Pectin/Caffeic Acid Nanoparticles in a Poloxamer Thermosensitive Gel for the Treatment of Ulcerative Colitis by inhibiting cGAS-STING pathway DOI
Shilin Zhou, Zugong Yu,

Wenqing Yao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 247, P. 114419 - 114419

Published: Nov. 30, 2024

Language: Английский

Regulation on Mitophagy in Adenomyosis by Guizhi Fuling Wan DOI

Shidan Liu,

Chenjie Li, Xianyun Fu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119570 - 119570

Published: Feb. 1, 2025

Language: Английский

Citations

1
Immp2l gene knockout induces granulosa cell senescence by activation of cGAS-STING pathway via TFAM-mediated mtDNA leakage DOI

Pengge Pan,

Saihong Cao,

Hui Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142368 - 142368

Published: March 1, 2025

Language: Английский

Citations

1
The cGAS-STING pathway and female reproductive system diseases DOI Creative Commons

Ruijie Li,

Hengwei Liu,

Yi Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 9, 2024

The cGAS-STING pathway has become a crucial role in the detection of cytosolic DNA and initiation immune responses. not only mediates protective defense against various DNA-containing pathogens but also detects tumor-derived to generate intrinsic anti-tumor immunity. However, abnormal activation by self-DNA can lead autoimmune diseases inflammatory disorders. This article reviews mechanisms functions pathway, as well latest research progress female reproductive-related diseases. We focus on regulatory roles this common reproductive disorders, discuss clinical potential biomarkers therapeutic agents for diseases, controversies, technical issues, biological knowledge gaps that need be resolved. Furthermore, we provide new ideas treatment prevention these

Language: Английский

Citations

1
Research Advances in Adenomyosis-Related Signaling Pathways and Promising Targets DOI Creative Commons
Hongyu Zhang, Chaoming Li, Wenyan Li

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1402 - 1402

Published: Nov. 4, 2024

Adenomyosis is a benign gynecological condition characterized by the proliferation of endometrial stroma and glands into myometrium, uterine volume enlargement, peripheral smooth muscle hypertrophy. The typical clinical symptoms include chronic pelvic pain, abnormal bleeding, subfertility, all which significantly impact quality life. There are no effective prevention or treatment strategies for adenomyosis, partly due to limited understanding pathological mechanisms underlying initiation progression disease. Given that signaling pathways play crucial role in development better these essential identifying therapeutic targets advancing drug development. occurrence adenomyosis closely linked various pathophysiological mechanisms, including proliferation, migration, invasion, fibrosis, angiogenesis, inflammation, oxidative stress, immune response, epigenetic changes. This review summarizes associated with pathogenesis CXCL/CXCR, NLRP3, NF-κB, TGF-β/smad, VEGF, Hippo/YAP, PI3K/Akt/mTOR, JAK/STAT, other relevant pathways. In addition, it identifies promising future treatment, such as m6A, GSK3β, sphks, etc.

Language: Английский

Citations

1
Pectin/Caffeic Acid Nanoparticles in a Poloxamer Thermosensitive Gel for the Treatment of Ulcerative Colitis by inhibiting cGAS-STING pathway DOI
Shilin Zhou, Zugong Yu,

Wenqing Yao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 247, P. 114419 - 114419

Published: Nov. 30, 2024

Language: Английский

Citations

0