on high aerobic energy production provided by mitochondria. Failure to supply a sufficient amount of energy, seen in different disorders, including autism spectrum disorder (ASD), may have significant negative impact development and support functions. Mitochondrial dysfunction, manifested the abnormal activities electron transport chain impaired metabolism, greatly contributes ASD. The aberrant this organelle is such importance that ASD has been proposed as mitochondrial disease. It should be noted not only function In particular, these organelles are involved regulation Ca 2+ homeostasis, mechanisms programmed cell death, autophagy, reactive oxygen nitrogen species (ROS RNS) production. Several syndromes originated from mitochondria-related mutations display phenotype. Abnormalities handling ATP mitochondria affect synaptic transmission, plasticity, development, contributing ROS regulate activity permeability transition pore (mPTP). prolonged opening affects redox state mitochondria, impairs oxidative phosphorylation, activates apoptosis, ultimately leading death. A dysregulation between enhanced processes apoptosis inhibited autophagy leads accumulation toxic products brains individuals with Although many still investigated, whether they cause or consequence unknown, accumulating data show breakdown any functions contribute review, we discuss multifaceted role various aspects neuroscience.

Language: Английский

Citations

10
Physical activity can reduce the risk of blood cadmium and blood lead on stroke: Evidence from NHANES DOI

Xiaoqi Deng,

Dichuan Liu,

Miao Li

et al.

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 483, P. 116831 - 116831

Published: Jan. 22, 2024

Language: Английский

Citations

9
Selenium nanoparticles ameliorate lumbar disc degeneration by restoring GPX1-mediated redox homeostasis and mitochondrial function of nucleus pulposus cells DOI Creative Commons
Wei He, Xin Tian, Quan Zhou

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 18, 2024

Intervertebral disc degeneration (IVDD) is a prevalent musculoskeletal disorder that involves the excessive accumulation of reactive oxygen species (ROS), resulting in mitochondrial dysfunction and matrix metabolism imbalance nucleus pulposus cells (NPCs). Selenium, an indispensable trace element, plays crucial role maintaining redox homeostasis by being incorporated into antioxidant selenoproteins as selenocysteine. In this study, we employed straightforward synthesis method to produce selenium nanoparticles (SeNPs) with consistent size distribution, evaluated their potential protective effects ameliorating IVDD. simulated inflammatory environment induced interleukin-1beta (IL-1β) vitro, SeNPs demonstrated effect on capacity NPCs through up-regulation aggrecan type II collagen, while concurrently suppressing expression degradation enzymes including MMP13 ADAMTS5. Additionally, preserved integrity restored impaired energy activating glutathione peroxidase1 (GPX1) rebalance homeostasis. rat lumbar model puncture, local administration hydration tissue, promoted deposition, effectively mitigated progression Our results indicate enhancement GPX1 may offer promising therapeutic approach for IVDD restoring function

Language: Английский

Citations

9
Reductive stress: The key pathway in metabolic disorders induced by overnutrition DOI Creative Commons
Shiyi Zhang, Na Wang,

Zhichao Gao

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The balance of redox states is crucial for maintaining physiological homeostasis. For decades, the focus has been mainly on concept oxidative stress, which involved in mechanism almost all diseases. However, robust evidence highlighted that reductive other side spectrum, plays a pivotal role development various diseases, particularly those related to metabolism and cardiovascular health. In this review, we present an extensive array occurrence stress its significant implications metabolic Reductive defined as shift cellular towards more reduced state, characterized by excess endogenous reductants (such NADH, NADPH, GSH) over their oxidized counterparts (NAD+, NADP+, GSSG). While predominant studied obesity, disorders, growing underscores critical stress. This review discusses how contributes pathologies, emphasizing effects key processes. example, excessive NADH accumulation can disrupt mitochondrial function impairing electron transport chain, leading decreased ATP production increased reactive oxygen species. endoplasmic reticulum (ER), equivalents hampers protein folding, triggering ER activating unfolded response, lead insulin resistance compromised Furthermore, explore antioxidant supplementation exacerbate further shifting balance, potentially undermining beneficial exercise, health, aggravating obese individuals. body calls reevaluation disease pathogenesis therapeutic interventions.

Language: Английский

Citations

1
Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease DOI Creative Commons

Zhihao Qi,

Quan Li, Shuhua Yang

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 231 - 231

Published: Jan. 19, 2025

DNA damage repair (DDR) plays a key role in maintaining genomic stability and developing inflammatory bowel disease (IBD). However, no report about the causal association between DDR IBD exists. Whether DDR-related genes are precise to etiology remains unclear. Herein, we employed multi-omics summary data-based Mendelian randomization (SMR) approach ascertain potential effects of IBD. Methods: Summary statistics from expression quantitative trait loci (eQTL), methylation QTL (mQTL), protein (pQTL) on European descent were included. The GWAS summarized data for its two subtypes, Crohn’s (CD) ulcerative colitis (UC), acquired FinnGen study. We elected genetic variants located within or near 2000 cis, which closely associated with gene changes. Variants selected as instrumental variables (IVs) assessed causality subtypes using both SMR two-sample MR (TSMR) approaches. Colocalization analysis was evaluate whether single variant simultaneously influences traits, thereby validating pleiotropy hypothesis. Results: identified seven (Arid5b, Cox5a, Erbb2, Ube2l3, Gpx1, H2bcl2, Mapk3), 33 genes, proteins (CD274 FCGR2A) all causally subtypes. Beyond causality, integrated mQTL-eQTL conducted druggability values. found that Erbb2 Gpx1 significantly impacted their levels offering insights into regulatory mechanisms risk Meanwhile, CD247 FCGR2A could serve targets pharmacological interventions Conclusions: Our study demonstrates based data-driven MR. Moreover, targets.

Language: Английский

Citations

1
Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-κB pathway DOI Creative Commons

Lifu Lei,

Fuwei Zhang, Juan Huang

et al.

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 200, P. 59 - 72

Published: March 2, 2023

Language: Английский

Citations

22
Antioxidant Properties of Selenium Nanoparticles Synthesized Using Tea and Herb Water Extracts DOI Creative Commons
Aleksandra Sentkowska, Krystyna Pyrzyńska

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(2), P. 1071 - 1071

Published: Jan. 13, 2023

Selenium nanoparticles (SeNPs) are the object of great interest due to their potential be used in many areas industry and medicine. Work is still underway on synthesis methods; however, green methodologies becoming more popular. In this study, aqueous extracts black tea as well infusions popular herbs such chamomile mint were SeNPs serving Se(IV) reducers its nano form. The influence reagents concentration ratios properties obtained examined. showed a greater ability neutralize hydroxyl radicals compared extracts. It has been proven that infusion selenium-containing tea, formation occurs.

Language: Английский

Citations

21