Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 30, 2025
Gynecological cancers, including cervical, ovarian, and endometrial malignancies, remain a significant global health burden, exacerbated by disparities in access to preventive measures such as HPV vaccination routine screening. The cGAS/STING signaling pathway, pivotal mechanism innate immunity, detects cytosolic DNA from pathogens or cellular damage, triggering immune responses via type I interferons inflammatory cytokines. This pathway’s dual role gynecological either promoting antitumor immunity facilitating tumor evasion, makes it compelling target for innovative therapies. article outlines cGAS/STING’s influence on microenvironments, surveillance, inflammation, with emphasis molecular mechanisms driving cancer progression. It explores interactions between damage response pathways modulation, highlighting the impact of activation suppression cancers. therapeutic potential STING agonists, PARP inhibitors, targeted immunotherapies is reviewed, demonstrating how these approaches can boost responses, counteract chemotherapy resistance, improve patient outcomes. study also discusses strategies leveraging enhance efficacy address tumor-mediated suppression, providing insights into future directions personalized treatments.
Language: Английский