Langmuir,
Journal Year:
2024,
Volume and Issue:
40(36), P. 19073 - 19085
Published: Aug. 27, 2024
As
nanomaterials
have
gained
prominence
in
drug
delivery
technology,
exploring
their
feasibility
through
computational
methods
is
beneficial
before
practical
tests.
In
this
study,
we
aim
to
evaluate
the
capability
of
porphyrin-based
covalent
organic
framework
COF-366
as
a
nanocarrier
for
two
anticancer
drugs,
irinotecan
(IRI)
and
doxorubicin
(DOX).
The
optimal
binding
conformation
molecules
on
COF
surface
was
predicted
by
using
molecular
docking.
Subsequently,
dynamic
simulation
(MD)
performed
assess
adsorption
mechanism
aqueous
environment.
free
energy
DOX
IRI
estimated
be
-20.07
-23.89
kcal/mol,
respectively.
both
drugs
mainly
influenced
π-π
interaction.
Furthermore,
density
functional
theory
(DFT)
calculation,
natural
bond
orbital
(NBO),
quantum
atoms
(QTAIM)
analyses
were
employed
investigate
structural
stability
Drug@COF
complexes
gain
detailed
understanding
interaction
between
them
at
level.
Based
DFT
results,
it
found
that
addition
interaction,
bis-piperidine-phenylene
affects
surface.
Moreover,
diffusion
behavior
molecule
inside
pore
simulated
ten-layer
COF.
mean
square
displacement
analysis,
coefficients
within
calculated
108
97
um
Biotechnology and Bioengineering,
Journal Year:
2024,
Volume and Issue:
121(7), P. 2017 - 2049
Published: April 25, 2024
Porous
organic
frameworks
(POFs)
represent
a
significant
subclass
of
nanoporous
materials
in
the
field
science,
offering
exceptional
characteristics
for
advanced
applications.
Covalent
(COFs),
as
novel
and
intriguing
type
porous
material,
have
garnered
considerable
attention
due
to
their
unique
design
capabilities,
diverse
nature,
wide-ranging
The
structural
features
COFs,
such
high
surface
area,
tuneable
pore
size,
chemical
stability,
render
them
highly
attractive
various
applications,
including
targeted
controlled
drug
release,
well
improving
sensitivity
selectivity
electrochemical
biosensors.
Therefore,
it
is
crucial
comprehend
methods
employed
creating
COFs
with
specific
properties
that
can
be
effectively
utilized
biomedical
To
address
this
indispensable
fact,
review
paper
commences
concise
summary
different
classifications
synthesizing
COFs.
Second,
highlights
recent
advancements
delivery,
carriers
classification
delivery
systems
biosensing,
encompassing
drugs,
biomacromolecules,
small
biomolecules
detection
biomarkers.
While
exploring
potential
field,
important
acknowledge
limitations
researchers
may
encounter,
which
could
impact
practicality
Third,
concludes
thought-provoking
discussion
thoroughly
addresses
challenges
opportunities
associated
leveraging
This
aims
contribute
scientific
community's
understanding
immense
enhancing
performance
biosensors
Chemistry - An Asian Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Abstract
Covalent
organic
frameworks
(COFs)
are
a
new
type
of
porous
crystalline
material,
which
have
become
an
emerging
platform
for
promoting
the
development
green
energy
technology
due
to
their
high
surface
area,
adjustable
pores,
low
skeleton
density,
and
easy
functionalization.
In
recent
years,
with
continuous
advancement
synthesis
technology,
efficiency
sustainability
COFs
been
significantly
improved,
from
traditional
solvothermal
methods
emergence
various
strategies
such
as
ion
thermal,
mechanochemical,
ultrasound
assisted
methods.
This
article
reviews
main
explores
applications
in
field
energy,
photocatalysis,
gas
adsorption
separation,
electrocatalysis,
battery,
supercapacitor
Proton
exchange
membrane
fuel
cell.
By
analyzing
performance
mechanism
these
detail,
this
further
looks
forward
challenges
future
trends
faced
by
aiming
provide
valuable
reference
inspiration
researchers
related
fields.
