Stem Cells International,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Long
noncoding
RNAs
(lncRNAs),
as
a
potentially
new
and
crucial
element
of
biological
regulation,
have
gained
widespread
attention
in
recent
years.
Our
previous
work
identified
lncRNA
empty
spiracles
homeobox
2
antisence
(EMX2‐AS)
was
significantly
increased
during
the
osteoblast
differentiation
mesenchymal
stem
cells
(MSCs).
Overexpression
EMX2‐AS
promoted
osteogenesis
vitro
enhanced
heterotopic
bone
formation
vivo,
whereas
knockdown
had
opposite
effect.
EMX2
could
negatively
regulate
MSCs.
80%
expressed
cytoplasm
Mechanistic
analysis
revealed
that
acts
positive
regulator
osteogenic
through
interaction
with
suppression
its
expression
at
translational
level
Wnt/
β
‐catenin
pathway
is
involved
EMX2‐AS/EMX2
regulated
differentiation.
findings
not
only
provide
targets
for
treatment
diseases
related
to
disruption
but
also
enrich
understanding
regulation
mechanisms
cell
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 26, 2023
Lactate,
traditionally
regarded
as
a
metabolic
waste
product
at
the
terminal
of
glycolysis
process,
has
recently
been
found
to
have
multifaceted
functional
roles
in
metabolism
and
beyond.
A
reprogramming
phenomenon
commonly
seen
tumor
cells,
known
"Warburg
effect,"
sees
high
levels
aerobic
result
an
excessive
production
lactate.
This
lactate
serves
substrate
that
sustains
not
only
survival
cancer
cells
but
also
immune
cells.
However,
it
inhibits
function
tumor-associated
macrophages
(TAMs),
group
innate
ubiquitously
present
solid
tumors,
thereby
facilitating
evasion
malignant
Characterized
by
their
plasticity,
TAMs
are
generally
divided
into
pro-inflammatory
M1
phenotype
pro-tumour
M2
phenotype.
Through
process
'education'
lactate,
tend
adopt
immunosuppressive
collaborate
with
promote
angiogenesis.
Additionally,
there
is
growing
evidence
linking
epigenetic
modifications,
suggesting
participation
histone
modification
diverse
cellular
events
within
microenvironment
(TME).
In
this
review,
we
delve
recent
discoveries
concerning
particular
focus
on
impact
TAMs.
We
aim
consolidate
molecular
mechanisms
underlying
lactate-induced
TAM
polarization
angiogenesis
explore
lactate-mediated
crosstalk
between
Finally,
touch
upon
latest
progress
immunometabolic
therapies
drug
delivery
strategies
targeting
production,
offering
new
perspectives
for
future
therapeutic
approaches.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 8, 2024
Rhodiola
rosea
is
a
valuable
functional
medicinal
plant
widely
utilized
in
China
and
other
Asian
countries
for
its
anti-fatigue,
anti-aging,
altitude
sickness
prevention
properties.
Salidroside,
most
active
constituent
derived
from
,
exhibits
potent
antioxidative,
hypoxia-resistant,
anti-inflammatory,
anticancer,
anti-aging
effects
that
have
garnered
significant
attention.
The
appreciation
of
the
pharmacological
role
salidroside
has
burgeoned
over
last
decade,
making
it
beneficial
option
treatment
multiple
diseases,
including
atherosclerosis,
Alzheimer’s
disease,
Parkinson’s
cardiovascular
more.
With
renoprotective
effects,
parallel
with
inhibition
oxidative
stress
inflammation,
holds
promise
as
potential
therapeutic
agent
kidney
damage.
This
article
provides
an
overview
microinflammatory
state
disease
discuss
current
strategies,
particular
focus
on
highlighting
recent
advancements
utilizing
renal
disease.
mechanisms
action
are
primarily
associated
regulation
gene
protein
expression
glomerular
endothelial
cells,
podocytes,
tubule
mesangial
cells
cell
carcinoma
cell,
TNF-α,
TGF-β,
IL-1β,
IL-17A,
IL-6,
MCP-1,
Bcl-2,
VEGF,
ECM
protein,
caspase-3,
HIF-1α,
BIM,
well
modulation
AMPK/SIRT1,
Nrf2/HO-1,
Sirt1/PGC-1α,
ROS/Src/Cav-1,
Akt/GSK-3β,
TXNIP-NLRP3,
ERK1/2,
TGF-β1/Smad2/3,
PI3K/Akt,
Wnt1/Wnt3a
β-catenin,
TLR4/NF-κB,
MAPK,
JAK2/STAT3,
SIRT1/Nrf2
pathways.
To
best
our
knowledge,
this
review
first
to
comprehensively
cover
protective
diverse
suggests
great
be
developed
drug
metabolic
syndrome,
cerebrovascular
diseases
complications.
Cell Biology International,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Breast
cancer
is
a
multifaceted
and
prevalent
malignancy,
impacting
considerable
proportion
of
women
globally.
Numerous
signaling
pathways
intricately
regulate
cellular
functions
such
as
growth,
proliferation,
survival.
Among
the
various
regulators,
lncRNAs
have
emerged
significant
players
despite
their
inability
to
encode
proteins.
An
expanding
body
literature
underscores
pivotal
roles
play
in
biology,
particularly
context
breast
cancer.
Autophagy,
process
dedicated
degradation
recycling
components,
now
recognized
crucial
factor
initiation
progression.
The
interplay
between
lncRNAs,
pathways,
autophagy
pathophysiology
remains
an
active
area
investigation.
Researchers
identified
specific
that
are
dysregulated
patients,
influencing
modulation
key
pathways.
Using
experimental
methodologies
bioinformatics
approaches,
multiple
been
elucidated,
providing
deeper
insights
into
contributions
pathogenesis
metastatic
processes.
In
summary,
pathophysiological
landscape
characterized
by
complex
interactions
involving
lncRNA-mediated
autophagy.
This
understanding
paves
way
for
identifying
novel
therapeutic
targets,
prognostic
markers,
diagnostic
ultimately
contributing
improved
treatment
outcomes
management.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
165, P. 115090 - 115090
Published: June 28, 2023
Tumor-associated
macrophages
(TAMs)
are
key
components
of
tumor
immune
microenvironment
and
play
a
dual
role
in
promoting
growth
anti-tumor
immunity.
Therefore,
regulating
TAMs
has
become
promising
method
cancer
immunotherapy.
NF-
κB
pathway
is
the
regulatory
TAMs.
Targeting
this
shown
potential
to
improve
microenvironment.
At
present,
there
still
some
controversies
idea
combined
therapy
field.
This
article
reviews
progress
field
immunotherapy
improving
by
exploring
mechanism
(including
M1
polarization,
inhibiting
M2
polarization
infiltration).
Non-coding RNA Research,
Journal Year:
2024,
Volume and Issue:
9(3), P. 667 - 677
Published: March 14, 2024
Lung
cancer
(LC)
is
considered
to
have
the
highest
mortality
rate
around
world.
Because
there
are
no
early
diagnostic
signs
or
efficient
clinical
alternatives,
distal
metastasis
and
increasing
numbers
of
recurrences
a
challenge
in
management
LC.
Long
non-coding
RNAs
(lncRNAs)
recently
been
recognized
as
critical
regulator
involved
progression
treatment
response
The
Wnt/β-catenin
pathway
has
shown
influence
LC
occurrence
progress.
Therefore,
discovering
connections
between
Wnt
signaling
lncRNAs
may
offer
new
therapeutic
targets
for
improving
management.
In
this
review,
purpose
article
present
possible
approaches
by
reviewing
particular
relationships,
key
processes,
molecules
associated
beginning
development
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(13), P. 6798 - 6824
Published: Jan. 1, 2024
In
recent
decades,
natural
compounds
derived
from
herbal
medicine
or
dietary
sources
have
played
important
roles
in
prevention
and
treatment
of
various
diseases
attracted
more
attention.
Curcumin,
extracted
the
