Scutellaria baicalensis and its flavonoids in the treatment of digestive system tumors DOI Creative Commons
Kangning Zhao, Jinlong Zhang, Lin Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Scutellaria baicalensis has been used for the treatment of digestive system disorders thousands years in China and other regions. Modern research have revealed its therapeutic efforts tumors. Thus, to review updated progress S. main flavonoids tumors past 10 years, this article summarized effect molecular mechanisms 5 on oral cavity, esophagus, stomach, colon, liver, pancreas by inhibiting tumor cell proliferation, inducing autophagy, stimulating immune response, increasing drug sensitivity. In conclusion, could be applied treat with different type methods.

Language: Английский

Nitroaromatic-Based Triazene Prodrugs to Target the Hypoxic Microenvironment in Glioblastoma DOI
Cláudia Braga, Margarida Silva, M. Luísa Corvo

et al.

RSC Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 16(3), P. 1350 - 1362

Published: Jan. 1, 2025

Nitroaromatic-based triazene prodrugs elicited enhanced cytotoxicity and apoptosis in hypoxic LN-229 glioblastoma cells comparing to temozolomide, highlighting their therapeutic potential for multiforme.

Language: Английский

Citations

0
The Mechanism of Acupuncture Regulating Autophagy: Progress and Prospect DOI Creative Commons

Jing He,

Min He, Mengmeng Sun

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 263 - 263

Published: Feb. 11, 2025

Autophagy plays a crucial role in the physiopathological mechanisms of diseases by regulating cellular functions and maintaining homeostasis, which has garnered extensive attention from researchers worldwide. The holistic regulation bidirectional effects acupuncture can modulate autophagy, promoting or restoring homeostasis body's internal environment to achieve therapeutic outcomes. This paper systematically reviews research progress on use for treating various via autophagy pathway, summarizes signal pathways related analyzes deficiencies present existing research. review results indicate that mechanism action dysfunction is reflected changes LC3, Beclin1, p53, autophagy-associated (ATG) protein expression, regulates signaling key proteins genes. regulatory effect capacity bidirectional: it inhibits abnormal activation prevent exacerbation injury reduce apoptosis, while also activating enhancing promote elimination inflammation oxidative stress. Further analysis suggests are insufficiently explored. Future should prioritize development more appropriate animal models, analyzing accuracy relevant specificity indicators, exploring synergistic among targets pathways, clarifying at stages evaluating efficacy modulating. offers valuable insights into acupuncture.

Language: Английский

Citations

0
Emerging Role of Hypoxia-Inducible Factors (HIFs) in Modulating Autophagy: Perspectives on Cancer Therapy DOI Open Access
Maroua Jalouli

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1752 - 1752

Published: Feb. 19, 2025

Hypoxia-inducible factors (HIFs) are master regulators of cellular responses to low oxygen levels and modulate autophagy, a conserved process essential for maintaining homeostasis. Under hypoxic conditions, HIFs regulate the expression autophagy-related genes influence autophagic flux stress responses. Dysregulated hypoxia-induced autophagy promotes cancer cell survival, metabolism, metastasis, thereby contributing treatment resistance. Targeting HIF-mediated pathways or modulating processes offers potential improve traditional therapies overcome drug Pharmacological inhibitors either alone in combination with other treatments, may disrupt pro-survival mechanisms within tumor microenvironment. Further research is needed elucidate intricate interplay between HIF signaling machinery cells. Understanding these could pave way novel therapeutic strategies enhance outcomes combat This review highlights complex relationship development therapy, offering insights into how targeting patient outcomes.

Language: Английский

Citations

0
LncRNA HITT inhibits autophagy by attenuating ATG12-ATG5-ATG16L1 complex formation DOI
Hao Liu, Xingwen Wang,

B. Li

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217532 - 217532

Published: Feb. 1, 2025

Language: Английский

Citations

0
H3K36me2 methyltransferase NSD2/WHSC1 promotes triple-negative breast cancer metastasis via activation of ULK1-dependent autophagy DOI Creative Commons
Danyang Chen, Xiaohui Chen,

Mingqiang Yang

et al.

Autophagy, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Metastasis is the primary cause for treatment failure and poor prognosis in patients with triple-negative breast cancer (TNBC). Macroautophagy/autophagy plays a crucial role tumor growth metastasis. Genetic or epigenetic regulation of autophagy-related factors alters autophagy levels, which subsequently promotes progression affects therapeutic effectiveness. However, molecular basis transcriptional TNBC poorly understood. In this study, we reveal histone methyltransferase NSD2/WHSC1 (nuclear receptor binding SET domain protein 2) as novel regulator progression. We demonstrate that expression NSD2 significantly upregulated cells high correlated survival. Elevated metastasis multiple models. Mechanistically, ULK1 (unc-51 like activating kinase 1) identified target NSD2-mediated H3K36me2 methylation directly activates transcription cells. Notably, NSD2-induced facilitates autophagosome maturation increases autophagic flux, thus promoting malignancy TNBC. Furthermore, pharmacological inhibition using MS159 MCTP-39 suppresses autophagy, growth, both vivo vitro. conclusion, our findings pivotal NSD2-H3K36me2 axis regulating identify NSD2-ULK1-autophagy signaling promotion progression, suggesting may be an effective strategy

Language: Английский

Citations

0
The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism DOI Creative Commons
Yikai Zhang, Yi Xie, Shenglong Xia

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Colorectal cancer (CRC) is a leading cause of mortality while diabetes recognized risk factor for CRC. Here we report that tirzepatide (TZP), novel polypeptide/glucagon-like peptide 1 receptor (GIPR/GLP-1R) agonist the treatment diabetes, has role in attenuating CRC growth. TZP significantly inhibited colon cell proliferation promoted apoptosis vitro and induced durable tumor regression vivo under hyperglycemic nonhyperglycemic conditions across multiple murine models. As glucose metabolism known to critically regulate progression, spatial metabolomics results revealed metabolites are robustly reduced regions TZP-treated mice. uptake destabilized hypoxia-inducible factor-1 alpha (HIF-1α) with expression activity rate-limiting enzymes 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) phosphofructokinase (PFK-1). These effects contributed downregulation glycolysis tricarboxylic acid (TCA) cycle. also delayed development patient-derived xenograft (PDX) mouse model accompanied by HIF-1α mediated PFKFB3-PFK-1 inhibition. Therefore, study provides strong evidence glycolysis-blocking TZP, besides its application treating type 2 potential preclinical studies as therapy colorectal used either monotherapy or combination other anticancer therapies.

Language: Английский

Citations

0
Alterations in genes involved in glycolysis and hypoxia affect the prognosis of pancreatic cancer DOI Creative Commons
Jiayue Zou,

Qilu Zhu,

Yizhang Sun

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34104 - e34104

Published: July 1, 2024

To construct a prognostic model for pancreatic cancer based on glycolytic and hypoxic metabolic subtypes. analyze the biological characteristics of these subtypes explore potential therapeutic options.

Language: Английский

Citations

1
Scutellaria baicalensis and its flavonoids in the treatment of digestive system tumors DOI Creative Commons
Kangning Zhao, Jinlong Zhang, Lin Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Scutellaria baicalensis has been used for the treatment of digestive system disorders thousands years in China and other regions. Modern research have revealed its therapeutic efforts tumors. Thus, to review updated progress S. main flavonoids tumors past 10 years, this article summarized effect molecular mechanisms 5 on oral cavity, esophagus, stomach, colon, liver, pancreas by inhibiting tumor cell proliferation, inducing autophagy, stimulating immune response, increasing drug sensitivity. In conclusion, could be applied treat with different type methods.

Language: Английский

Citations

0