Food Quality and Safety,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 21, 2024
Abstract
Hericium
erinaceus–derived
peptides
have
been
found
to
exhibit
various
bioactivities,
including
immunoregulatory
properties.
This
study
investigated
the
transport,
absorption,
and
potential
immunomodulatory
activities
of
a
new
peptide,
LPGKVIAS,
derived
from
H.
erinaceus.
Transport
absorption
LPGKVIAS
were
analyzed
by
near-infrared
fluorescence
in
vivo
imaging
mice
injected
with
probe–labeled
LPGKVIAS.
RNA
sequencing
was
used
explore
immunological
effects
peptide
on
mouse
splenocytes.
Kyoto
Encyclopedia
Genes
Genomes
pathway
analysis
showed
that
LPGKVAS
upregulated
differentially
expressed
genes
involved
immune
regulation.
Notably,
activation
lysosome–phagosome
splenocytes
treated
identified
as
crucial
defense
mechanism
against
pathogen
infection.
Furthermore,
reverse
transcription–polymerase
chain
reaction
studies
validated
gene
expression
data,
supporting
application
an
immunomodulator.
BMC Genomics,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: Jan. 15, 2025
Tris
(2-chloroethyl)
phosphate
(TCEP),
a
widely
used
flame
retardant,
is
widespread
in
the
environment
and
potentially
harmful
to
organisms.
However,
specific
mechanisms
of
TCEP-induced
neurological
reproductive
toxicity
fish
are
largely
unknown.
Turbot
(Scophthalmus
maximus)
cultivated
on
large
scale,
emergence
pollutants
with
endocrine
disrupting
effects
seriously
affects
its
economic
benefits.
This
study
aimed
investigate
toxic
TCEP
turbot
by
integrating
physio-biochemical
transcriptomic
analyses.
exposure
induced
severe
neuroendocrine
turbot.
Firstly,
hormone
levels
luteinizing
(LH),
follicle-stimulating
(FSH),
estradiol
(E2),
11-ketotestosterone
(11-KT)
were
significantly
decreased
under
prolonged
stress,
which
may
have
negative
impact
normal
function.
We
identified
summarized
representative
differentially
expressed
genes
(DEGs)
their
functions,
such
as
system
oxidative
stress.
Pathway
enrichment
showed
that
toxicological
characteristics
regulation
disorders,
including
phosphorylation,
apoptosis,
steroid
biosynthesis,
GnRH
signaling
pathway
so
on.
Weighted
gene
co-expression
network
analysis
(WGCNA)
also
revealed
key
involved
these
pathways.
Among
genes,
those
encoding
components
electron
transport
chain
presented
an
initial
increase
expression
followed
decrease,
indicating
stress
might
affect
mitochondrial
function
lead
cell
damage.
finding
was
supported
upregulation
apoptosis-related
expression.
Moreover,
acute
regulated
MAPK-mediated
transduction
signaling,
thereby
altering
hypothalamic-pituitary-gonadal
(HPG)
axis-related
genes.
These
findings
biomarkers
related
toxicity,
providing
early
warning
for
monitoring
healthy
aquaculture.
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(2), P. 120 - 120
Published: Feb. 11, 2025
Objectives:
Sodium
butyrate
(SB)
is
a
typical
postbiotic
known
to
positively
affect
economic
animals
in
recent
years,
but
research
on
SB
pet
cats
scarce.
Consequently,
this
study
sought
explore
the
influence
of
anti-inflammatory
and
antioxidant
capacity,
immune
function,
gut
microbiota
adult
through
assessment
biochemical
parameters
comprehensive
integrative
omics
analysis.
Methods:
A
total
30
were
divided
into
three
groups:
basal
diet
(NC),
with
0.05%
(SB5),
0.1%
(SB10).
The
experiment
lasted
for
6
weeks.
Results:
results
indicated
that
fecal
level
calprotectin
was
lower
SB10
group
than
SB5
NC
groups.
reduced
serum
levels
TNF-α,
IL-1β
DAO
compared
(p
<
0.05).
In
addition,
increased
GSH-Px
decreased
MDA
content
Transcriptomic
analysis
showed
gene
expression
VCAM1
exhibited
notable
decrease
revealed
richness
higher
0.05),
abundance
Lachnospiraceae,
Lachnoclostridium,
Blautia,
Roseburia
greater
Conclusions:
Dietary
could
enhance
improve
regulate
composition
cats.
