Basic Research in Cardiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
Abstract
Breast
cancer,
the
most
prevalent
cancer
affecting
women
worldwide,
poses
a
significant
cardio-oncological
burden.
Despite
advancements
in
novel
therapeutic
strategies,
anthracyclines,
HER2
antagonists,
and
radiation
remain
cornerstones
of
oncological
treatment.
However,
each
carries
risk
cardiotoxicity,
though
molecular
mechanisms
underlying
these
adverse
effects
differ.
Common
include
DNA
damage
response,
increased
reactive
oxygen
species,
mitochondrial
dysfunction,
which
are
key
areas
ongoing
research
for
potential
cardioprotective
strategies.
Since
also
essential
effective
tumor
cytotoxicity,
we
explore
tumor-specific
effects,
particularly
hereditary
breast
linked
to
BRCA1
BRCA2
mutations.
These
genetic
variants
impair
repair
mechanisms,
increase
tumorigenesis
possibly
cardiotoxicity
from
treatments
such
as
anthracyclines
antagonists.
Novel
therapies,
including
immune
checkpoint
inhibitors,
used
clinic
triple-negative
improve
outcomes
patients.
This
review
discusses
BRCA
dysfunction
associated
pathological
pathways.
It
gives
an
overview
preclinical
models
genetically
engineered
mouse
models,
syngeneic
murine
humanized
various
vitro
ex
vivo
systems
study
cardiovascular
side
therapies.
Understanding
mechanism
developing
strategies
improving
treatment
reducing
long-term
risks
Oncology and Therapy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 8, 2025
CT-P6,
the
first
trastuzumab
biosimilar,
was
approved
on
basis
of
data
limited
to
human
epidermal
growth
factor
receptor-2
(HER2)-positive
early
breast
cancer.
Usage
for
other
indications
granted
by
extrapolation,
and
post-approval
clinical
studies
were
conducted
confirm
effect
CT-P6
in
HER2-positive
gastric
After
approval
Japan
2018,
a
prospective
post-marketing
surveillance
171
patients
(130
male,
41
female)
with
unresectable
advanced
or
recurrent
The
safety
efficacy
evaluated
over
1
year.
primarily
combined
fluoropyrimidine
and/or
platinum
agents.
Adverse
events
occurred
151
(88.3%),
55
(32.2%)
experiencing
grade
3
higher.
Infusion
reactions
12.3%.
Four
cardiac
disorders
reported:
two
dysfunction
severe
ischemic
heart
disease.
Interstitial
lung
disease
reported
four
(2.3%).
objective
response
rate
34.4%,
control
82.4%.
progression-free
survival
(PFS)
7.4
months.
Significant
risk
factors
PFS
included
gastroesophageal
junction,
≥
metastases,
no
gastrectomy,
prior
chemotherapy,
agent.
In
this
cohort
study,
demonstrated
sufficient
new
concerns
cancer,
serving
as
cost-effective
alternative
originator
trastuzumab.
Registry
Clinical
Trials,
Trial
ID:
jRCT2071230094
(November
2023).
International Journal of Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
54(6)
Published: Oct. 1, 2024
The
early
restoration
of
hemodynamics/reperfusion
in
acute
myocardial
infarction
(AMI)
is
an
effective
therapeutic
strategy
to
reduce
sudden
death
and
improve
patient
prognosis.
However,
reperfusion
induces
additional
cardiomyocyte
damage
cardiac
tissue
dysfunction.
In
this
context,
turmeric‑derived
curcumin
(Cur)
has
been
shown
exhibit
a
protective
effect
against
ischemia/reperfusion
injury
(I/RI).
molecular
mechanism
its
activity,
however,
remains
unclear.
current
study
investigated
the
Cur
via
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12463 - 12463
Published: Nov. 20, 2024
Skeletal
muscle
atrophy
is
a
major
health
concern,
severely
affecting
the
patient's
mobility
and
life
quality.
In
pathological
process
of
skeletal
atrophy,
with
progressive
decline
in
quality,
strength,
function,
incidence
falling,
fracture,
death
greatly
increased.
Unfortunately,
there
are
no
effective
treatments
for
this
devastating
disease.
Thus,
it
imperative
to
investigate
exact
molecular
mechanisms
underlying
development
identify
new
therapeutic
targets.
Decreased
mass,
fiber
cross-sectional
area
typical
features
manifestations
atrophy.
Ferroptosis,
an
emerging
type
programmed
cell
death,
characterized
by
iron-dependent
oxidative
damage,
lipid
peroxidation,
reactive
oxygen
species
accumulation.
Notably,
understanding
its
role
emerging.
Ferroptosis
has
been
found
play
important
intricate
interplay
between
progression
caused
multiple
factors.
This
provides
opportunities
challenges
treatment
Therefore,
we
systematically
elucidated
ferroptosis
mechanism
progress
aiming
provide
comprehensive
insight
into
relationship
from
perspectives
iron
metabolism
peroxidation
insights
targeting
pathways
related
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Dec. 22, 2024
The
identification
of
ferroptosis
represents
a
pivotal
advancement
in
the
field
cell
death
research,
revealing
an
entirely
novel
mechanism
cellular
demise
and
offering
new
insights
into
initiation,
progression,
therapeutic
management
various
diseases.
Ferroptosis
is
predominantly
induced
by
intracellular
iron
accumulation,
lipid
peroxidation,
or
impairments
antioxidant
defense
system,
culminating
membrane
rupture
consequent
death.
Studies
have
associated
with
wide
range
diseases,
enhancing
our
comprehension
its
underlying
mechanisms,
we
can
formulate
innovative
strategies,
thereby
providing
renewed
hope
for
patients.
Journal of Cardiovascular Pharmacology,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 10, 2023
Ferroptosis
is
a
form
of
iron-regulated
cell
death
implicated
in
wide
array
diseases,
including
heart
failure,
hypertension,
and
numerous
cardiomyopathies.
In
addition,
mitochondrial
dysfunction
has
been
associated
with
several
these
same
disease
states.
However,
the
role
mitochondrion
ferroptotic
remains
debated.
As
major
regulator
cellular
iron
levels,
mitochondria
may
very
well
play
crucial
mechanisms
behind
ferroptosis,
but
at
this
point,
not
adequately
defined.
Emerging
evidence
from
our
laboratory
others
indicates
critical
Sirtuin
3,
deacetylase
linked
longevity
protection
against
conditions,
prevention
cardiovascular
diseases.
Here,
we
provide
brief
overview
potential
roles
3
homeostasis
its
contribution
to
cardiomyopathy
Friedreich's
ataxia
diabetic
cardiomyopathy.
We
also
discuss
current
knowledge
involvement
ferroptosis
other
states,
doxorubicin-induced
cardiomyopathy,
insight
into
areas
requiring
further
investigation.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(2)
Published: March 1, 2024
Abstract
Autophagy
is
a
process
in
which
cells
degrade
intracellular
substances
and
play
variety
of
roles
cells,
such
as
maintaining
homeostasis,
preventing
cell
overgrowth,
removing
pathogens.
It
highly
conserved
during
the
evolution
eukaryotic
cells.
So
far,
study
autophagy
still
hot
topic
field
cytology.
Ferroptosis
an
iron‐dependent
form
death,
accompanied
by
accumulation
reactive
oxygen
species
lipid
peroxides.
With
deepening
research,
it
has
been
found
that
ferroptosis,
like
autophagy,
involved
occurrence
development
cardiovascular
diseases.
The
relationship
between
ferroptosis
complex,
association
two
disease
remains
to
be
clarified.
This
article
reviews
mechanism
their
correlation,
discusses
them
diseases,
expected
provide
new
important
treatment
strategies
for
