Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment DOI Creative Commons
Franziska Peters,

Windie Höfs,

Hunki Lee

et al.

The Journal of Cell Biology, Journal Year: 2025, Volume and Issue: 224(4)

Published: Jan. 29, 2025

Sphingolipids serve as building blocks of membranes to ensure subcellular compartmentalization and facilitate intercellular communication. How cell type–specific lipid compositions are achieved what is their functional significance in tissue morphogenesis maintenance has remained unclear. Here, we identify a stem cell–specific role for ceramide synthase 4 (CerS4) orchestrating fate decisions skin epidermis. Deletion CerS4 prevents the proper development adult hair follicle bulge (HFSC) compartment due altered differentiation trajectories. Mechanistically, HFSC defects arise from an imbalance key ceramides derivate sphingolipids, resulting hyperactivation noncanonical Wnt signaling. This impaired establishment leads disruption architecture barrier function, ultimately triggering T helper 2–dominated immune infiltration resembling human atopic dermatitis. work uncovers fundamental state–specific sphingolipid profile homeostasis maintaining intact barrier.

Language: Английский

Research progress in Alzheimer's disease and bone-brain axis DOI Creative Commons
Fan Zhang, Wei Zhang

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102341 - 102341

Published: May 15, 2024

Alzheimer's disease (AD) is the most common type of cognitive impairment. AD closely related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms epidemiology pathogenesis. Brain bone tissues can regulate each other different manners through bone-brain axis. This article reviews research progress relationship between axis mechanisms AD, therapy by targeting axis, order deepen understanding communication, promote early diagnosis explore new for patients. Keywords

Language: Английский

Citations

6
RNF43 and ZNRF3 in Wnt Signaling - A Master Regulator at the Membrane DOI Open Access
Fiona Farnhammer, Gabriele Colozza, Jihoon Kim

et al.

International Journal of Stem Cells, Journal Year: 2023, Volume and Issue: 16(4), P. 376 - 384

Published: July 20, 2023

The Wnt β-catenin signaling pathway is a highly conserved mechanism that plays critical role from embryonic development and adult stem cell homeostasis. However, dysregulation of the has been implicated in various diseases, including cancer. Therefore, multiple layers regulatory mechanisms tightly control activation suppression signal. E3 ubiquitin ligases RNF43 ZNRF3, which are known negative regulators pathway, component regulation. These by targeting receptor Frizzled to induce ubiquitination-mediated endo-lysosomal degradation, thus controlling pathway. We also discuss mechanisms, interactors, evolution ZNRF3. This review article summarizes recent findings on ZNRF3 their potential implications for therapeutic strategies target

Language: Английский

Citations

14
Serving up health: How phytochemicals transform food into medicine in the battle against cancer DOI Creative Commons
Eshita Sharma, Manju Tewari,

Priyanka Sati

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: 5(5), P. 1866 - 1908

Published: July 7, 2024

Abstract The escalating global cancer burden underscores the urgent need for more effective therapeutic strategies. Phytochemicals, naturally occurring compounds in plants, have garnered attention their potential chemoprevention and chemotherapy. Their ability to modulate molecular mechanisms influence cell signaling pathways offers a promising avenue management. This review aims synthesize current knowledge on phytochemicals’ chemopreventive chemotherapeutic potential, focusing of action impacts involved cancer. A systematic literature search was conducted across major databases, including PubMed/Medline, Web Science, Scopus, Google Scholar. strategy uses Medical Subject Headings (MeSH) free‐text terms using Boolean operators capture relevant studies. Inclusion criteria targeted original research reviews effects phytochemicals cancer, with specific focus mechanisms. flavonoids, polyphenols, terpenoids, demonstrated significant anticancer properties by inducing cycle arrest, apoptosis, autophagy. They critical pathways, such as cyclooxygenase‐2, nuclear factor kappa B, various growth factor‐related rectify epigenetic alterations, contributing effects. Phytochemicals represent valuable resource developing novel prevention treatment strategies; actions underscore combat. Further is warranted translate these findings into clinical applications, optimizing phytochemical‐based interventions

Language: Английский

Citations

5
Single cell spatial biology over developmental time can decipher pediatric brain pathologies DOI Creative Commons
Ruth Nussinov, Bengi Ruken Yavuz, Hyunbum Jang

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 199, P. 106597 - 106597

Published: July 9, 2024

Pediatric low grade brain tumors and neurodevelopmental disorders share proteins, signaling pathways, networks. They also germline mutations an impaired prenatal differentiation origin. may differ in the timing of events proliferation. We suggest that their pivotal distinct, albeit partially overlapping, outcomes relate to cell states, which depend on spatial location, gene expression during development. These attributes are crucial as develops sequentially, single-cell organization influences state, thus function. Our underlying premise is root cause pediatric differentiation. Data related tumors, disorders, (sub)types, locations, developing scant. However, emerging single technologies, including transcriptomic, biology, high-resolution imaging performed over developmental time, could be transformational deciphering pathologies thereby pharmacology.

Language: Английский

Citations

5
Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care? DOI Creative Commons

Auriane de Pellegars-Malhortie,

Laurence Picque Lasorsa,

Thibault Mazard

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 949 - 949

Published: July 16, 2024

Despite significant progress in cancer prevention, screening, and treatment, the still limited number of therapeutic options is an obstacle towards increasing cure rate. In recent years, many efforts were put forth to develop therapeutics that selectively target different components oncogenic Wnt/β-catenin signaling pathway. These include small molecule inhibitors, antibodies, more recently, gene-based approaches. Although some them showed promising outcomes clinical trials, pathway not targeted routine practice for management. As most anticancer treatments, a critical limitation use inhibitors their index, i.e., difficulty combining effective activity with acceptable toxicity. Protecting healthy tissues from effects major issue due vital role adult tissue homeostasis regeneration. this review, we provide up-to-date summary trials on examine anti-tumor associated adverse events, explore strategies under development improve benefit/risk profile approach.

Language: Английский

Citations

5
Unlocking Hope: Therapeutic Advances and Approaches in Modulating the Wnt Pathway for Neurodegenerative Diseases DOI Creative Commons

Navid Faraji,

Negar Ebadpour, Mohammad Abavisani

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Language: Английский

Citations

5
Vitamin D and cancer DOI

Ranjana P. Bird

Advances in food and nutrition research, Journal Year: 2024, Volume and Issue: unknown, P. 92 - 159

Published: Jan. 1, 2024

Language: Английский

Citations

4
Role of Wnt/β-catenin pathway in cancer drug resistance: Insights into molecular aspects of major solid tumors DOI
Charudatt Samant, Ramesh R. Kale, K. Sreedhara Ranganath Pai

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 729, P. 150348 - 150348

Published: July 4, 2024

Language: Английский

Citations

4
Harnessing the role of aberrant cell signaling pathways in glioblastoma multiforme: a prospect towards the targeted therapy DOI
S. M. Murshid Hasan, Zimam Mahmud,

Mahmud Hossain

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Oct. 19, 2024

Language: Английский

Citations

4
Biological Characterization of One Oxadiazole Derivative (5(4‐Hydroxyphenyl)‐2‐(N‐Phenyl Amino)‐1,3,4‐Oxadiazole): In Vitro, In Silico, and Network Pharmacological Approaches DOI Open Access
Tuğçe Duran,

Irem Balikci,

Busra Buyukkosucu

et al.

Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(1)

Published: Jan. 1, 2025

ABSTRACT Oxadiazole compounds are of great interest because they have a range biological activities ranging from antioxidants to anticancer agents. Against this background, we wanted demonstrate the antioxidant, enzyme inhibitory, and effects 5(4‐hydroxyphenyl)‐2‐(N‐phenylamino)‐1,3,4‐oxadiazole (Hppo). Antioxidant abilities were measured through free radical scavenging reducing power tests. Enzyme inhibitory studied by cholinesterases, tyrosinase, amylase, glucosidase. The effect was tested on pancreatic cancer cell lines (PANC‐1, CRL‐169) HEK293 lines. compound showed significant antioxidant activity (particularly in CUPRAC (cupric acid‐reducing capacity) assay) properties glucosidase inhibition). In test, strong with apoptotic signaling pathways. These results confirmed molecular modeling bioinformatics tools. Thus, our findings can provide novel versatile for development multidirectional drugs pharmaceutical industry.

Language: Английский

Citations

0