Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: Dec. 2, 2024
Doxorubicin (DOX) drugs used in cancer treatment can cause various adverse effects, including hepatotoxicity. Natural-derived constituents have shown promising effects alleviating chemotherapy-induced toxicities. This study addressed the effect of Avenanthramides-C (AVN-C) rats with DOX-indued
Language: Английский
Theranostics, Journal Year: 2024, Volume and Issue: 15(3), P. 965 - 992
Published: Dec. 2, 2024
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, particularly due to the limited effectiveness current therapeutic options for advanced-stage disease. The efficacy traditional treatments is often compromised by intricate liver microenvironment and inherent heterogeneity. RNA-based therapeutics offer promising alternative, utilizing innovative approach targeting aberrant molecular pathways modulating tumor microenvironment. integration nanotechnology in this field, through development advanced nanocarrier delivery systems, especially lipid nanoparticles (LNPs), polymer (PNPs), bioinspired vectors, enhances precision RNA therapies. This review highlights significant progress nanotherapeutics HCC treatment, covering micro (miRNA), small interfering (siRNA), message (mRNA), activating (saRNA) mediated gene silencing, protein restoration, activation, cancer vaccines, concurrent therapy. It further comprehensively discusses prevailing challenges within landscape provides forward-looking perspective on potential transform treatment.
Language: Английский
Citations
5
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 729, P. 150348 - 150348
Published: July 4, 2024
Language: Английский
Citations
4
Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107698 - 107698
Published: March 1, 2025
Language: Английский
Citations
0
British Journal of Cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 11, 2024
Abstract CTNNB1 , encoding the ß-catenin protein, is a key oncogene contributing to liver carcinogenesis. Hepatocellular carcinoma (HCC) most common form of primary cancer in adult, representing third leading cause cancer-related death. Aberrant activation Wnt/ß-catenin pathway, mainly due mutations gene, observed significant subset HCC. In this review, we first resume major recent advances HCC classification with focus on -mutated subclass. We present regulatory mechanisms involved β-catenin stabilisation, transcriptional activity and binding partner proteins. then describe specific phenotypic characteristics thanks their unique gene expression patterns. constitute full-fledged subclass distinct pathological features such as well-differentiated cells low proliferation rate, association cholestasis, metabolic alterations, immune exclusion invasion. Finally, discuss therapeutic approaches target ß-catenin-mutated tumours innovative perspectives for future drug developments.
Language: Английский
Citations
2
Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2024, Volume and Issue: 3(5), P. 59 - 79
Published: Oct. 22, 2024
Cancer of the cervix is a disease that ubiquitous and frequently severe, it affects women all over world. Conventional treatment methods, which include surgical procedures, chemotherapy, radiation therapy, have been shown to dramatically enhance survival rates; nevertheless, these methods are accompanied with adverse effects difficulties might an influence on quality life patient. In recent years, there has growing interest in utilisation essential oils cancer management cervical cancer. This review offers comprehensive investigation into function various play development It also includes insights possible advantages as well body research conducted them. Additionally, analysis dives future directions issues will be faced this developing industry, particular focus advancements delivery interesting areas. For purpose enhancing anticancer qualities oils, encapsulation solid lipid nanoparticles, nanoemulsification or combining conventional treatments demonstrated promising results. attempts provide viewpoint, balancing potential natural therapies obstacles need addressed. As employment continues develop, study attempt perspective. The strike balance between
Language: Английский
Citations
2
Hepatology, Journal Year: 2023, Volume and Issue: unknown
Published: Sept. 19, 2023
The remarkable impact of RNA nanomedicine during the COVID-19 pandemic has demonstrated expansive therapeutic potential this field in diverse disease contexts. In recent years, targeting liver been paradigm-shifting management metabolic diseases such as hyperoxaluria and amyloidosis. significant diseases, where optimal would benefit from targeted delivery, doses titrated to metabolism, personalized therapy based on specific site interest. review, we discuss in-depth different types nanocarriers used for along with their applications dysfunction-associated steatotic disease, fibrosis, cancers. We further highlight strategies cell-specific delivery future perspectives research emergence small activating RNA, circular base editing approaches.
Language: Английский
Citations
5
Cancer Control, Journal Year: 2024, Volume and Issue: 31
Published: Jan. 1, 2024
Liver cancer, primarily hepatocellular carcinoma, represents a major global health issue with significant clinical, economic, and psychological impacts. Its incidence continues to rise, driven by risk factors such as hepatitis B C infections, nonalcoholic steatohepatitis, various environmental influences. The Wnt/β-Catenin signaling pathway, frequently dysregulated in HCC, emerges promising therapeutic target. Critical genetic alterations, particularly the CTNNB1 gene, involve mutations at key phosphorylation sites on β-catenin’s N-terminal domain (S33, S37, T41, S45) armadillo repeat domains (K335I N387 K). These impede β-catenin degradation, enhancing its oncogenic potential. In addition molecular epigenetic mechanisms, including DNA methylation, histone modifications, noncoding RNAs, further influence tumor progression. However, activation alone is insufficient for hepatocarcinogenesis; additional “hits” are required initiation. Mutations or alterations genes Ras, c-Met, NRF2, LKB1, when combined activation, significantly contribute HCC development Understanding these cooperative provides crucial insights into disease reveals potential strategies. complex interplay between variations microenvironment, coupled novel approaches targeting offers promise improved treatment of HCC. Despite advances, translating preclinical findings clinical practice remains challenge. Future research should focus elucidating how specific pathogenesis, leveraging genetically clengineered mouse models explore distinct impacts, identifying downstream targets. Relevant trials will be essential advancing personalized therapies patient outcomes. This review comprehensive analysis β-Catenin highlighting role diagnosis, targeting, identifies directions improve understanding
Language: Английский
Citations
1
Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: Dec. 2, 2024
Doxorubicin (DOX) drugs used in cancer treatment can cause various adverse effects, including hepatotoxicity. Natural-derived constituents have shown promising effects alleviating chemotherapy-induced toxicities. This study addressed the effect of Avenanthramides-C (AVN-C) rats with DOX-indued
Language: Английский
Citations
0