Atrazine exposure promotes cardiomyocyte pyroptosis to exacerbate cardiotoxicity by activating NF-κB pathway

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 915, P. 170028 - 170028

Published: Jan. 14, 2024

Language: Английский

---

Selenomethionine modulates the JAK2 / STAT3 / A20 pathway through oxidative stress to alleviate LPS-induced pyroptosis and inflammation in chicken hearts

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2024, Volume and Issue: 1868(4), P. 130564 - 130564

Published: Jan. 23, 2024

Language: Английский

---

Soil health hazards of di(2-ethylhexyl) phthalate: New perspectives on earthworms from different ecological niches DNA damage, gut microbial disruption and soil enzyme changes

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 467, P. 133700 - 133700

Published: Feb. 3, 2024

Language: Английский

---

Serum protein α-klotho mediates the association between lead, mercury, and kidney function in middle-aged and elderly populations

Environmental Health and Preventive Medicine, Journal Year: 2025, Volume and Issue: 30(0), P. 10 - 10

Published: Jan. 1, 2025

Heavy metals are significant risk factors for kidney function. Numerous studies have shown that exposure to heavy negatively correlates with function through oxidative stress pathways, and serum α-klotho is linked stress. However, the role of in relationship between blood lead, mercury, remains unclear. This study evaluated mediating alpha-klotho mercury renal function, using data from 2007-2016 National Health Nutrition Examination Survey (NHANES) U.S. adults aged 40-79. The sample included 11,032 participants, α-klotho, other relevant covariates measured. Inductively coupled plasma mass spectrometry was used assess lead levels, enzyme-linked immunosorbent assay (ELISA) employed measure α-klotho. Kidney estimated glomerular filtration rate (eGFR) based on creatinine levels. Multivariable linear regression conducted analyze relationships eGFR. A mediation analysis model whether influenced these associations. We observed a association Mediation revealed accounted 12.76% eGFR NHANES population. Subgroup showed mediated 12.43%, 6.87%, 21.50% 5.44% women, middle-aged (40-59 years old), without cardiovascular disease hypertension, respectively. did not mediate terms gender or age. newly identified pathway may provide valuable insights prevention treatment mechanisms related impairment. found associated According results subgroup analysis, females, middle 60-79 years. clinically significant, α-Klotho clinical significance.

Language: Английский

---

Evaluation of the effect of cannabidiol on the THLE-2 liver cell line exposed to lead

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 923, P. 170901 - 170901

Published: Feb. 22, 2024

Language: Английский

---

Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus

Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: 148, P. 13 - 26

Published: Jan. 21, 2024

Language: Английский

---

Golgi apparatus regulated pyroptosis through the miR-32-5p/Golga7/NLRP3 axis in chicken splenic lymphocytes exposure to ammonia

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 124923 - 124923

Published: Sept. 1, 2024

Language: Английский

---

Resveratrol alleviates Mono-2-ethylhexyl phthalate-induced mitophagy, ferroptosis, and immunological dysfunction in grass carp hepatocytes by regulating the Nrf2 pathway

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 371, P. 123235 - 123235

Published: Nov. 6, 2024

Language: Английский

---

Artichoke water extract protects against Lead-induced hepatotoxicity by activating Nrf2 signaling and inhibiting NLRP3/caspase-1/GSDMD-mediated pyroptosis

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119654 - 119654

Published: March 1, 2025

Language: Английский

---

Influence and molecular mechanism of cinnamaldehyde against ventricular arrhythmia via the TAK1-p38MAPK-NLRP3 pathway

Heart and Vessels, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Based on the transforming growth factor β-activated kinase 1 (TAK1)-p38 mitogen-activated protein (p38MAPK)-nucleotide-binding oligo-like receptor 3 (NLRP3) signalling pathway, protective effect and mechanism of isoproterennaline (ISO)-induced cinnamaldehyde inflammatory injury in ventricular rats were investigated. Fifty male SPF SD randomly assigned to normal group, model propranolol low-dose group or high-dose group. The arrhythmia was constructed using "6 + 1" ISO injection method. given 15 mg·(kg d) −1 , those low groups 20 50 respectively, control received an equal volume 0.9% NaCl solution. Changes serum troponin (cTnI), creatine isoenzyme (CK-MB), interleukin-1β (IL-1β) levels determined by ELISA. HE staining used observe tissue morphology heart disease. mRNA expression IL-1β NLRP3 RT‒PCR. Mitochondrial damage observed transmission electron microscopy. reactive oxygen species (ROS) detected immunofluorescence. Western blot immunohistochemical detection IL-1β, NLRP3, TAK1, phospho-TAK1 (p-TAK1), p38MAPK, phospho-p38MAPK (p-p38MAPK), nuclear factor-κB (NF-κB),and phospho-NF-κB (p-NF-κB) also performed. Data analysis performed SPSS 25.0 software. In rats, there no obvious arrhythmias ECG, cardiac mitochondria basically normal, level low, myocardial ROS, p-TAK1, p-p38MAPK p-NF-κB weak. Compared with had significant increases scores according ECG ( P < 0.01). Myocardial histopathological injury, weight index (HWI) cTnI CK-MB Additionally, mitochondrial tissue, increased ROS fluorescence intensity, elevated detected( inflammation-related factors 0.01 0.05). decreased three treatment Cardiac significantly improved, HWI injury-related indicators decreased( Damaged p-p38MAPK, decreased. TAK1-p38MAPK-NLRP3 is enhanced arrhythmia. Cinnamaldehyde can regulate signalling, reduce cardiomyocyte pyroptosis, antagonize protect cardiomyocytes inhibiting oxidative stress.

Language: Английский

---