Yangyin Yiqi Huoxue Decoction improves the mechanism of microglia activation against CIS-induced neuroinflammatory injury by regulating the Wnt signaling pathway

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156387 - 156387

Published: Jan. 12, 2025

Language: Английский

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Investigating the Expression Pattern, Prognostic and Immunological Significance of the WNT family in Breast Cancer

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Breast cancer (BRCA) is one of the most diagnosed cancers and leading cause cancer-related deaths among women globally. Previous studies have shown that WNT (wingless type) family plays a role in development various cancers. However, comprehensive analysis WNTs BRCA remains largely unexplored. In this extensive study, we examined expression patterns, clinical relevance, survival outcomes associated with identified key prognostic WNTs. We further investigated genetic alterations, DNA methylation, drug sensitivity using cBioPortal, SMART, GSCA databases. Data from GEO DepMap were used for validation. Our findings revealed WNT2 WNT7B significantly upregulated, while WNT11 was downregulated, which affected overall patients BRCA. Amplification common type alteration selected analysis, showing significant correlation immune cells therapy-related genes. Enrichment involvement crucial pathways responsible cancer. Additionally, their co-expressed genes strongly efficacy anticancer drugs. This study highlights dysregulation progression patient survival, suggesting potential immunotherapeutic target valuable biomarker management treatment.

Language: Английский

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Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer’s disease mouse model

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 12, 2025

Characteristic cerebral pathological changes of Alzheimer's disease (AD) such as glucose hypometabolism or the accumulation cleavage products amyloid precursor protein (APP), known Aβ peptides, lead to sustained endoplasmic reticulum (ER) stress and neurodegeneration. To preserve ER homeostasis, cells activate their unfolded response (UPR). The rhomboid-like-protease 4 (RHBDL4) is an enzyme that participates in UPR by targeting proteins for proteasomal degradation. We demonstrated previously RHBDL4 cleaves APP HEK293T cells, leading decreased total Aβ. More recently, we showed processes mouse primary mixed cortical cultures well. Here, aim examine physiological relevance brain. first found brain samples from AD patients model (APPtg) increased mRNA expression. determine effects RHBDL4's absence on physiology vivo, crossed APPtg mice a knockout (R4-/-) model. deficiency led amyloidogenic processing when compared controls. Contrary expectations, assessed cognitive tests, rescued cognition 5-month-old female mice. Informed unbiased RNA-seq data, vitro vivo leads greater levels active β-catenin due clearance. Decreased activity underlie defects AD. Our work suggests expression AD, addition regulating levels, aberrant degradation β-catenin, contributing impairment.

Language: Английский

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Autologous Versus Allogeneic Adipose-Derived Mesenchymal Stem Cell Therapy for Knee Osteoarthritis: A Systematic Review, Pairwise and Network Meta-Analysis of Randomized Controlled Trials

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

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From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4271 - 4271

Published: April 30, 2025

The brain-derived neurotrophic factor (BDNF) has become one of the cornerstones neuropathology, influencing synaptic plasticity, cognitive resilience, and neuronal survival. Apart from its molecular biology, BDNF is a powerful target for transformative benefit in precision medicine, leading to innovative therapeutic approaches neurodegenerative psychiatric diseases like Alzheimer's disease (AD), Parkinson's (PD), major depressive disorder (MDD), post-traumatic stress (PTSD). Nevertheless, clinical applicability obstructed by hurdles delivery, patient-specific diversity, pleiotropic signaling. Here, we summarize findings research, including regulatory pathways diagnostic/prognostic biomarkers integrative approaches. We describe delivery systems, such as lipid nanoparticle-based mRNA therapies CRISPR-dCas9-based epigenetic editing that bypass obstacles BBB (blood-brain barrier) enzymatic degradation. recent implementation multiplex panels combining biodynamic indicators with tau amyloid-β signaling markers showcases novel levels specificity both early detection potential monitoring. Humanized preclinical models iPSC-derived neurons organoids point key role neurodeveloping processes, paralleling advances bridging observation environments. Moreover, tools delivering TrkB activators or AI-based dynamic care platforms enable tailored scalable treatments. This review also aims extend framework used understanding BDNF's relevance traditional situating more work detailing actions ischemic tissues gut-brain axis context systemic health. Finally, outline roadmap incorporation BDNF-centered into worldwide healthcare, highlighting ethical issues, equity, interdisciplinary decomposition. heralds new era neuroscience revolutionizing brain health paving way advancement medicine.

Language: Английский

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Axonal transcriptome reveals upregulation of PLK1 as a protective mechanism in response to increased DNA damage in FUSP525L spinal motor neurons

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Mutations in the gene

Language: Английский

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