Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates

Polymers, Journal Year: 2023, Volume and Issue: 15(13), P. 2928 - 2928

Published: July 1, 2023

The limitations associated with the conventional treatment of cancer have necessitated design and development novel drug delivery systems based mainly on nanotechnology. These include various kinds nanoparticles, such as polymeric solid lipid nanostructured carriers, hydrogels, micelles. Among systems, chitosan-based nanoparticles attracted attention researchers to treat cancer. Chitosan is a polycationic polymer generated from chitin characteristics biocompatibility, biodegradability, non-toxicity, mucoadhesiveness, making it an ideal fabricate systems. However, chitosan poorly soluble in water acidic aqueous solutions. Furthermore, owing presence reactive amino groups, can be chemically modified improve its physiochemical properties. derivatives employed which are used most frequently pharmaceutical sector due their possession nanosize, appropriate pharmacokinetic pharmacodynamic properties, non-immunogenicity, improved stability, loading capacity. capable delivering nucleic acids, chemotherapeutic medicines, bioactives using chitosan. derivative-based targeted specific sites via active passive mechanisms. Based many anticancer drugs now better effectiveness, potency, cytotoxicity, or biocompatibility. tailored derivatives, well use therapy, will examined this review.

Language: Английский

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Codelivery of Phytochemicals with Conventional Anticancer Drugs in Form of Nanocarriers

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 889 - 889

Published: March 9, 2023

Anticancer drugs in monotherapy are ineffective to treat various kinds of cancer due the heterogeneous nature cancer. Moreover, available anticancer possessed hurdles, such as drug resistance, insensitivity cells drugs, adverse effects and patient inconveniences. Hence, plant-based phytochemicals could be a better substitute for conventional chemotherapy treatment properties: lesser effects, action via multiple pathways, economical, etc. Various preclinical studies have demonstrated that combination with is more efficacious than individually because plant-derived compounds lower efficacy drugs. suffer from poor aqueous solubility reduced bioavailability, which must resolved Therefore, nanotechnology-based novel carriers employed codelivery These include nanoemulsion, nanosuspension, nanostructured lipid carriers, solid nanoparticles, polymeric micelles, dendrimers, metallic carbon nanotubes provide benefits improved solubility, higher efficacy, dose, dosing frequency, bioavailability compliance. This review summarizes cancer, therapy deliver

Language: Английский

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Plant-derived exosomes: a green approach for cancer drug delivery

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(9), P. 2236 - 2252

Published: Jan. 1, 2024

Plant-derived exosomes (PDEs) show promising potential to be developed as a therapeutic agent against cancer, owing their multiple advantages such low toxicity, biocompatibility, availability, affordability, etc.

Language: Английский

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Carbon nanotube-mediated platinum-based drug delivery for the treatment of cancer: Advancements and future perspectives

European Polymer Journal, Journal Year: 2024, Volume and Issue: 206, P. 112800 - 112800

Published: Jan. 26, 2024

Language: Английский

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ERK pathway agonism for cancer therapy: evidence, insights, and a target discovery framework

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: March 14, 2024

At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp). Inhibitors targeting various effectors within the ERKp have been developed and explored for over two decades. Conversely, a substantial body evidence suggests that both normal cells and, notably to greater extent, cancer exhibit susceptibility hyperactivation ERKp. However, this vulnerability remains relatively unexplored. In review, we reexamine on selective lethality highly elevated in varying backgrounds. We synthesize insights proposed harnessing ERK-associated therapeutical approaches contextualize these established pharmacological cancer-targeting models. Moreover, compile intriguing preclinical findings agonism diverse Lastly, present conceptual framework target discovery regarding agonism, emphasizing utilization mutual exclusivity among oncogenes develop novel targeted therapies precision oncology.

Language: Английский

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Paclitaxel and its semi-synthetic derivatives: comprehensive insights into chemical structure, mechanisms of action, and anticancer properties

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Jan. 30, 2024

Abstract Cancer is a disease that can cause abnormal cell growth and spread throughout the body. It among most significant causes of death worldwide, resulting in approx. 10 million deaths annually. Many synthetic anticancer drugs are available, but they often come with side effects interact negatively other medications. Additionally, many chemotherapy used for cancer treatment develop resistance harm normal cells, leading to dose-limiting effects. As result, finding effective treatments developing new remains challenge. However, plants potent source natural products potential treatment. These biologically active compounds may be basis enhanced or less toxic derivatives. Herbal medicines/phytomedicines, plant-based drugs, becoming more popular treating complicated diseases like due their effectiveness particularly attractive option affordability, availability, lack serious They have broad applicability therapeutic efficacy, which has spurred scientific research into as agents. This review focuses on Paclitaxel (PTX), drug derived from Taxus sp., its ability treat specific tumors. PTX derivatives against various lines. Researchers use this detailed information affordable cancer.

Language: Английский

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Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs

Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100040 - 100040

Published: June 27, 2024

Currently, cancer is the leading cause of death globally. In absence specific treatment and early diagnosis, procedures like surgery, chemotherapy, radiation therapy are often used to manage disease. However, these approaches fail control due inefficacy, nonspecific distribution, side effects drugs. Anticancer drugs essential in reducing cell growth helping damage those cells. severe have limited bioavailability their distribution throughout body. Therefore, development intelligent drug release systems essential. Nanoparticle delivery promising strategies improve therapeutic efficacy safety, overcoming challenges. Among systems, a natural polysaccharide called chitosan, derivative chitin, has gained considerable attention as biocompatible, biodegradable, mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility anticancer drugs, modulation kinetics, biodistribution. Additionally, chitosan can be modified on surface with ligands or stimuli-responsive moieties achieve targeted cells tissues. This review explores recent advances chitosan-based nanoparticle delivery, efficacy, applications therapy.

Language: Английский

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Development of Platinum Complexes for Tumor Chemoimmunotherapy

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(10)

Published: Jan. 3, 2024

Abstract Platinum complexes are potential antitumor drugs in chemotherapy. Their impact on tumor treatment could be greatly strengthened by combining with immunotherapy. Increasing evidences indicate that the activity of platinum is not limited to chemical killing effects, but also extends immunomodulatory actions. This review introduced general concept chemoimmunotherapy and summarized progress as chemoimmunotherapeutic agents recent years. developed into inducers immunogenic cell death, blockers immune checkpoint, regulators signaling pathway, modulators microenvironment, etc. The synergy between chemotherapeutic effects reinforces complexes, helps them circumvent drug resistance systemic toxicity. exploration for may create new opportunities revive discovery metal anticancer drugs.

Language: Английский

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A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

Aggregate, Journal Year: 2024, Volume and Issue: 5(2)

Published: Jan. 4, 2024

Abstract The development of efficient drug delivery systems is essential for improving the efficacy and safety cancer drugs, particularly aggressive difficult‐to‐treat cancers. Covalent organic frameworks (COFs) are emerging as innovative porous nanomaterials in (DDS), due to their unique properties, including metal‐free skeleton, predetermined structures pore geometries, high porosity, large surface area, facile modification potential, good biocompatibility. These characteristics make COFs excellent candidates by enhancing loading capacity enabling precise encapsulation. This review emphasizes importance donor‐acceptor‐based COFs, which provide channels charge transportation, we also explore how π‐conjugated skeleton enhances its long‐acting fluorescent properties facilitates uptake via cell endocytosis. While this primarily focuses on recent advancements COF‐based targeted DDS, it acknowledges challenges posed diverse geometries materials discusses potential solutions. Further, underlines developing future carriers that can successfully specifically target cells, treatment efficiency while reducing adverse side effects.

Language: Английский

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Recent advances in carbon quantum dots for gene delivery: A comprehensive review

Journal of Cellular Physiology, Journal Year: 2024, Volume and Issue: 239(11)

Published: March 7, 2024

Gene therapy is a revolutionary technology in healthcare that provides novel therapeutic options and has immense potential addressing genetic illnesses, malignancies, viral infections. Nevertheless, other obstacles still need to be addressed regarding safety, ethical implications, technological enhancement. Nanotechnology gene fields have shown significant promise transforming medical treatments by improving accuracy, effectiveness, personalization. This review assesses the possible uses of therapy, its obstacles, future research areas, specifically emphasizing creative combination nanotechnology. essential for delivery as it allows development nano-scale carriers, such carbon quantum dots (CQDs), which may effectively transport genes into specific cells. CQDs exhibit distinctive physicochemical characteristics small size, excellent stability, minimal toxicity, render them highly favorable applications. The objective this study describe current advancements utilization delivery. Additionally, intends assess existing research, explore applications, identify opportunities obstacles. offers thorough summary state possibilities using Combining recent findings highlights revolutionize methods.

Language: Английский

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