Molecules,
Journal Year:
2023,
Volume and Issue:
28(17), P. 6370 - 6370
Published: Aug. 31, 2023
Herbal
medicines
have
gained
recognition
among
physicians
and
patients
due
to
their
lower
adverse
effects
compared
modern
medicines.
They
are
extensively
used
treat
various
diseases,
including
cancer,
cardiovascular
issues,
chronic
inflammation,
microbial
contamination,
diabetes,
obesity,
hepatic
disorders,
others.
Unfortunately,
the
clinical
application
of
herbal
is
limited
by
low
solubility
inadequate
bioavailability.
Utilizing
in
form
nanocrystals
(herbal
medicine
nanocrystals)
has
shown
potential
enhancing
bioavailability
reducing
particle
size,
increasing
specific
surface
area,
modifying
absorption
mechanisms.
Multiple
studies
demonstrated
that
these
significantly
improve
drug
efficacy
toxicity
This
review
comprehensively
examines
therapeutic
approaches
based
on
nanocrystals.
It
covers
preparation
principles,
key
factors
influencing
nucleation
polymorphism
control,
applications,
limitations.
The
underscores
importance
optimizing
delivery
systems
for
successful
nanocrystal
therapeutics.
Furthermore,
it
discusses
main
challenges
opportunities
developing
purpose
treating
conditions
such
as
inflammatory
mental
nervous
antimicrobial
infections.
In
conclusion,
we
deliberated
regarding
hurdles
forthcoming
outlook
realm
nanotoxicity,
vivo
kinetics,
ingredients
stabilizers
nanocrystals,
surmounting
resistance
through
utilization
nanocrystalline
formulations
medicine.
We
anticipate
this
will
offer
innovative
insights
into
development
a
promising
novel
strategy.
Psychopharmacology,
Journal Year:
2021,
Volume and Issue:
238(11), P. 3025 - 3053
Published: Oct. 13, 2021
Abstract
Rationale
Chemotherapy-induced
cognitive
impairment
(CICI),
chemobrain,
and
chemofog
are
the
common
terms
for
mental
dysfunction
in
a
cancer
patient/survivor
under
influence
of
chemotherapeutics.
CICI
is
manifested
as
short/long
term
memory
problems
delayed
processing,
which
interferes
with
person’s
day-to-day
activities.
Understanding
mechanisms
help
developing
therapeutic
interventions
that
may
alleviate
disease
condition.
Animal
models
facilitate
critical
evaluation
to
elucidate
underlying
form
an
integral
part
verifying
different
treatment
hypotheses
strategies.
Objectives
A
methodical
scientific
literature
required
understand
changes
associated
use
chemotherapeutic
agents
preclinical
studies.
This
review
mainly
emphasizes
animal
developed
various
individually
combination,
their
proposed
contributing
dysfunction.
also
points
toward
analysis
chemobrain
healthy
animals
mechanism
absence
tumor
tumor-bearing
mimic
human
conditions
screen
potential
drug
candidates
against
chemobrain.
Results
Substantial
deficit
result
commonly
used
was
evidenced
animals.
Spatial
episodic
impairments,
alterations
neurotrophins,
oxidative
inflammatory
markers,
long-term
potentiation
were
observed
irrespective
agent.
Conclusion
Dyscognition
exists
one
serious
side
effects
chemotherapy.
Due
differing
tendencies
alter
behavioral
biochemical
parameters,
chemotherapy
present
significant
risk
resulting
impairments
well
Molecules,
Journal Year:
2023,
Volume and Issue:
28(17), P. 6370 - 6370
Published: Aug. 31, 2023
Herbal
medicines
have
gained
recognition
among
physicians
and
patients
due
to
their
lower
adverse
effects
compared
modern
medicines.
They
are
extensively
used
treat
various
diseases,
including
cancer,
cardiovascular
issues,
chronic
inflammation,
microbial
contamination,
diabetes,
obesity,
hepatic
disorders,
others.
Unfortunately,
the
clinical
application
of
herbal
is
limited
by
low
solubility
inadequate
bioavailability.
Utilizing
in
form
nanocrystals
(herbal
medicine
nanocrystals)
has
shown
potential
enhancing
bioavailability
reducing
particle
size,
increasing
specific
surface
area,
modifying
absorption
mechanisms.
Multiple
studies
demonstrated
that
these
significantly
improve
drug
efficacy
toxicity
This
review
comprehensively
examines
therapeutic
approaches
based
on
nanocrystals.
It
covers
preparation
principles,
key
factors
influencing
nucleation
polymorphism
control,
applications,
limitations.
The
underscores
importance
optimizing
delivery
systems
for
successful
nanocrystal
therapeutics.
Furthermore,
it
discusses
main
challenges
opportunities
developing
purpose
treating
conditions
such
as
inflammatory
mental
nervous
antimicrobial
infections.
In
conclusion,
we
deliberated
regarding
hurdles
forthcoming
outlook
realm
nanotoxicity,
vivo
kinetics,
ingredients
stabilizers
nanocrystals,
surmounting
resistance
through
utilization
nanocrystalline
formulations
medicine.
We
anticipate
this
will
offer
innovative
insights
into
development
a
promising
novel
strategy.
