Review of cadmium toxicity effects on fish: Oxidative stress and immune responses

Environmental Research, Journal Year: 2023, Volume and Issue: 236, P. 116600 - 116600

Published: July 8, 2023

Language: Английский

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Molecular mechanism of selenium against lead-induced apoptosis in chicken brainstem relating to heat shock protein, selenoproteins, and inflammatory cytokines

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116028 - 116028

Published: Feb. 3, 2024

Extensive application of lead (Pb) brought about environmental pollution and toxic reactions organisms. Selenium (Se) has the effect antagonizing Pb poisoning in humans animals. However, it is still unclear how causes brainstem toxicity. In present study, we wanted to investigate whether Se can alleviate toxicity chicken brainstems by reducing apoptosis. One hundred eighty chickens were randomly divided into four groups, namely control group, Se/Pb group. Morphological examination, ultrastructural observation, relative mRNA expressions genes on heat shock proteins (HSPs); selenoproteins; inflammatory cytokines; apoptosis-related factors investigated. The results showed that exposure led tissue damage apoptosis brainstems. Furthermore, an atypical expression HSPs (HSP27, HSP40, HSP60, HSP70, HSP90); selenoprotein family glutathione peroxidase (GPx) 1, GPx2, GPx3, GPx4), thioredoxin reductases (Txnrd) (Txnrd1, Txnrd2, Txnrd3), dio famliy (diodothyronine deiodinases (Dio)1, Dio2, Dio3), as well other selenoproteins (selenoprotein (Sel)T, SelK, SelS, SelH, SelM, SelU, SelI, SelO, Selpb, n1 (Sepn1), Sepp1, Sepx1, Sepw1, 15-kDa (Sep15), selenophosphate synthetases 2 (SPS2)); cytokines (Interleukin (IL-2), IL-4, IL-6, IL-12β, IL-17, Interferon-γ (IFN-γ)); (B-cell lymphoma-2 (Bcl-2), tumor protein 53 (p53), Bcl-2 Associated X (Bax), Cytochrome c (Cyt c), Caspase-3) identified. An reaction induced after Pb. alleviated abnormal HSPs, selenoproteins, cytokines, tissues treated with indicated inflammatory, involved Se-resisted poisoning. Overall, had resistance against poisoning, be act antidote for

Language: Английский

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Molecular mechanism of kidney damage caused by abamectin in carp: Oxidative stress, inflammation, mitochondrial damage, and apoptosis

Toxicology, Journal Year: 2023, Volume and Issue: 494, P. 153599 - 153599

Published: July 25, 2023

Language: Английский

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Molecular Mechanisms of Selenium Mitigating Lead Toxicity in Chickens via Mitochondrial Pathway: Selenoproteins, Oxidative Stress, HSPs, and Apoptosis

Toxics, Journal Year: 2023, Volume and Issue: 11(9), P. 734 - 734

Published: Aug. 25, 2023

Lead (Pb), a hazardous heavy metal, can damage the health of organisms. However, it is not clear whether Pb chicken cerebellums and thalami. Selenium (Se), an essential nutrient for organisms, has palliative effect on poisoning in chickens. In our experiment, model chickens treated with Se alone combination was established to investigate molecular mechanism alleviating Pb-caused both Our morphological results indicated that caused apoptotic lesions, such as mitochondrial nuclear damage. Further, anti-apoptotic gene Bcl-2 decreased; contrary, four pro-apoptotic genes (p53, Bax, Cyt c, Caspase-3) increased under treatment, meaning apoptosis via p53-Cyt c-Caspase-3 pathway. Furthermore, we further demonstrated elevated HSPs (HSP27, HSP40, HSP70, HSP90), well HSP70 took part apoptosis. addition, found exposure led oxidative stress up-regulating oxidant H2O2 down-regulating antioxidants (CAT, SOD, GST, GPx). Moreover, decreased three Se-containing factors (Txnrd1, Txnrd2, Txnrd3), confirming stress. Interestingly, supplementation reversed above changes by alleviated Pb-induced A time dependency Bcl-2, c cerebellums, CAT, GPx, p53 thalami Pb-exposed HSP27 were more sensitive than those respectively, exposure. severe cerebellums. conclusion, after Txnrds mediated stress, up-regulated HSPs, finally, triggered antagonized pathway selenoproteins This study provides new information environmental pollutant detoxification abiotic

Language: Английский

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Cypermethrin induces apoptosis, autophagy and inflammation via ERS-ROS-NF-κB axis in hepatocytes of carp (Cyprinus carpio)

Pesticide Biochemistry and Physiology, Journal Year: 2023, Volume and Issue: 196, P. 105625 - 105625

Published: Sept. 22, 2023

Language: Английский

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Heat stress induced hepatocyte apoptosis in largemouth bass Micropterus salmoides via IRE1α/TRAF2/ASK1/JNK pathway

Journal of Oceanology and Limnology, Journal Year: 2024, Volume and Issue: 42(3), P. 988 - 1000

Published: Feb. 2, 2024

Language: Английский

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Ameliorative Effect of Thymoquinone and Thymoquinone Nanoparticles against Diazinon-Induced Hepatic Injury in Rats: A Possible Protection Mechanism

Toxics, Journal Year: 2023, Volume and Issue: 11(9), P. 783 - 783

Published: Sept. 15, 2023

The health benefits of thymoquinone (TQ) have been a significant focus numerous studies. However, more research is needed to ascertain whether its nano-form can effectively treat or prevent chronic diseases. In this study, we investigated how and nanoparticles mitigate liver damage induced by diazinon in male Wistar rats explored the intracellular mechanisms involved. Forty-two (n = 42) were randomly allotted into seven groups. Group 1 served as control. 2 (vehicle) consisted that received corn oil via gastric tube daily. 3 (TQ), given daily oral administration TQ (40 mg/kg bw). 4 (thymoquinone nanoparticles, NTQ) included NTQ (0.5 bw) orally for 21 days. 5 (DZN) involved administered (DZN, 15 orally. 6 (TQ + DZN), first orally, followed DZN. 7 (NTQ DZN) receiving then After days treatment, euthanized. DZN, enzymes significantly elevated (p < 0.05). Additionally, there noticeable increases oxidative injury markers, such nitric oxide, malondialdehyde, redox oxygen radicals, overall hydrogen peroxide protein carbonyl concentrations. This was accompanied upregulation apoptotic markers (Bax, caspase9, caspase 3, bax/Bcl2 ratio), inflammatory cytokines (TNF-α, IL-6), DNA damage. There also noteworthy decrease 0.05) activities antioxidant anti-apoptotic markers. nanoparticle form mitigated these complications; our histopathological findings corroborated biochemical molecular observations. conclusion, properties thymoquinone, form, tandem with downregulation cytokines, provided protective effect against hepatic dysfunction caused diazinon.

Language: Английский

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Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 141, P. 109000 - 109000

Published: Aug. 18, 2023

Language: Английский

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From antioxidant defense system damage to programmed cell apoptosis: Understanding lethal mechanisms of cypermethrin on fish kidneys

Process Safety and Environmental Protection, Journal Year: 2024, Volume and Issue: 183, P. 848 - 858

Published: Jan. 22, 2024

Language: Английский

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Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126953 - 126953

Published: Sept. 19, 2023

Language: Английский

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